Results 21 to 30 of about 638,439 (343)
FEBS Letters, EarlyView.In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali +3 more
wiley +1 more source
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
The displaced disks problem via symplectic topology [PDF]
, 2013 We prove that a $C^0$--small area preserving homeomorphism of a closed surface with vanishing mass flow can not displace a topological disk of large area. This resolves the displaced disks problem posed by F. B\'eguin, S. Crovisier, and F. Le Roux.
arxiv +1 more source
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Heterogeneous Effects of Job Displacement on Earnings [PDF]
arXiv, 2020 This paper considers how the effect of job displacement varies across different individuals. In particular, our interest centers on features of the distribution of the individual-level effect of job displacement. Identifying features of this distribution is particularly challenging -- e.g., even if we could randomly assign workers to be displaced or ...
arxiv
Measuring Total Transverse Reference-free Displacements of Railroad Bridges using 2 Degrees of Freedom (2DOF): Experimental Validation [PDF]
arXiv, 2021 Railroad bridge engineers are interested in the displacement of railroad bridges when the train is crossing the bridge for engineering decision making of their assets. Measuring displacements under train crossing events is difficult. If simplified reference-free methods would be accurate and validated, owners would conduct objective performance ...
arxiv
FEBS Letters, EarlyView.In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri +8 more
wiley +1 more source
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
Internal displacement beyond 2018: the road ahead
Forced Migration Review, 2018 The statistics and the challenges around internal displacement are daunting. However, much has been learned since the Guiding Principles on Internal Displacement were launched in 1998.
Alexandra Bilak, Avigail Shai
doaj
, 2014 Given a functor $p:E \rightarrow B$ and an object $e \in E$ , we define a \emph{displacement} of $e$ along a morphism $\varepsilon: p(e) \rightarrow b$, as a map $e \rightarrow \nabla_\varepsilon(e)$ satisfying a universal property analogue to that of a \emph{cocartesian lifting} (pushforward) \emph{ la} B nabou-Grothendieck-Street.
openaire +3 more sources