Results 21 to 30 of about 1,915 (186)

Sperm hyperactivation and the CatSper channel: current understanding and future contribution of domestic animals

Journal of Animal Science and Technology
In female tract, mammalian sperm develop hyperactivated motility which is a key physiological event for sperm to fertilize eggs. This motility change is triggered by Ca2+ influx via the sperm-specific Ca2+ channel, CatSper.
Jae Yeon Hwang
doaj   +2 more sources

SKF96365 modulates activity of CatSper channels in human sperm [PDF]

Molecular Human Reproduction, 2023
Abstract Exposure of human sperm to progesterone (P4) activates cation channel of sperm (CatSper) channels, inducing an intracellular Ca2+ concentration ([Ca2+]i) transient followed by repetitive [Ca2+]i activity (oscillations), which are believed to be functionally important.
Elis Torrezan-Nitao, Sean G Brown, Linda Lefievre, Jennifer Morris, Joao Correia, Claire V Harper, Stephen Publicover   +6 more
openaire   +4 more sources

Conserved Mechanism of Bicarbonate-Induced Sensitization of CatSper Channels in Human and Mouse Sperm [PDF]

Frontiers in Cell and Developmental Biology, 2021
To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract. A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated by membrane depolarization and intracellular alkalinization.
Juan J. Ferreira, Juan J. Ferreira, Pascale Lybaert, Lis C. Puga-Molina, Celia M. Santi, Celia M. Santi   +5 more
doaj   +2 more sources

Calcium Signaling Through CatSper Channels in Mammalian Fertilization

Physiology, 2010
The molecular mechanisms underlying Ca2+entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility.
Dejian, Ren, Jingsheng, Xia
openaire   +3 more sources

Canal catiónico específico del espermatozoide: CatSper

TIP Revista Especializada en Ciencias Químico-Biológicas
El canal catiónico específico del espermatozoide (CatSper) es un canal conductor de calcio esencial para regular la movilidad hiperactivada y, en última instancia, la promoción de la fertilidad en los espermatozoides. Este canal se localiza en el flagelo del espermatozoide y está regulado por la alcalinización, el voltaje y diferentes moléculas ...
José Edwin Mendoza-Sánchez, Julio C. Chávez-Zamora, Ahiezer Rodríguez-Tobón, Adriana Morales Otal, Edith Arenas-Ríos   +4 more
openaire   +2 more sources

Testicular toll with viral intrusion: Molecular insights into the impact of chronic HIV infection on male fertility. [PDF]

Clin Transl Med
The molecular mechanisms contributing to impaired fertility in HIV+ males remain poorly defined. Using a human immunodeficiency virus (HIV) transgenic (Tg) rat model, we demonstrate key structural and functional sperm regulators including cation channel of sperm (CatSper)1–4 channels and mitochondrial biogenesis genes were markedly downregulated ...
Hediyal TA, Stone EM, Shukri O, Schaal VL, Foroughi-Nezhad A, Devanaboyina M, Crenshaw JS, Elrefaie A, Kolli S, Davis CN, Pradhan D, Yelamanchili SV, Pendyala G.   +12 more
europepmc   +2 more sources

Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation

The Journal of Clinical Investigation
The infertility of many couples rests on an enigmatic dysfunction of the man’s sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of almost 2,300 ...
Samuel Young, Christian Schiffer, Alice Wagner, Jannika Patz, Anton Potapenko, Leonie Herrmann, Verena Nordhoff, Tim Pock, Claudia Krallmann, Birgit Stallmeyer, Albrecht Röpke, Michelina Kierzek, Cristina Biagioni, Tao Wang, Lars Haalck, Dirk Deuster, Jan N. Hansen, Dagmar Wachten, Benjamin Risse, Hermann M. Behre, Stefan Schlatt, Sabine Kliesch, Frank Tüttelmann, Christoph Brenker, Timo Strünker   +24 more
doaj   +2 more sources

Exposure to Cadmium Impairs Sperm Functions by Reducing CatSper in Mice [PDF]

Cellular Physiology and Biochemistry, 2017
Background: Cadmium (Cd), a common environmental heavy metal and endocrine disruptor, is known to exert toxic effects on the testes. However, the mechanisms accounting for its toxicity in mature spermatozoa remain unclear.
Hua-Feng Wang, Meng Chang, Ting-Ting Peng, Yi Yang, Na Li, Tao Luo, Yi-Min Cheng, Meng-Zhi Zhou, Xu-Hui Zeng, Li-Ping Zheng   +9 more
doaj   +3 more sources

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm

Frontiers in Cell and Developmental Biology, 2021
The sperm-specific Ca2+ channel CatSper registers chemical cues that assist human sperm to fertilize the egg. Prime examples are progesterone and prostaglandin E1 that activate CatSper without involving classical nuclear and G protein-coupled receptors ...
Janice K. Jeschke, Cristina Biagioni, Tobias Schierling, Isabel Viola Wagner, Isabel Viola Wagner, Frederik Börgel, Dirk Schepmann, Andreas Schüring, Alexandra E. Kulle, Paul Martin Holterhus, Michael von Wolff, Bernhard Wünsch, Verena Nordhoff, Timo Strünker, Timo Strünker, Christoph Brenker   +15 more
doaj   +1 more source

CatSper and Two-Pore channels (TPC) in GtoPdb v.2022.1 [PDF]

, 2022
CatSper channels (CatSper1-4, nomenclature as agreed by NC-IUPHAR [14]) are putative 6TM, voltage-gated, alkalinization-activated calcium permeant channels that are presumed to assemble as a tetramer of α-like subunits and mediate the current ...
Chung, Jean-Ju, Grimm, Christian M., Ren, Dejian, Clapham, David E., Garbers, David L.   +4 more
core   +1 more source