Results 81 to 90 of about 7,845 (264)

RESTORATION OF MOTOR AND NON-MOTOR FUNCTIONS BY NEUROTROPHIC FACTORS IN NONHUMAN PRIMATES WITH DOPAMINE DEPLETION [PDF]

open access: yes, 2013
Parkinson’s disease (PD) is a progressive debilitating neurodegenerative disorder characterized by resting tremor, rigidity, bradykinesia and postural instability. As the disease progresses there is a loss of dopamine (DA) neurons in the substantia nigra
Subramanian, Krishna
core  

Lipid‐based Nano‐delivery systems as a promising strategy for the treatment of epilepsy: Current status and challenges

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Epilepsy is a prevalent chronic neurological disorder characterized by abnormal neuronal electrical activity. The primary treatment modality for individuals with epilepsy (PWE) is antiseizure medication (ASM). The multiple potential factors contributing to treatment resistance in epilepsy may be attributed to the inability of ASMs to
Priya Kannan Varshini   +9 more
wiley   +1 more source

Unveiling sleep disturbances in KCNB1‐related disorders: Insights from a cohort of 78 individuals

open access: yesEpilepsia Open, EarlyView.
Abstract Objectives Sleep disturbances are frequent comorbidities in epilepsies and developmental encephalopathies. This study aimed to characterize sleep abnormalities in individuals with KCNB1‐related disorders, focusing on their prevalence, clinical manifestations, and impact on daily functioning.
Giovanna Scorrano   +4 more
wiley   +1 more source

Perampanel as add‐on in high‐grade glioma–related epilepsy: Seizure control and QoL in a prospective, multicenter, real‐world 6‐month follow‐up study

open access: yesEpilepsia Open, EarlyView.
Abstract Objective High‐grade astrocytomas, including glioblastomas, are aggressive brain tumors with poor prognosis and a 5‐year survival below 7%. Seizures affect up to 75% of glioma patients, especially in low‐grade tumors but also in high‐grade cases.
Matteo Impellizzeri   +7 more
wiley   +1 more source

Psychometric properties of the Epworth Sleepiness Scale in Brazilian medical students

open access: yesArquivos de Neuro-Psiquiatria
Background Excessive daytime sleepiness (EDS) refers to the propensity to become drowsy or fall asleep when the intention and expectation would be to stay awake, and the Epworth Sleepiness Scale (ESS) is an easy-to-apply instrument that can be
Renato Canevari Dutra da Silva   +4 more
doaj   +1 more source

El sistema hipocretina / orexina en la fisiopatología de las hipersomnias de origen central [PDF]

open access: yes, 2007
[spa] INTRODUCCIÓN. El sistema hipocretina/orexina es un sistema neurotransmisor hipotalámico con funciones promotoras de la vigilia. La narcolepsia, enfermedad caracterizada por una excesiva somnolencia diurna y manifestaciones anormales del sueño REM ...
Martínez Rodríguez, José Enrique
core  

Effects of sleep disorders on dementia : an epidemiological approach

open access: yes, 2022
De plus en plus d’études suggèrent que les troubles du sommeil sont associés à un risque augmenté de démence. Cependant, les résultats sont très hétérogènes et des lacunes persistent sur les mécanismes impliqués dans cette association ainsi que sur l ...
Cavailles, Clémence
core  

Fragmentary Hypnic Myoclonus and Other Isolated Motor Phenomena of Sleep

open access: yes, 2021
Excessive fragmentary hypnic myoclonus, hypnic jerks, hypnagogic foot tremor, alternating leg muscle activation, and sleep-related cramps are less known sleep-related motor disorders (SRMDs).
Provini F., Baldelli L.
core   +1 more source

Sleep Health in Bulimia Nervosa: A Systematic Review

open access: yesEuropean Eating Disorders Review, EarlyView.
ABSTRACT Objective Research on sleep in bulimia nervosa (BN) is methodologically varied and yields inconsistent findings. This review synthesised BN‐sleep studies and examined whether comorbid mood disorders contribute to sleep disturbance. Method PsycINFO, Medline (Ovid), and Scopus were searched for English or French quantitative studies comparing ...
Samantha Kenny   +4 more
wiley   +1 more source

Sleep Complaints, Sleep and Breathing Disorders in Myotonic Dystrophy Type 2 [PDF]

open access: yes, 2019
PURPOSE OF REVIEW: To update the current knowledge concerning sleep complaints and breathing disorders in myotonic dystrophy type 2 (DM2) and to better understand if sleep and breathing symptoms may add a further clinical definition of DM2.
Maestri, M   +26 more
core   +1 more source

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