Results 61 to 70 of about 4,594 (295)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

From mist to mist — through mist: translating «this kind of non-book»

open access: yesAbriu: Estudos de Textualidade do Brasil, Galicia e Portugal, 2016
In Italy there are presently five translations of The Book of Disquiet, each one featuring a very different text: either because the base edition from which each translator set off is different; or because the translators had a different attitude towards
Valeria Tocco
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Hermeneutics of Practice: Philosophical Hermeneutics and the Epistemology of Participation

open access: yesJournal of Applied Hermeneutics, 2015
Gadamer’s “Philosophical Hermeneutics” leaves several unresolved questions inviting further development. (1) If scientific methodology is no longer the counter-balance to questions of procedure in the humanities, what can hermeneutics offer the ...
J.R. Nicholas Davey
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Post Inflation Targeting Monetary Policy: A Study of Britain, Japan and the United States [PDF]

open access: yesExpert Journal of Economics, 2014
There is now considerable disquiet about the appropriate monetary strategy that central banks should follow in the aftermath of the global financial crisis.
Mehdi Siamak MONADJEMI, John LODEWIJKS
doaj  

As Únicas Coisas Nobres Que a Vida Contém

open access: yesMatLit, 2013
In Livro do Desassossego (The Book of Disquiet) we can read that "To see and to listen are the only noble things that life comprehends. All other senses are plebeian and carnal." What happens if in our approach to Pessoa we read this affirmation ...
Osvaldo Manuel Silvestre
doaj   +1 more source

Economic progress, social disquiet: the modern paradox [PDF]

open access: yes, 2020
Surveys of social attitudes are revealing a perhaps unprecedented paradox: a booming economy but persistent community disquiet. The puzzling coincidence is fuelling interest in what is perhaps the ultimate public policy question: is life getting better ...
Richard Eckersley
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

To Disquiet a Giant: Cuba, the United States, and the World

open access: yesLatin American Research Review, 2019
This essay reviews the following works:   From Lenin to Castro, 1917–1959: Early Encounters between Moscow and Havana. By Mervyn J. Bain. Lanham, MD: Lexington Books, 2013. Pp. vii + 159. $55.99 hardcover. ISBN: 9780739181102.
Louis A. Pérez Jr.
doaj   +1 more source

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