Results 21 to 30 of about 1,350 (163)
Sperm are promiscuous and CatSper is to blame… [PDF]
The EMBO Journal, 2012 The human spermatozoon is a remarkable cell. It is characterised by extremely small size, absence of most organelles, a lack of transcription or translation (DNA is tightly condensed and almost crystalline), extreme polarity and rapid motility. These unusual characteristics have presented great challenges to the application of traditional methods of ...
Barratt, Christopher L. R. +1 more
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CatSper mediates not only chemotactic behavior but also the motility of ascidian sperm
Frontiers in Cell and Developmental Biology, 2023 Introduction: Sperm motility, including chemotactic behavior, is regulated by changes in the intracellular Ca2+ concentration, and the sperm-specific Ca2+ channel CatSper has been shown to play an important role in the regulation of intracellular Ca2 ...
Taiga Kijima +6 more
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Cells, 2021 Males have evolved species-specifical sperm morphology and swimming patterns to adapt to different fertilization environments. In eutherians, only a small fraction of the sperm overcome the diverse obstacles in the female reproductive tract and ...
Jae Yeon Hwang +3 more
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Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. [PDF]
PLoS ONE, 2008 The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated Ca2+ channels that are crucial for sperm hyperactivation and male fertility. All four CatSper subunits are believed to assemble into a heteromultimeric channel complex,
Xinjiang Cai, David E Clapham
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CatSper channels are regulated by protein kinase A [PDF]
Journal of Biological Chemistry, 2018 Mammalian sperm must undergo capacitation as a preparation for entering into hyperactivated motility, undergoing the acrosome reaction, and acquiring fertilizing ability. One of the initial capacitation events occurs when sperm encounter an elevated HCO3- concentration.
Gerardo Orta +5 more
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Frontiers in Cell and Developmental Biology, 2021 Cation channel of sperm (CatSper), the main sperm-specific Ca2+ channel, plays a key role in mammalian fertilization, and it is essential for male fertility, becoming an attractive target for contraception.
Ludmila Curci +4 more
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Frontiers in Endocrinology, 2020 Aim: Evidence suggests that bisphenol A diglycidyl ether (BADGE), bisphenol A (BPA), and BPA analogs can interfere with human male fertility. However, the effect directly on human sperm function is not known.
Anders Rehfeld +5 more
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The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm
Frontiers in Cell and Developmental Biology, 2023 The sperm-specific channel CatSper (cation channel of sperm) controls the intracellular Ca2+ concentration ([Ca2+]i) and plays an essential role in sperm function.
Lydia Wehrli +18 more
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Competitive CatSper Activators of Progesterone from Rhynchosia volubilis [PDF]
Planta Medica, 2021 AbstractThe root Rhynchosia volubilis was widely used for contraception in folk medicine, although its molecular mechanism on antifertility has not yet been revealed. In human sperm, it was reported that the cation channel of sperm, an indispensable cation channel for the fertilization process, could be regulated by various steroid-like compounds in ...
Xiang, Jin +13 more
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Study the role of KSper current for controlling the Ca2+ influx and intracellular pHi in mouse spermatozoa by dominating membrane potentials [PDF]
Iraqi Journal of Veterinary Sciences, 2022 This work was aimed to explore the details of the ion channels gating and there physiological role in sperm in the future.Mouse spermatozoa express a pH-dependent K+ current (KSper) thought to induce hyperpolarization to enhance Ca2+ influx via alkaline ...
Suha Alghazal
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