Results 61 to 70 of about 25,630 (289)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Disperse dyes based on 2-methyl-3-[3’-amino-phthalimido]-4(3H)-quinazilinone [PDF]

Journal of the Serbian Chemical Society, 2002
A series of new heterocyclic disperse dyes has been prepared by subsequent diazotization of 2-methyl-3-[3’-aminophthalimido]-4(3H)-quinazolinone and coupling with various mono- and di-N-substituted derivatives of aniline.
Patel Vijay H., Patel Manish.P., Patel Ranjan G.   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

An Alternative Use of Olive Pomace as a Wide-Ranging Bioremediation Strategy to Adsorb and Recover Disperse Orange and Disperse Red Industrial Dyes from Wastewater

Separations, 2017
In this paper, industrial dyes, Disperse Red and Disperse Orange, were studied as model pollutants to show the excellent performance of olive pomace (OP) in sequestering and recovering these dangerous dyes from wastewater.
Vito Rizzi, Francesco D’Agostino, Jennifer Gubitosa, Paola Fini, Andrea Petrella, Angela Agostiano, Paola Semeraro, Pinalysa Cosma   +7 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Radiological Safety Concerns in the Textile Dye Industry

Journal of Scientific Research in Science
People are frequently exposed to various harmful and allergic compounds derived from textiles. One major source of persistent organic pollutants in the environment is dye wastewater from this sector.
Sameh H. Fouda, H. A. Abdel Ghany, E. S. Abd El Halim   +2 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Tailoring pH-responsive acrylic acid microgels with hydrophobic crosslinks for drug release [PDF]

, 2015
Amphiphilic microgels based on the hydrophilic acrylic acid (AA) and hydrophobic crosslinks of different compositions were synthesised using a lab-on-a-chip device. The microgels were formed by polymerising hydrophobic droplets.
Georgiou, T. K., Lu, B., Pamme, N., Tarn, M. D.   +3 more
core   +2 more sources

Studies on Disperse Dyes XIV

Journal of Synthetic Organic Chemistry, Japan, 1959
Synthetic studies were made on 1-hydroxy-4-anilinoanthraquinone, 1-hydroxy-4-(p-toluidino) anthraquinone, 1-hydroxy-4-(m-hydroxymethylanilino) anthraquinone, 1-amino-4-anilinoanthraquinone, 1-amino-4-(p-toluidino) anthraquinone and 1-amino-4-(m-hydroxymethylanilino) anthraquinone.In connection with these syntheses, 1, 4-bis-anilinoanthraquinone, 1, 4 ...
KO NAIKI, Katsuo NOGUCHI
openaire   +3 more sources

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source