Results 1 to 10 of about 1,307,948 (295)
mAbs, 2021 Understanding the pharmacokinetic (PK) properties of a drug, such as clearance, is a crucial step for evaluating efficacy. The PK of therapeutic antibodies can be complex and is influenced by interactions with the target, Fc-receptors, anti-drug ...
Boris Grinshpun +6 more
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Clinical Sphingolipids Pathway in Parkinson’s Disease: From GCase to Integrated-Biomarker Discovery
Cells, 2022 Alterations in the sphingolipid metabolism of Parkinson’s Disease (PD) could be a potential diagnostic feature. Only around 10–15% of PD cases can be diagnosed through genetic alterations, while the remaining population, idiopathic PD (iPD), manifest ...
Ali Esfandiary +3 more
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Biosynthetic Strategies for Macrocyclic Peptides
Molecules, 2021 Macrocyclic peptides are predominantly peptide structures bearing one or more rings and spanning multiple amino acid residues. Macrocyclization has become a common approach for improving the pharmacological properties and bioactivity of peptides.
Wei Wang, S. Cyrus Khojasteh, Dian Su
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Pharmaceutics, 2023 Overcoming the blood–brain barrier (BBB) remains a significant challenge with regard to drug delivery to the brain. By incorporating targeting ligands, and by carefully adjusting particle sizes, nanocarriers can be customized to improve drug delivery ...
Weisen Zhang +6 more
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Pharmaceutics, 2020 The aim of this paper was to investigate whether a surface coating technique could be developed that can predict the phase behavior of amorphous solid dispersions (ASDs) coated on beads. ASDs of miconazole (MIC) and poly(vinylpyrrolidone-co-vinyl acetate)
Eline Boel +2 more
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Development of Polymeric Nanoparticles for Blood–Brain Barrier Transfer—Strategies and Challenges
Advanced Science, 2021 Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to treat with current drugs as their delivery efficacy to the brain is severely hampered by the presence of the blood–brain barrier (BBB).
Weisen Zhang +4 more
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Frontiers in Pharmacology, 2022 Buprenorphine (BUP) is a potent opioid analgesic that is widely used for severe pain management and opioid replacement therapy. The oral bioavailability of BUP, however, is significantly limited by first-pass metabolism.
Tim Quach +8 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2016 Purpose: Current practices applied to mouse pharmacokinetic (PK) studies often use large numbers of animals with sporadic or composite sampling that inadequately describe PK profiles.
Nita J Patel +9 more
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, 2013 This is a contribution to the encyclopedia of systems biology on ...
Hüttemann, Andreas, Kaiser, Marie I.
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Pharmaceutics, 2020 Targeted delivery of nucleic acids to lymph nodes is critical for the development of effective vaccines and immunotherapies. However, it remains challenging to achieve selective lymph node delivery.
Danijela Zukancic +5 more
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