Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa [PDF]
Human Reproduction, 2015 STUDY QUESTION Are significant abnormalities of CatSper function present in IVF patients with normal sperm concentration and motility and if so what is their functional significance for fertilization success?SUMMARY ANSWER Sperm with a near absence of ...
Wardah Alasmari +2 more
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Presence and Location of CatSper 1–4, Opioid (μ, δ and κ) and CD44 Receptors in Spermatozoa from Aoudad, Iberian Ibex and Mouflon [PDF]
Veterinary Medicine and ScienceDespite the apparent progress in reproductive technologies in wild ruminant species, healthy live births have been limited. Acquiring a sound knowledge of the molecular basis of most functional aspects of spermatozoa will improve the effectiveness of ...
Alejandro Vicente‐Carrillo +6 more
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Pharmacological Targeting of Native CatSper Channels Reveals a Required Role in Maintenance of Sperm Hyperactivation [PDF]
PLoS ONE, 2009 The four sperm-specific CatSper ion channel proteins are required for hyperactivated motility and male fertility, and for Ca(2+) entry evoked by alkaline depolarization. In the absence of external Ca(2+), Na(+) carries current through CatSper channels in
Bertil Hille, Donner F Babcock
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The essential calcium channel of sperm CatSper is temperature-gated [PDF]
Nature CommunicationsThe flagellar calcium channel CatSper is essential for male fertility, as it regulates calcium influx to trigger the hyperactive motility required for sperm to fertilize the egg.
Dilip K. Swain +3 more
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ARMH2 is a cytosolic component of CatSper crucial for sperm function [PDF]
Nature CommunicationsSperm capacitation and fertilization are highly regulated by Ca2+ signaling. CatSper, a sperm-specific calcium channel, plays a crucial role in sperm hyperactivated motility and fertility by mediating Ca2+ influx into sperm.
Qingqing Zhao +21 more
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3D structure and in situ arrangements of CatSper channel in the sperm flagellum
Nature Communications, 2022 Sperm motility and male fertility requires function of the CatSper calcium channels. Here, using cryo-electron tomography, authors visualize the native in-cell 3D structure and higher-order organization of the CatSper as long zigzag rows along the sperm ...
Huafeng Wang +2 more
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Environment International, 2022 Background: Ca2+-signaling controls sperm cell functions necessary for successful fertilization. Multiple endocrine disrupting chemicals have been found to interfere with normal Ca2+-signaling in human sperm cells through an activation of the sperm ...
Anna Maria Andersson, Anders Rehfeld
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Redox Biology, 2021 To fertilize an oocyte, sperm must undergo several biochemical and functional changes known as capacitation. A key event in capacitation is calcium influx through the cation channel of sperm (CatSper).
Juan Ferreira Gregorio +2 more
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Sperm hyperactivation and the CatSper channel: current understanding and future contribution of domestic animals [PDF]
Journal of Animal Science and TechnologyIn female tract, mammalian sperm develop hyperactivated motility which is a key physiological event for sperm to fertilize eggs. This motility change is triggered by Ca2+ influx via the sperm-specific Ca2+ channel, CatSper.
Jae Yeon Hwang
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Activation of motility and chemotaxis in the spermatozoa [PDF]
Reproductive Medicine and BiologyBackground Sperm motility and chemotaxis are important early steps in the interaction between sperm and oocytes during fertilization. Understanding these processes is essential for their basic biological and clinical applications.
Manabu Yoshida, Kaoru Yoshida
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