Results 41 to 50 of about 183,763 (314)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Influence of Preconditioned Stratospheric State on the Surface Response to Displacement and Split Sudden Stratospheric Warmings

open access: yesGeophysical Research Letters, 2023
Sudden stratospheric warmings (SSWs) can affect tropospheric weather and climate, while the factors affecting the surface response to SSWs are not fully understood.
Pengkun Yang, Ming Bao, Xuejuan Ren
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

To Clarify Decision on Action of Concentrated Force to Elastic Quarter-Space for Arbitrary Poisson’s Ratio

open access: yesНаука и техника, 2022
Previously, the author obtained an analytical solution for determining the vertical displacements of the homogeneous isotropic quarter-space face, which is affected by a vertical concentrated force.
S. V. Bosakov
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Performance Assessment of a Renovated Precast Concrete Bridge Using Static and Dynamic Tests

open access: yesApplied Sciences, 2020
The article presents the development of a SHM (Structural Health Monitoring) strategy intended to confirm the improvement of the load-bearing capacity of a bridge over the Ružín Dam using static and dynamic load tests, as well as numerical simulations ...
Milan Sokol   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

ANALYSIS OF POINT CONTACTS USING THE COMBINED BOUSSINESQ-CERRUTI PROBLEM [PDF]

open access: yesFiabilitate şi Durabilitate, 2017
For "non-conforming" contact where deformations are small enough compared to body dimensions, the theoretical elasticity will apply to the closed contact defined by the contact area.The tension can be calculated by considering each body as a solid ...
Stefan GHIMISI
doaj  

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