Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa [PDF]
Human Reproduction, 2016 Is diethylstilbestrol (DES), a prototypical endocrine-disrupting chemical (EDC), able to induce physiological changes in human spermatozoa and affect progesterone actions?DES promoted Ca2+ flux into human spermatozoa by activating the cation channel of sperm (CatSper) and suppressed progesterone-induced Ca2+ signaling, tyrosine phosphorylation and ...
Qianxing Zou +11 more
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EFCAB9 is a pH-Dependent Ca 2+ Sensor that Regulates CatSper Channel Activity and Sperm Motility [PDF]
Trends in Biochemical Sciences, 2018 The Ca2+-conducting ion channel, CatSper, is expressed exclusively on the sperm flagellum and regulates sperm motility. A new study (Hwang et al., Cell, 2019) reveals that the pH-sensing and Ca2+-binding protein, EFCAB9, is a subunit of the CatSper channel and has a key role in triggering mammalian sperm to change their swimming at fertilization.
Jae Yeon Hwang +7 more
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Intracellular domain of CATSPER1 could serve as a cytoplasmic platform for redox processes in mammalian sperm [PDF]
Animal BioscienceObjective Mammalian sperm acquire fertilizing ability in the female reproductive tract and develop hyperactivated motility, which is indispensable for male fertility. Hyperactivated motility is initiated by Ca2+ influx via the sperm-specific ion channel,
Jingon Kim, Jae Yeon Hwang
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Bicarbonate-Triggered In Vitro Capacitation of Boar Spermatozoa Conveys an Increased Relative Abundance of the Canonical Transient Receptor Potential Cation (TRPC) Channels 3, 4, 6 and 7 and of CatSper-γ Subunit mRNA Transcripts [PDF]
Animals, 2022 Sperm capacitation is a stepwise complex biochemical process towards fertilization. It includes a crucial early calcium (Ca2+) transport mediated by CatSper channels and Canonical Transient Potential Channels (TRPC).
Estíbaliz Lacalle +7 more
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Regulation of CatSper Channel through Non-Conventional Lipid Signaling [PDF]
Biophysical Journal, 2014 The sperm-specific cation channel, CatSper, regulates intracellular calcium levels and is crucial for male fertility, both in mice and humans. CatSper triggers hyperactivation, a type of inducible motility that enables sperm to penetrate the egg's protective vestments.
Melissa Miller +2 more
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Panax ginseng induces the expression of CatSper genes and sperm hyperactivation
Asian Journal of Andrology, 2014 The cation channel of sperm (CatSper) protein family plays important roles in male reproduction and infertility. The four members of this family are expressed exclusively in the testis and are localized differently in sperm. To investigate the effects of
Eun Hwa Park +4 more
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Effects of Resistance Training on Serum Inflammatory Markers and CatSper 1-4 Protein Expression in Testis of OLETF Rats [PDF]
운동과학, 2017 PURPOSE This study was to investigate the effects of resistance exercise on serum inflammatory markers and CatSper 1-4 expression in testis of OLETF rats.
Min-Ki Lee, Se-Hwan Park, Jin-Hwan Yoon
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Iranian Journal of Medical Sciences, 2018 Background: Low levels of reactive oxygen species (ROS) and calcium are necessary for sperm function. NADPH oxidase 5 (NOX5) is a membrane enzyme which produces ROS. This enzyme is dependent on calcium for its activity.
Hamideh Ghanbari +2 more
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Human fertilization in vivo and in vitro requires the CatSper channel to initiate sperm hyperactivation [PDF]
The Journal of Clinical InvestigationThe infertility of many couples rests on an enigmatic dysfunction of the man’s sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of almost 2,300 ...
Samuel Young +24 more
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Catspermasome: The matrimony of CatSper and SLCO6C1 [PDF]
Biophysical Journal, 2023 Jianping Wu
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