Results 61 to 70 of about 1,112,463 (306)

Sex assignment in conditions affecting sex development [PDF]

open access: yes, 2017
The newborn infant with atypical genitalia presents a challenging clinical scenario and requires expert input. There have been appreciable advances in our knowledge of the underlying causes that may lead to a mere difference or a more serious disorder of
Ahmed, S. Faisal, Markosyan, Renata
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Big boys don't cry: Depression and men [PDF]

open access: yes, 2008
Men are a numerical minority group receiving a diagnosis of, and treatment for, depression. However, community surveys of men and of their mental health issues (e.g. suicide and alcoholism) have led some to suggest that many more men have depression than
Branney, P, White, A
core   +1 more source

Mental, behavioral and neurodevelopmental disorders in the ICD-11 : An international perspective on key changes and controversies [PDF]

open access: yes, 2020
The Author(s). 2020Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, andreproduction in any ...
Berk, Michael   +16 more
core   +9 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Complete Androgen Insensitivity Syndrome: A Problem-Based Learning Case

open access: yesMedEdPORTAL, 2016
Introduction To address the lack of medical education on lesbian, gay, bisexual, transgender, queer (LGBTQ), and difference in sex development–affected (DSD-affected) individuals, the University of Louisville initiated the eQuality project.
Adam Neff, Suzanne Kingery
doaj   +1 more source

Mutation of c.244G>T in NR5A1 gene causing 46, XY DSD by affecting RNA splicing

open access: yesOrphanet Journal of Rare Diseases, 2021
Objective To identify the pathogenic mechanism of the c.244G>T mutation in NR5A1 gene found in a Chinese patient with 46, XY disorders of sex development (DSD). Subjects and methods: Genomic DNA was extracted from a Chinese 46, XY DSD patient.
Bingqing Yu   +5 more
doaj   +1 more source

An approach to the management and care of an individual with 46, XX ovotesticular disorder of sexual differentiation

open access: yesPhilippine Journal of Obstetrics and Gynecology, 2023
Ovotesticular disorder of sexual differentiation (OT-DSD) is a rare condition defined by the presence of both testicular and ovarian elements in the same individual.
Maria Angela B. de Castro-Abesamis   +1 more
doaj   +1 more source

Malignant Germ Cell Tumors and Disorders of Sex Development [PDF]

open access: yes, 2015
__Abstract__ The thesis focuses on selected disorders of sex development (DSD) with an increased risk of gonadal germ cell cancer (GCC) and aims to contribute to the refinement of management of the DSD at risk.
Kaprová-Pleskačová, J. (Jana)
core  

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

open access: yesFEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić   +3 more
wiley   +1 more source

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