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The essential calcium channel of sperm CatSper is temperature-gated [PDF]
Nature CommunicationsThe flagellar calcium channel CatSper is essential for male fertility, as it regulates calcium influx to trigger the hyperactive motility required for sperm to fertilize the egg.
Dilip K. Swain +3 more
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Presence and Location of CatSper 1–4, Opioid (μ, δ and κ) and CD44 Receptors in Spermatozoa from Aoudad, Iberian Ibex and Mouflon [PDF]
Veterinary Medicine and ScienceDespite the apparent progress in reproductive technologies in wild ruminant species, healthy live births have been limited. Acquiring a sound knowledge of the molecular basis of most functional aspects of spermatozoa will improve the effectiveness of ...
Alejandro Vicente‐Carrillo +6 more
doaj +4 more sources
Pharmacological Targeting of Native CatSper Channels Reveals a Required Role in Maintenance of Sperm Hyperactivation [PDF]
PLoS ONE, 2009 The four sperm-specific CatSper ion channel proteins are required for hyperactivated motility and male fertility, and for Ca(2+) entry evoked by alkaline depolarization. In the absence of external Ca(2+), Na(+) carries current through CatSper channels in
Magdalene M Moran +2 more
exaly +3 more sources
ARMH2 is a cytosolic component of CatSper crucial for sperm function [PDF]
Nature CommunicationsSperm capacitation and fertilization are highly regulated by Ca2+ signaling. CatSper, a sperm-specific calcium channel, plays a crucial role in sperm hyperactivated motility and fertility by mediating Ca2+ influx into sperm.
Qingqing Zhao +21 more
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Environmental pollutants and male infertility: Effects on CatSper
Ecotoxicology and Environmental SafetyInfertility is a growing health concern among many couples worldwide. Men account for half of infertility cases. CatSper, a sperm-specific Ca2+ channel, is expressed on the cell membrane of mammalian sperm.
Dalei Zhang, Yangyang Yuan, Yuxin He
exaly +5 more sources
Molecular basis of the higher-order assembly of CatSper [PDF]
Proceedings of the National Academy of Sciences of the United States of AmericaCatSper serves as the primary Ca 2+ entry pathway in the principal piece of sperm flagellum and is crucial for sperm motility and fertility. Sperm lacking functional CatSper channels fail to undergo hyperactivation during fertilization, leading to complete male infertility.
Jianping Wu, Zhen Yan, Shiyi Lin
exaly +4 more sources
CatSper mediates not only chemotactic behavior but also the motility of ascidian sperm
Frontiers in Cell and Developmental Biology, 2023 Introduction: Sperm motility, including chemotactic behavior, is regulated by changes in the intracellular Ca2+ concentration, and the sperm-specific Ca2+ channel CatSper has been shown to play an important role in the regulation of intracellular Ca2 ...
Yasunori Sasakura +2 more
exaly +3 more sources
Activation of motility and chemotaxis in the spermatozoa [PDF]
Reproductive Medicine and BiologyBackground Sperm motility and chemotaxis are important early steps in the interaction between sperm and oocytes during fertilization. Understanding these processes is essential for their basic biological and clinical applications.
Manabu Yoshida, Kaoru Yoshida
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Intracellular domain of CATSPER1 could serve as a cytoplasmic platform for redox processes in mammalian sperm [PDF]
Animal BioscienceObjective Mammalian sperm acquire fertilizing ability in the female reproductive tract and develop hyperactivated motility, which is indispensable for male fertility. Hyperactivated motility is initiated by Ca2+ influx via the sperm-specific ion channel,
Jingon Kim, Jae Yeon Hwang
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Frontiers in Cell and Developmental Biology, 2023 The exclusive expression of CatSper in sperm and its critical role in sperm function makes this channel an attractive target for contraception. The strategy of blocking CatSper as a male, non-hormonal contraceptive has not been fully explored due to the ...
Guillermina M. Luque +9 more
doaj +1 more source