Results 41 to 50 of about 31,776 (299)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook +6 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Managing Disposal of Unwanted Pharmaceuticals at Health Facilities in Tanzania: A case of Dar es salaam Region Public Health Facilities [PDF]
, 2011 In the public sector medicines are the property of the state, for which strict accounting procedures to write-off the unwanted pharmaceutical stock are necessary (Public Finance Act & Regulations, 2004).
Matiko, Damas
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Project W-049H disposal facility test report
, 1995 The purpose of this Acceptance Test Report (ATR) for the Project W-049H, Treated Effluent Disposal Facility, is to verify that the equipment installed in the Disposal Facility has been installed in accordance with the design documents and function as ...
Buckles, D. I.
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Upgrading of a Tailings Management Facility for the Disposal of Dry Stack Tailings
Materials Proceedings, 2022 In every mine in the world, the result of the process is a slurry material called tailings. Today, more than ever before, the mining industry is looking for technical solutions to dewater mine tailings to eliminate the risk of tailings dam failures.
Dimitris Dimitriadis +2 more
doaj +1 more source
Integrated Disposal Facility FY2011 Glass Testing Summary Report [PDF]
, 2011 Pacific Northwest National Laboratory was contracted by Washington River Protection Solutions, LLC to provide the technical basis for estimating radionuclide release from the engineered portion of the disposal facility (e.g., source term). Vitrifying the
Bacon, Diana H. +7 more
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Community-based medication disposal pilot initiative in southwest tribal communities
Injury Epidemiology, 2021 Background Misuse and abuse of prescription drugs including opioids has been a driving force behind the drug overdose epidemic plaguing communities across the USA for more than two decades.
Isaac Ampadu +6 more
doaj +1 more source