Results 141 to 150 of about 1,077,984 (269)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Circadian rhythm: The hidden "puppet master" behind musculoskeletal disorders. [PDF]

J Orthop Translat
Zhong S, Cheng Y, Li F, Li D, Chang X, Zhang B, Qi P, Li N, Xie X.   +8 more
europepmc   +1 more source

Disruptive Immunology [PDF]

Clinical Cancer Research, 2016
openaire   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Acute Capitellum Fracture with Distal Radio-ulnar Joint Disruption: An Atypical Variant of an Essex Lopresti Injury - Case Report. [PDF]

J Orthop Case Rep
Sha AAMA, Jain A, Gulihar A, Gokaraju K.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Studying endocrine disrupting chemicals from molecular targets to mixture model approach: lessons from the thyroid model.

J Clin Endocrinol Metab
Coperchini F, Greco A, Franchi E, Denegri M, Rotondi M.   +4 more
europepmc   +1 more source

Core Blood-Brain Barrier Disruption in Patients With Large Vessel Occlusion. [PDF]

Stroke
Leigh R, Valyraki N, Wang NY, Abomulay M, Ter Schiphorst A, Valls Carbó A, Hernández-Pérez M, Charbonneau F, Arquizan C, Wacongne A, Sablot D, Costalat V, Ozsancak C, Cohen C, Pasi M, Boulouis G, Yuen N, Desilles JP, Albers GW, Olivot JM, Seners P.   +20 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source