Results 121 to 130 of about 1,239,497 (308)
Integrated land capability for ecological sustainability of on-site sewage treatment systems [PDF]
, 2005 The research project was formulated to solve serious environmental and possible public health problems in rural and regional areas caused by the common failure of soil disposal systems used for application of effluent from on-site domestic sewage ...
Al-Shiekh Khalil, Wael R.
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
The Costs of Disposal and Recycling. An Application to Italian Municipal Solid Waste Services [PDF]
The paper investigates the costs of waste disposal and recycling services by using a well-behaved Composite cost function model. Our estimates on a unique sample of more than 500 Italian municipalities highlight that the refuse collection technology ...
Davide Vannoni +3 more
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The effect of heat compression on mechanical behaviour and moisture content of pineapple leaf fibre and sugarcane bagasse waste for plate disposal [PDF]
, 2014 The waste from farming and industry could be reduced and used as raw materials in construction to achieve sustainable technologies. This study focuses on the use of waste products from the pineapple leaf and sugarcane bagasse as compounds in replacing
Sabdin, Saiful Din Sabdin
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Nuclear waste disposal in space [PDF]
Work on nuclear waste disposal in space conducted by the George C. Marshall Space Flight Center, National Aeronautics and Space Administration, and contractors are reported. From the aggregate studies, it is concluded that space disposal of nuclear waste
Burns, R. E. +3 more
core +1 more source
Gaps in Basic Workers’ Rights: Measuring International Adherence to and Implementation of the Organization’s Values With Public ILO Data [PDF]
, 2003 Conceptualizes and measures numerically the gap between the real and the ideal world of basic workers’ rights with the help of the ratification, reporting, supervisory and complaints data at the disposal of the ...
Böhning, W. R. +1 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Pharmacoepidemiology(1) Background: Although Sri Lanka is a developing country and boasts of having a well-established healthcare system along with good healthcare indices, we are still lagging in certain aspects of healthcare.
Pramila G. Chandrasena +2 more
doaj +1 more source