Results 171 to 180 of about 4,594 (295)

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

States, law, and the regulation of controversial health-related claims: consolidating a research agenda between disciplines and contexts. [PDF]

Wellcome Open Res
Cloatre E, Pickersgill M, A Atuire C, Enright M, Friesen P, Kingori P, Ndoye T, Urquiza-Haas N.   +7 more
europepmc   +1 more source

Managing Differences Among Pro-nutrition Actors on Corporate Engagement; A Response to the Recent Commentary. [PDF]

Int J Health Policy Manag, 2022
Fanzo J, Shawar YR, Shiffman J.
europepmc   +1 more source

The Disquiet of Language: a Reading of Saramago’s The Stone Raft

En su obra La balsa de piedra, José Saramago narra el desprendimiento de la península ibérica del continente europeo. La península comienza un viaje del que nadie puede conocer el fin, lo que provoca un desasosiego en sus habitantes por la incertidumbre ...
Gonzalez Canovas, Martina
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

The arrangement of the organs. [PDF]

Ann Pediatr Cardiol
Anderson RH.
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Clinical enigma: Case-based systematic review of flumazenil in the management of paradoxical reactions to midazolam - A quarter-century perspective. [PDF]

J Anaesthesiol Clin Pharmacol
Utami NP, Rachmadhianto R, Wiyono MR, Nugraha SA, Santoso AB.   +4 more
europepmc   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

A case of a cerebellar form of progressive multifocal leukoencephalopathy in a patient undergoing peritoneal dialysis. [PDF]

CEN Case Rep
Waraya Y, Habuka M, Sakurazawa C, Sakamaki Y, Ogawa A, Shimbo J, Nakamichi K, Yamamoto S, Narita I.   +8 more
europepmc   +1 more source