Results 191 to 200 of about 35,999 (288)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Living on the Edge: A Cocreated Teaching-Learning Journey. [PDF]

Nurs Sci Q
Ursel KL.
europepmc   +1 more source

Editorial Commitment to Trust and Integrity in Science: Implications for Pain and Anesthesiology Research. [PDF]

J Pain Res
Palermo TM, Bouhassira D, Davis KD, Hemmings Jnr HC, Hurley RW, Katz J, Pandit J, Price T, Schatman ME, Schwarz SKW, Turk D, Van de Velde M, Wiles M, Yaksh T, Yarnitsky D.   +14 more
europepmc   +3 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Editorial commitment to trust and integrity in science: implications for pain and anaesthesiology research. [PDF]

Anaesthesia
Palermo TM, Bouhassira D, Davis KD, Hemmings HC, Hurley RW, Katz J, Pandit JJ, Price TJ, Schatman ME, Schwarz SKW, Turk DC, Van de Velde M, Wiles MD, Yaksh TL, Yarnitsky D.   +14 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Speciality grand challenge: next steps for coaching? Some existing and emerging issues. [PDF]

Front Sports Act Living
Collins D.
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

How cancer arises: Genetics releases, plasticity creates, genetics stabilizes. [PDF]

Proc Natl Acad Sci U S A
Frank SA.
europepmc   +1 more source

A Disquiet Find: Anabolic-androgenic steroids and Vanishing Bile Duct Syndrome. [PDF]

Hepatol Forum, 2020
Kalal C, Wagh A, Patel A, Joshi H, Surude R, Singh A, Bhatia S, Bhatt C.   +7 more
europepmc   +1 more source