Results 11 to 20 of about 23,074,058 (199)

Charting the pitfalls of disproportionality analysis

Background: Disproportionality analysis is used by many pharmacovigilance organizations for detecting and assessing signals of potential adverse drug reactions. However, its goal is often misunderstood and the approach misapplied, leading to erroneous conclusions due to neglected violated assumptions.Objective: To illustrate how the simplistic use and ...
Michele Fusaroli, Daniele Sartori, Eugène van Puijenbroek, G. Niklas Norén   +3 more
openaire   +2 more sources

Drug-induced agranulocytosis: a disproportionality analysis and umbrella review

Frontiers in Pharmacology
BackgroundDrug-induced agranulocytosis (DIA) is a rare but life-threatening hematologic disorder that demands increased clinical and research attention. This study aimed to provide the current overview of DIA for clinical guidance.MethodsUsing real-world
Yajie Lu, Yajie Lu, Bin Wu, Bin Wu, Kunyu Li, Kunyu Li, Zhonglin Liu, Zhonglin Liu, Yuxi Chen, Yuxi Chen, Ting Xu, Ting Xu   +11 more
doaj   +3 more sources

Osimertinib-related myotoxicity: a disproportionality analysis of the FDA adverse event reporting system

BMC Cancer
Background Osimertinib is a third-generation epidermal growth factor receptor tyrosine kinase inhibitor that has been widely applied as a standard first-line treatment in advanced non-small cell lung cancer.
Yaqian Tan, Qi Song
doaj   +2 more sources

Finite element analysis of disproportionate regions [PDF]

Proceedings of the Second International Symposium of Trans Black Sea Region on Applied Electromagnetism (Cat. No.00TH8519), 2002
Summary form only given. The paper deals with the problem of the electromagnetic field analysis in incommensurable regions. These are cases when there is a need for detailed field calculation in a small region, which is a part of larger one.
R. Stancheva, I. Latcheva
openaire   +1 more source

Disproportionality analysis results of signals.

, 2022
Disproportionality analysis results of signals.
Sunny Park (345283), Young Joo Byun (13162535), So Hyang Park (13162532), Soo An Choi (9182922)   +3 more
core   +1 more source

Thermodynamic analysis on disproportionation process of cyclohexylamine to dicyclohexylamine [PDF]

Polish Journal of Chemical Technology, 2021
Abstract This work deals with a study of the effect of temperature on the cyclohexylamine disproportionation to dicyclohexylamine, conjointly with the thermodynamic analysis of this process. The laboratory experiments were carried out in a glass tubular continuous-flow reactor in a gaseous phase at the reaction ...
Roman Valeš, Bohumír Dvořák, Jiří Krupka   +2 more
openaire   +1 more source

Charting and Sidestepping the Pitfalls of Disproportionality Analysis. [PDF]

Drug Saf
Disproportionality analysis is used by many pharmacovigilance organizations for detecting and assessing signals of potential adverse drug reactions. However, its goal is often misunderstood and the approach misapplied, leading to erroneous conclusions due to neglected violated assumptions.
Fusaroli M, Sartori D, van Puijenbroek EP, Norén GN.   +3 more
europepmc   +3 more sources

Analysis of disproportionation process of trifluoroethylene mixtures

Journal of Loss Prevention in the Process Industries, 2018
Abstract Trifluoroethylene (HFO-1123) and its mixtures are useful as the next generation refrigerants because their global warming potential (GWP) are lower than that of those ordinarily used. HFO-1123, however, has the potential to disproportionate explosively as does tetrafluoroethylene.
Tetsuo Otsuka, Katsuya Ueno, Hidekazu Okamoto, Masamichi Ippommatsu, Ritsu Dobashi   +4 more
openaire   +1 more source

Assessing drug-associated adverse events of spontaneous abortion or fetal death: A disproportionality analysis based on FDA adverse event reporting system

Pakistan Journal of Pharmaceutical Sciences
Background: Spontaneous abortion and fetal death represent significant reproductive health challenges, affecting approximately 10-20% of recognized pregnancies.
Huisheng Liang, Luying Li, Weihong Lu, Fei Zhang   +3 more
doaj   +1 more source

Pre-Kindergarten education as a possible solution to lessen the problem of disproportionality [PDF]

, 2013
textThe increased racial and ethnic diversity in the U.S. has resulted in a greater number of minority children in the classroom. Misunderstanding of cultural differences of racial/ethnic minority groups can lead to a misdiagnosis of learning ...
Jaklich, Robert A.
core