Results 41 to 50 of about 466,156 (344)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Analysis of main components of Lake Toba’s water quality in different seasons

Advances in Oceanography and Limnology
Lake Toba is one of the largest lakes in North Sumatra Province, Indonesia. Its waters are used for multiple purposes, constituting an important natural and economic resource.
Yuni Puji Hastuti, Kukuh Nirmala, Manuntun Parulian Hutagaol , Dahri Tanjung, Agit Kriswantriyono, Wildan Nurussalam, Yulia Puspadewi Wulandari, Yuli Siti Fatma   +7 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Participation Versus Procedures in Non-Union Dispute Resolution [PDF]

, 2013
This study examines the resolution of conflict in non-union workplaces. Employee participation in workplace decision making and organizational dispute resolution procedures are two factors hypothesized to influence the outcomes of conflicts in the non ...
Colvin, Alexander
core   +2 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Understanding ADR [PDF]

, 2015
[Excerpt] This essay provides a concrete understanding of Alternative Dispute Resolution (ADR) by analyzing Owen Fiss’ article Against Settlement. Additionally, this essay provides insight regarding the role that the Human Resources (HR) function plays ...
Yonover, Jacqueline
core   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Spain, and the Crisis of Investment Arbitration: Extra-EU Jurisdictions as Alternative enforcement Forums

Behavior & Law Journal
The purpose of this paper is to examine the structural crisis that currently faces the international investment arbitration regime within the European Union, with particular attention to the growing incompatibility between the Energy Charter Treaty (ECT)
Jesús Alfonso Soto Pineda, Evelyn Gacitúa, Fernando González, Elena Lucas   +3 more
doaj   +1 more source

Body‐Self Unity With a New Hip or Knee: Understanding Total Joint Replacement Within an Embodiment Framework

ACR Open Rheumatology, 2019
Medical research increasingly makes use of embodiment concepts to understand how illness disrupts unity of body and self. However, few have applied embodiment concepts in total joint replacement (TJR), an effective treatment for end‐stage arthritis.
Emma C. Lape, Pamela Hudak, Aileen M. Davis, Jeffrey N. Katz   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source