Results 21 to 30 of about 1,728 (186)

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm [PDF]

Frontiers in Cell and Developmental Biology, 2021
The sperm-specific Ca2+ channel CatSper registers chemical cues that assist human sperm to fertilize the egg. Prime examples are progesterone and prostaglandin E1 that activate CatSper without involving classical nuclear and G protein-coupled receptors ...
Janice K. Jeschke, Cristina Biagioni, Tobias Schierling, Isabel Viola Wagner, Isabel Viola Wagner, Frederik Börgel, Dirk Schepmann, Andreas Schüring, Alexandra E. Kulle, Paul Martin Holterhus, Michael von Wolff, Bernhard Wünsch, Verena Nordhoff, Timo Strünker, Timo Strünker, Christoph Brenker   +15 more
doaj   +2 more sources

Panax ginseng induces the expression of CatSper genes and sperm hyperactivation

Asian Journal of Andrology, 2014
The cation channel of sperm (CatSper) protein family plays important roles in male reproduction and infertility. The four members of this family are expressed exclusively in the testis and are localized differently in sperm. To investigate the effects of
Eun Hwa Park, Do Rim Kim, Ha Young Kim, Seong Kyu Park, Mun Seog Chang   +4 more
doaj   +3 more sources

Calcium Signaling Through CatSper Channels in Mammalian Fertilization

Physiology, 2010
The molecular mechanisms underlying Ca2+entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper.
Dejian Ren, Jingsheng Xia
core   +3 more sources

Canal catiónico específico del espermatozoide: CatSper

TIP Revista Especializada en Ciencias Químico-Biológicas
El canal catiónico específico del espermatozoide (CatSper) es un canal conductor de calcio esencial para regular la movilidad hiperactivada y, en última instancia, la promoción de la fertilidad en los espermatozoides. Este canal se localiza en el flagelo
Morales Otal, Adriana, Chávez Zamora, Julio C., Mendoza Sánchez, José Edwin, Rodríguez Tobón, Ahiezer, Arenas Ríos, Edith   +4 more
core   +2 more sources

Exposure to Cadmium Impairs Sperm Functions by Reducing CatSper in Mice [PDF]

Cellular Physiology and Biochemistry, 2017
Background: Cadmium (Cd), a common environmental heavy metal and endocrine disruptor, is known to exert toxic effects on the testes. However, the mechanisms accounting for its toxicity in mature spermatozoa remain unclear.
Hua-Feng Wang, Meng Chang, Ting-Ting Peng, Yi Yang, Na Li, Tao Luo, Yi-Min Cheng, Meng-Zhi Zhou, Xu-Hui Zeng, Li-Ping Zheng   +9 more
doaj   +3 more sources

The Olfactory Receptor Olfr25 Mediates Sperm Dysfunction Induced by Low-Dose Bisphenol A through the CatSper-Ca²⁺ Signaling Pathway [PDF]

Toxics
Bisphenol A (BPA), a typical endocrine disruptor, is known to have various adverse effects on the male reproductive system. However, the toxic effects and mechanisms of low-dose BPA have not yet been fully explored.
Jing Gu, Ning Zhang, Xiao Jiang, Lei Zhu, Yixia Lou, Shengqi Sun, Li Yin, Jinyi Liu   +7 more
doaj   +2 more sources

Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation

The Journal of Clinical Investigation
The infertility of many couples rests on an enigmatic dysfunction of the man’s sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of almost 2,300 ...
Samuel Young, Christian Schiffer, Alice Wagner, Jannika Patz, Anton Potapenko, Leonie Herrmann, Verena Nordhoff, Tim Pock, Claudia Krallmann, Birgit Stallmeyer, Albrecht Röpke, Michelina Kierzek, Cristina Biagioni, Tao Wang, Lars Haalck, Dirk Deuster, Jan N. Hansen, Dagmar Wachten, Benjamin Risse, Hermann M. Behre, Stefan Schlatt, Sabine Kliesch, Frank Tüttelmann, Christoph Brenker, Timo Strünker   +24 more
doaj   +2 more sources

High-throughput screening method for discovering CatSper inhibitors using membrane depolarization caused by external calcium chelation and fluorescent cell barcoding

Frontiers in Cell and Developmental Biology, 2023
The exclusive expression of CatSper in sperm and its critical role in sperm function makes this channel an attractive target for contraception. The strategy of blocking CatSper as a male, non-hormonal contraceptive has not been fully explored due to the ...
Guillermina M. Luque, Liza J. Schiavi-Ehrenhaus, Martina Jabloñski, Paula A. Balestrini, Analia G. Novero, Nicolás I. Torres, Claudia E. Osycka-Salut, Alberto Darszon, Dario Krapf, Mariano G. Buffone   +9 more
doaj   +1 more source

Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. [PDF]

PLoS ONE, 2008
The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated Ca2+ channels that are crucial for sperm hyperactivation and male fertility. All four CatSper subunits are believed to assemble into a heteromultimeric channel complex,
Xinjiang Cai, David E Clapham
doaj   +1 more source

CatSper channels are regulated by protein kinase A [PDF]

Journal of Biological Chemistry, 2018
Mammalian sperm must undergo capacitation as a preparation for entering into hyperactivated motility, undergoing the acrosome reaction, and acquiring fertilizing ability. One of the initial capacitation events occurs when sperm encounter an elevated HCO3- concentration.
Gerardo Orta, José Luis de la Vega-Beltran, David Martín-Hidalgo, Celia M. Santi, Pablo E. Visconti, Alberto Darszon   +5 more
openaire   +3 more sources