ARMH2 is a cytosolic component of CatSper crucial for sperm function [PDF]
Nature CommunicationsSperm capacitation and fertilization are highly regulated by Ca2+ signaling. CatSper, a sperm-specific calcium channel, plays a crucial role in sperm hyperactivated motility and fertility by mediating Ca2+ influx into sperm.
Qingqing Zhao +21 more
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Presence and Location of CatSper 1–4, Opioid (μ, δ and κ) and CD44 Receptors in Spermatozoa from Aoudad, Iberian Ibex and Mouflon [PDF]
Veterinary Medicine and ScienceDespite the apparent progress in reproductive technologies in wild ruminant species, healthy live births have been limited. Acquiring a sound knowledge of the molecular basis of most functional aspects of spermatozoa will improve the effectiveness of ...
Alejandro Vicente‐Carrillo +6 more
doaj +3 more sources
The essential calcium channel of sperm CatSper is temperature-gated [PDF]
Nature CommunicationsThe flagellar calcium channel CatSper is essential for male fertility, as it regulates calcium influx to trigger the hyperactive motility required for sperm to fertilize the egg.
Dilip K. Swain +3 more
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The Chemosensing Role of CatSper in Mammalian Sperm: An Updated Review
Current Issues in Molecular Biology, 2023 After sperm enter the female reproductive tract, the physicochemical and biochemical microenvironment undergoes significant changes. In particular, the large changes in various ions encountered by sperm may alter the physiology of sperm, ultimately ...
Tao Luo, Sülün Ke
exaly +5 more sources
Environmental pollutants and male infertility: Effects on CatSper
Ecotoxicology and Environmental SafetyInfertility is a growing health concern among many couples worldwide. Men account for half of infertility cases. CatSper, a sperm-specific Ca2+ channel, is expressed on the cell membrane of mammalian sperm.
Dalei Zhang +2 more
exaly +5 more sources
Down-regulation of CatSper 1 and CatSper 2 genes by lead and mercury [PDF]
Environmental Toxicology and Pharmacology, 2018 In the study of the expression of CatSper genes, consideration of the effects of environmental metal toxicity is very important. Therefore, in this study, the effects of lead acetate and mercury chloride exposure on expression of CatSper genes, sperm parameters, histology of testis and prooxidant antioxidant balance (PAB) values of serum were ...
Samaneh Boroumand-Noughabi +2 more
exaly +3 more sources
Pharmacological Targeting of Native CatSper Channels Reveals a Required Role in Maintenance of Sperm Hyperactivation [PDF]
PLoS ONE, 2009 The four sperm-specific CatSper ion channel proteins are required for hyperactivated motility and male fertility, and for Ca(2+) entry evoked by alkaline depolarization. In the absence of external Ca(2+), Na(+) carries current through CatSper channels in
Donner Babcock +2 more
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CatSper channel, sperm function and male fertility [PDF]
Reproductive BioMedicine Online, 2015 A number of physiological events, such as sperm hyperactivation, chemotaxis towards the egg, capacitation and acrosome reaction, are triggered by activation of sperm ion channels in response to a diverse range of chemical cues. Cation channel of sperm (CatSper), a sperm-specific ion channel, is unique in orchestrating the events for fertilization, and ...
Singh Rajender
exaly +3 more sources
3D structure and in situ arrangements of CatSper channel in the sperm flagellum [PDF]
Nature Communications, 2022 Sperm motility and male fertility requires function of the CatSper calcium channels. Here, using cryo-electron tomography, authors visualize the native in-cell 3D structure and higher-order organization of the CatSper as long zigzag rows along the sperm ...
Yanhe Zhao +12 more
doaj +5 more sources
The Catsper channel and its roles in male fertility: a systematic review [PDF]
Reproductive Biology and Endocrinology, 2017 The Catsper channel is a sperm-specific, Ca2+-permeable, pH-dependent, and low voltage-dependent channel that is essential for the hyperactivity of sperm flagellum, chemotaxis towards the egg, capacitation and acrosome reaction.
Xiang-hong Sun +6 more
doaj +3 more sources