Results 41 to 50 of about 6,509 (259)

Cardiovascular Toxicities of Ibrutinib: A Pharmacovigilance Study Based on the United States Food and Drug Administration Adverse Event Reporting System Database

Pharmaceuticals, 2023
Background: Although ibrutinib has been widely used to treat haematological malignancies, many studies have reported associated cardiovascular events. These studies were primarily animal experiments and clinical trials.
Yi Zheng, Xiaojing Guo, Chenxin Chen, Lijie Chi, Zhijian Guo, Jizhou Liang, Lianhui Wei, Xiao Chen, Xiaofei Ye, Jia He   +9 more
doaj   +1 more source

The rain feels different under the same umbrella: Experiences with poverty across LGBTQ subgroups

American Journal of Community Psychology, EarlyView.
Abstract Population‐based survey data have demonstrated that LGBTQ communities report varying rates of economic insecurity, yet very little research directly assesses how pathways into and experiences with poverty look different among subgroups at the intersections of sexual orientation and gender identity (SOGI).
Bianca D. M. Wilson, Lillian Nguyen
wiley   +1 more source

Immigrant mental health, safe work, discrimination, and state policies: From racism and xenophobia to health equity

American Journal of Community Psychology, EarlyView.
Abstract An ecological model was developed to examine the pathways linking immigration state policies to physically safe work conditions and work volition, interpersonal discrimination, and mental health distress. The ecological framework was tested among two subsamples totaling 529 Latinx immigrant participants: (1) immigrants who resided in states ...
Germán A. Cadenas, Thanharat Silamongkol, H. Kenny Nienhusser, Fiorella L. Carlos Chavez, Cristalís Capielo Rosario, Lucas Torres, Oswaldo Moreno   +6 more
wiley   +1 more source

Disproportionality analysis of off-label intravitreal bevacizumab in the FDA Adverse Event Reporting System database

Therapeutic Advances in Drug Safety
Background: Bevacizumab, an anti-vascular endothelial growth factor agent initially approved for cancer treatment, is widely used off-label in retinal vascular diseases; however, this use may carry safety risks, particularly when evidence from controlled
Homero Contreras-Salinas, Janet Cristina Vázquez-Beltrán, Gisela García-Sánchez, Sebastian Quirarte-Justo, Sarahí del Carmen Gómez-Macías, Lourdes Yolotzin Rodríguez-Herrera   +5 more
doaj   +1 more source

Cardiovascular Toxicity Associated With Bispecific Antibodies in Hematological Malignancies: A Comprehensive Pharmacovigilance Analysis

American Journal of Hematology, EarlyView.
ABSTRACT Cardiovascular adverse events (CVAEs) associated with bispecific T‐cell engaging antibodies (BsAbs) have not been systematically investigated across approved agents. In this disproportionality analysis of FAERS (December 2014–September 2025), reports listing BsAbs as the primary suspected drug (n = 7647) were compared with all other drugs in ...
Malak Munir, Ahmed Sayed, Dae Hyun Lee, Sanam Ghazi, Mustafa M. Houmsse, Saad Badat, Abdul Moeed, Avirup Guha, Daniel Addison, Narendranath Epperla   +9 more
wiley   +1 more source

The cranial, mandibular, and hyoid anatomy of softshell turtles (Trionychidae): A revised character list for phylogenetic analysis

The Anatomical Record, EarlyView.
Abstract Softshell turtles (Pan‐Trionychidae) are an early branching clade of hidden‐necked turtles (Cryptodira) with a rich fossil record extending back to the Early Cretaceous. The evolutionary history of softshell turtles is still unresolved because of their conservative morphology combined with high levels of polymorphism related to morphological ...
Léa C. Girard, Walter G. Joyce
wiley   +1 more source

Neoplasm Adverse Events Associated With Anti‐Type 2 Biologics: An FAERS Database Pharmacovigilance Analysis Study

Cancer Medicine
Background Biologics targeting Type 2 immune responses, such as omalizumab (anti‐IgE), dupilumab (anti‐interleukin‐4 receptor alpha, anti‐IL‐4Rα), benralizumab (anti‐IL‐5R), reslizumab, and mepolizumab (anti‐IL‐5), are increasingly used clinically ...
Wen Lyu, Rui Xu, Lin Chen, Wenbin Lei, Changhui Chen, Jiaqi Liao, Xingyu Lin, Renqiang Ma, Weiping Wen, Hang Li   +9 more
doaj   +1 more source

Charting the pitfalls of disproportionality analysis

Background: Disproportionality analysis is used by many pharmacovigilance organizations for detecting and assessing signals of potential adverse drug reactions. However, its goal is often misunderstood and the approach misapplied, leading to erroneous conclusions due to neglected violated assumptions.Objective: To illustrate how the simplistic use and ...
Michele Fusaroli, Daniele Sartori, Eugène van Puijenbroek, G. Niklas Norén   +3 more
openaire   +1 more source

Rethinking brachycephaly: Anatomical implications and health considerations in lagomorphs

The Anatomical Record, EarlyView.
Abstract Brachycephaly in domestic rabbits is increasingly perceived by welfare organizations as associated with significant health complications, particularly oral pathologies. Despite this perception, comparative anatomical research into rabbit brachycephaly is limited compared to that of dogs and cats, compelling an in‐depth examination of its ...
Helaina Cressy, Alice Nishigaki, Matthew C. Gage, Renato L. Previdelli   +3 more
wiley   +1 more source

New Adverse Drug Reaction Signals from 2017 to 2021—Genuine Alerts or False Alarms?

Pharmacy
Spontaneous adverse events reporting systems are used internationally to flag new or unexpected adverse drug reactions (ADRs). Disproportionality analysis is a recognised technique, but false alarms may arise.
Yoon Kong Loke, Katharina Mattishent, Navena Navaneetharaja   +2 more
doaj   +1 more source