Results 181 to 190 of about 5,793 (279)

Experiences of integrating social prescribing link workers into primary care in England - bolting on, fitting in, or belonging: a realist evaluation. [PDF]

Br J Gen Pract
Tierney S, Westlake D, Wong G, Wong G, Turk A, Markham S, Gorenberg J, Reeve J, Mitchell C, Husk K, Redwood S, Pope C, Baird B, Mahtani KR.   +13 more
europepmc   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Antipsychotics, COVID-19, and Secondary Healthcare Databases: Revisiting the Pandemic. [PDF]

Int J Neuropsychopharmacol
Boland X, Dratcu L.
europepmc   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

On “Past Disquiet” and “NIRIN” A conversation between Rasha Salti, Nick Aikens, Kristine Khouri and Anthony Gardner

Parse Journal, 2021
Nick Aikens, Anthony Gardner, Kristine Khouri, Rasha Salti   +3 more
doaj  

Generating "Différance" or an Ontology That Is Same Old Same Old Comment on "The Generative Mechanisms of Financial Strain and Financial Well-Being: A Critical Realist Analysis of Ideology and Difference". [PDF]

Int J Health Policy Manag
McIntyre L, Mah CL.
europepmc   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Educational intervention for nursing professionals on palliative care: quasi-experimental study. [PDF]

Rev Lat Am Enfermagem
Barros JA, Ferreira TFA, Bolela F, Pan R, Toffano SEM, Nicolussi AC.   +5 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Rejoinder to Commentaries on: On the Uses and Abuses of Regression Models: A Call for Reform of Statistical Practice and Teaching. [PDF]

Stat Med
Carlin JB, Moreno-Betancur M.
europepmc   +1 more source