Results 1 to 10 of about 65,478 (114)

Energy Metabolism and Hyperactivation of Spermatozoa from Three Mouse Species under Capacitating Conditions

Cells, 2022
Mammalian sperm differ widely in sperm morphology, and several explanations have been presented to account for this diversity. Less is known about variation in sperm physiology and cellular processes that can give sperm cells an advantage when competing ...
Maximiliano Tourmente, Eduardo Roldan, Roldan Eduardo R S   +2 more
exaly   +3 more sources

Large cyclic AMP-dependent increases in tyrosine-phosphorylated proteins are not absolutely necessary for the induction of full-type hyperactivation and penetration into eggs in ejaculated boar spermatozoa in vitro [PDF]

The Journal of Reproduction and Development
Although it is well-known that sperm tyrosine-phosphorylated proteins increase in a cyclic AMP (cAMP)-dependent manner during capacitation, it remains unclear whether or not this reaction is involved directly in sperm fertilization-related events.
Ami UESHIBA, Riko NAKAO, Riho MORIKAWA-TOMITA, Hirohisa KYOGOKU, Hiroshi HARAYAMA   +4 more
doaj   +2 more sources

Serotonergic signals enhanced hamster sperm hyperactivation

Journal of Reproduction and Development, 2021
In the present study, we investigated the regulatory mechanisms underlying sperm hyperactivation enhanced by 5-hydroxytryptamine (5-HT) in hamsters. First, we examined the types of 5-HT receptors that regulate hyperactivation.
Satoshi Obayashi
exaly   +3 more sources

Capacitation-Induced Mitochondrial Activity Is Required for Sperm Fertilizing Ability in Mice by Modulating Hyperactivation

Frontiers in Cell and Developmental Biology, 2021
To become fully competent to fertilize an egg, mammalian sperm undergo a series of functional changes within the female tract, known as capacitation, that require an adequate supply and management of energy.
Vanina Gabriela Da Ros
exaly   +3 more sources

Palmitoyltransferase DHHC7 mediates protein palmitoylation and is essential for sperm function through the modulation of [Ca2+]i and ROS signaling [PDF]

Frontiers in Cell and Developmental Biology
BackgroundPalmitoylacyltransferase DHHC7 (DHHC7) plays a critical role in various biological processes and diseases. However, its expression, localization, and regulatory mechanisms in sperm function remain largely unknown.MethodsImmunofluorescent ...
Haixia Zheng, Haixia Zheng, Xiaohong Cheng, Xiaohong Cheng, Wenjie Hao, Wenjie Hao, Peibei Sun, Yamei Xue, Jincui Ye, Xiumei Jiang, Changzhao Jiang, Kun Li   +11 more
doaj   +2 more sources

Can adaptive hyperactivation result in a positive score on the Mood Disorder Questionnaire? Evidence from a case-control study over a community survey [PDF]

Frontiers in Psychiatry
BackgroundBipolar Disorder (BD) remains challenging to identify, and the Mood Disorder Questionnaire (MDQ) may capture heterogeneous forms of hyperactivation, including adaptive patterns unrelated to psychopathology.ObjectivesTo determine whether MDQ ...
Michela Atzeni, Michele Fornaro, Massimo Tusconi, Cesar Ivan Aviles Gonzalez, Elisa Cantone, Elisa Pintus, Serdar M. Dursun, Antonio E. Nardi, Federica Sancassiani, Mauro Giovanni Carta, Mauro Giovanni Carta, Mauro Giovanni Carta   +11 more
doaj   +2 more sources

Conserved Mechanism of Bicarbonate-Induced Sensitization of CatSper Channels in Human and Mouse Sperm

Frontiers in Cell and Developmental Biology, 2021
To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract. A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated by membrane depolarization and intracellular alkalinization.
Juan J. Ferreira, Juan J. Ferreira, Pascale Lybaert, Lis C. Puga-Molina, Celia M. Santi, Celia M. Santi   +5 more
doaj   +1 more source

KCNQ1 Potassium Channel Expressed in Human Sperm Is Involved in Sperm Motility, Acrosome Reaction, Protein Tyrosine Phosphorylation, and Ion Homeostasis During Capacitation

Frontiers in Physiology, 2021
Potassium channels are involved in membrane hyperpolarization and ion homeostasis regulation during human sperm capacitation. However, the types of potassium channels in human sperm remain controversial.
Tian Gao, Kun Li, Kun Li, Fei Liang, Fei Liang, Jianmin Yu, Jianmin Yu, Ajuan Liu, Ya Ni, Ya Ni, Peibei Sun, Peibei Sun   +11 more
doaj   +1 more source

Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling

Frontiers in Immunology, 2023
Inflammasomes are supramolecular platforms that organize in response to various damage-associated molecular patterns and pathogen-associated molecular patterns.
Yang Li, Qianzhou Jiang
doaj   +1 more source

A quadratic function of activation in individuals at risk of Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Brain activation is hypothesized to form an inverse U‐shape in prodromal Alzheimer's disease (AD), with hyperactivation in the early phase, followed by hypoactivation.
Nick Corriveau‐Lecavalier, Simon Duchesne, Serge Gauthier, Carol Hudon, Marie‐Jeanne Kergoat, Samira Mellah, Sylvie Belleville, for the Consortium for the Early Identification of Alzheimer's Disease‐Quebec (CIMA‐Q)   +7 more
doaj   +1 more source