Results 51 to 60 of about 31,776 (299)

Management of Medicines Wastage, Returned Medicines and Safe Disposal in Malaysian Community Pharmacies: A Qualitative Study

Frontiers in Medicine, 2022
IntroductionIn supplying medicines to patients and consumers waste can occur in prescribing, dispensing, and leftover stages. Pharmacists in community pharmacies play a crucial role in dispensing and should share information on appropriate medicines ...
Kah Mun Chong, Kingston Rajiah, David Chong, Mari Kannan Maharajan   +3 more
doaj   +1 more source

Conceptual Design Report for Remote-Handled Low-Level Waste Disposal Facility [PDF]

, 2010
This conceptual design report addresses development of replacement remote-handled low-level waste disposal capability for the Idaho National Laboratory. Current disposal capability at the Radioactive Waste Management Complex is planned until the facility
null David Duncan, null Joan Connolly, null Margaret Hinman, Connolly, Joan, null Charles Marcinkiewicz, Harvego, Lisa, Marcinkiewicz, Charles, null Gary Mecham, Mecham, Gary, null Lisa Harvego, Duncan, David, Hinman, Margaret   +11 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

A conceptual study on the repackaging of spent nuclear fuel from pressurized water reactors

Nuclear Engineering and Technology
Spent nuclear fuel (SNF) is stored in nuclear power plants for a certain duration, transported to an interim storage facility, and finally repackaged in a disposal canister at an encapsulation plant for final disposal.
Sang-Hwan Lee, Chang-Min Shin, Hyungoo Kang, Seung-Hyun Kim, Tae Chul Moon, Chun-Hyung Cho   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Alternative locations feasibility for development of final disposal site (TPA) in Semarang Regency [PDF]

E3S Web of Conferences
Semarang Regency consists of 19 sub-districts, 27 sub-districts, and 208 villages with a population of 1,068,492 people according to BPS Semarang Regency. Semarang Regency has a final disposal site (TPA), namely the TPA Blondo, with an existing land area
Anggraini Pratamanintyas, Nur Fadilah Hasna, Astuti Kristiana Dwi, Yesiana Reny, Septiarani Bintang   +4 more
doaj   +1 more source

AHP comparative analysis of construction and demolitio (C&D) waste recycling scenarios: The case of Beijing [PDF]

E3S Web of Conferences, 2019
As construction waste production in Beijing has increased significantly, there is an urgent demand to manage and dispose it in a more economical and environmentally-friendly way.
Wang Guiqin, Zhang Hongyu, Cheng Wei, Zhou Fei, Yabei Feng   +4 more
doaj   +1 more source

Atmospheric Pathway Screening Analysis for Saltstone Disposal Facility Vault 4 [PDF]

, 2004
A sequential screening process using a methodology developed by the National Council on Radiation Protection and Measurements, professional judgment and process knowledge has been used to produce a list of radionuclides requiring detailed analysis to ...
COOK, JAMES
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source