Results 21 to 30 of about 6,509 (259)

Suspected Adverse Drug Reactions Related to Breast Cancer Chemotherapy: Disproportionality Analysis of the Brazilian Spontaneous Reporting System

Frontiers in Pharmacology, 2019
Spontaneous reporting systems may generate a large volume of information in real world conditions with a relatively low cost. Disproportionality measures are useful to indicate and quantify unexpected safety issues associated with a given drug-event pair
Flávia Campos Barcelos, Guacira Corrêa de Matos, Mario Jorge Sobreira da Silva, Fabrício Alves Barbosa da Silva, Elisangela da Costa Lima   +4 more
doaj   +1 more source

Analysis of disproportionation process of trifluoroethylene mixtures

Journal of Loss Prevention in the Process Industries, 2018
Abstract Trifluoroethylene (HFO-1123) and its mixtures are useful as the next generation refrigerants because their global warming potential (GWP) are lower than that of those ordinarily used. HFO-1123, however, has the potential to disproportionate explosively as does tetrafluoroethylene.
Tetsuo Otsuka, Katsuya Ueno, Hidekazu Okamoto, Masamichi Ippommatsu, Ritsu Dobashi   +4 more
openaire   +1 more source

Comparison of indices of disproportionality in PR systems [PDF]

Computer Science Journal of Moldova, 2012
Comparative analysis of 12 indices of disproportionality by such characteristics as: metric, definition domain, representation uniformity, invariance and utilization field, is done.
Ion Bolun
doaj  

A real-world disproportionality analysis of Rucaparib: Post-marketing Pharmacovigilance Data

BMC Cancer, 2023
Background Rucaparib has been approved for the maintenance treatment of adult patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer. However, the long-term safety of rucaparib in large sample population was unknown. The
Qilin Zhang, Yiling Ding, Yamin Shu, Jing Chen   +3 more
doaj   +1 more source

Pharmacological Evaluation of Signals of Disproportionality Reporting Related to Adverse Reactions to Antiepileptic Cannabidiol in VigiBase

Pharmaceuticals, 2023
Cannabidiol is the first cannabis-derived drug approved for the treatment of Lennox–Gastaut syndrome, Dravet syndrome, and Tuberous Sclerosis Complex. In the current study, we performed a descriptive analysis followed by a disproportionality analysis of ...
Fabrizio Calapai, Carmen Mannucci, Liana McQuain, Francesco Salvo   +3 more
doaj   +1 more source

The reporting of disproportionality analysis in pharmacovigilance: spotlight on the READUS-PV guideline

Frontiers in Pharmacology
Disproportionality analyses are the most-commonly used study design used in the post-marketing phase to detect suspected adverse drug reactions in individual case safety reports.
Michele Fusaroli, Francesco Salvo, Francesco Salvo, Charles Khouri, Charles Khouri, Emanuel Raschi   +5 more
doaj   +1 more source

Assessing drug-associated adverse events of spontaneous abortion or fetal death: A disproportionality analysis based on FDA adverse event reporting system

Pakistan Journal of Pharmaceutical Sciences
Background: Spontaneous abortion and fetal death represent significant reproductive health challenges, affecting approximately 10-20% of recognized pregnancies.
Huisheng Liang, Luying Li, Weihong Lu, Fei Zhang   +3 more
doaj   +1 more source

Quantifying the Regional Disproportionality of COVID-19 Spread: Modeling Study

JMIR Formative Research
BackgroundThe COVID-19 pandemic has caused serious health, economic, and social consequences worldwide. Understanding how infectious diseases spread can help mitigate these impacts.
Kenji Sasaki, Yoichi Ikeda, Takashi Nakano   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Using disproportionality analysis to explore the association between periostitis and triazole antifungals in the FDA Adverse Event Reporting System Database

Scientific Reports, 2023
Though triazole antifungals are the first choice for preventing and treating invasive fungal infections, periostitis caused by voriconazole has been described in emerging case reports; however, no studies exist on this association in real-world clinical ...
Hailong Li, Miao Zhang, Xuefeng Jiao, Yu Zhu, Yan Liu, Linan Zeng, Huiqing Wang, Lei Zhang, Wei Zhang, Lingli Zhang   +9 more
doaj   +1 more source