Results 161 to 170 of about 4,594 (295)

We need to talk about dying. [PDF]

Br J Gen Pract
Cunha FD.
europepmc   +1 more source

Iconic Athletes and the Antivaccine Movement: An Improbable Alliance That Reinforces Science Denial. [PDF]

AJPM Focus, 2023
Silva HM.
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Unmet, Disquiet

Editor: Konstmuseet i Skövde/Skövde Art MuseumCo-Editors: Lars Kristensen & Rebecca Rouse at University of SkövdeAuthors: Thomas Oldrell, Rebecca Rouse, Lars Kristensen, Sharon Clark, Jack Hardiker, Hedvig Jalhed, Mattias Rylander, Kristoffer Åberg, David Hornwall, Katariina Poikela, WU Mingmin, Nea Landin, Gabriel Widing, Scott Cazan, Jamie Fawcus,
Fawcus, Jamie, Hansson, Susanne, Granath, Anna   +2 more
openaire   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

No public health without planetary health. [PDF]

Lancet Public Health, 2022
The Lancet Public Health.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Aggressiveness that makes one grow: a destructive or vital force in adolescence? Reflections and working hypotheses. [PDF]

Front Behav Neurosci
Demaria F, Pontillo M, Di Vincenzo C, Vicari S.   +3 more
europepmc   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Genetic Diversity and Antibiotic Resistance Paradigm of Enterobacterales in Animal-Derived Food Sources: A One Health Disquiet. [PDF]

Pathogens
Sarwar A, Aslam B, Rasool MH, Shafique M, Khurshid M, Sasanya JJ, Aljasir SF.   +6 more
europepmc   +1 more source