Results 91 to 100 of about 2,738,174 (354)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

STUDY OF THE DISPERSE EFFECT OF POLYMERIC SURFACE-ACTIVE SUBSTANCES IN ACRYLIC DISPERSIONS USED FOR PAINTING OIL WELL ARMATURE

Известия Томского политехнического университета: Инжиниринг георесурсов, 2019
The relevance of the work is caused by the need to develop new environmentally friendly water-dispersed paints with increased operating life, according to the strict requirements of PJSC «Rosneft» to protect wellhead valves of oil wells against ...
Antonina N. Dyuryagina, Aida A. Lutsenko, Vitaliy Yu. Tyukanko   +2 more
doaj   +1 more source

Dispersive wave emission from dark solitons in microresonator-based Kerr frequency combs [PDF]

arXiv, 2015
Taking advantage of an extended Lugiato--Lefever equation with third-order dispersion, we numerically show that dark cavity solitons formed in normal dispersion of microresonators are capable of emitting dispersive waves in both normal and anomalous dispersion regions, resembling the behavior of the commonly encountered bright cavity solitons.
arxiv  

Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs

Pharmaceutics, 2018
Over the past decades, a large number of drugs as well as drug candidates with poor dissolution characteristics have been witnessed, which invokes great interest in enabling formulation of these active ingredients.
Xingwang Zhang, Huijie Xing, Yue Zhao, Zhiguo Ma   +3 more
semanticscholar   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Pruning to Increase Taylor Dispersion in Physarum polycephalum Networks

, 2016
How do the topology and geometry of a tubular network affect the spread of particles within fluid flows? We investigate patterns of effective dispersion in the hierarchical, biological transport network formed by Physarum polycephalum.
Alim, Karen, Andrew, Natalie, Brenner, Michael P., Marbach, Sophie, Pringle, Anne   +4 more
core   +1 more source

The effect of horizontal pay dispersion on the effectiveness of performance-based incentives [PDF]

, 2020
In response to general calls for increased transparency in society, pay transparency policies are growing in importance. Given that pay transparency unavoidably gives employees the opportunity to make comparisons between themselves and others, in this ...
Grabner, Isabella, Martin, Melissa A.
core  

Turbulent dispersion in cloud-topped boundary layers [PDF]

, 2009
Compared to dry boundary layers, dispersion in cloud-topped boundary layers has received less attention. In this LES based numerical study we investigate the dispersion of a passive tracer in the form of Lagrangian particles for four kinds of atmospheric
Heus, T., Jonker, H.J.J., Verzijlbergh, R.A., Vilà-Guerau de Arellano, J.   +3 more
core   +4 more sources

A preliminary study on dispersions of fatigue properties of materials [PDF]

arXiv, 2016
Static mechanical properties (e.g. elastic modulus) and fatigue properties of a material all have dispersions. Material inhomogeneity (it can be characterized well by the dispersion of elastic modulus) is the internal factor of dispersions of fatigue properties and the dispersion of the load is the external factor.
arxiv  

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source