Results 1 to 10 of about 97,911 (299)

Serotonergic signals enhanced hamster sperm hyperactivation

The Journal of Reproduction and Development, 2021
In the present study, we investigated the regulatory mechanisms underlying sperm hyperactivation enhanced by 5-hydroxytryptamine (5-HT) in hamsters. First, we examined the types of 5-HT receptors that regulate hyperactivation.
Chiyori SAKAMOTO, Masakatsu FUJINOKI, Masafumi KITAZAWA, Satoshi OBAYASHI   +3 more
doaj   +4 more sources

Energy Metabolism and Hyperactivation of Spermatozoa from Three Mouse Species under Capacitating Conditions

Cells, 2022
Mammalian sperm differ widely in sperm morphology, and several explanations have been presented to account for this diversity. Less is known about variation in sperm physiology and cellular processes that can give sperm cells an advantage when competing ...
Ester Sansegundo, Maximiliano Tourmente, Eduardo R. S. Roldan   +2 more
doaj   +3 more sources

Large cyclic AMP-dependent increases in tyrosine-phosphorylated proteins are not absolutely necessary for the induction of full-type hyperactivation and penetration into eggs in ejaculated boar spermatozoa in vitro [PDF]

The Journal of Reproduction and Development
Although it is well-known that sperm tyrosine-phosphorylated proteins increase in a cyclic AMP (cAMP)-dependent manner during capacitation, it remains unclear whether or not this reaction is involved directly in sperm fertilization-related events.
Ami UESHIBA, Riko NAKAO, Riho MORIKAWA-TOMITA, Hirohisa KYOGOKU, Hiroshi HARAYAMA   +4 more
doaj   +2 more sources

Can adaptive hyperactivation result in a positive score on the Mood Disorder Questionnaire? Evidence from a case-control study over a community survey [PDF]

Frontiers in Psychiatry
BackgroundBipolar Disorder (BD) remains challenging to identify, and the Mood Disorder Questionnaire (MDQ) may capture heterogeneous forms of hyperactivation, including adaptive patterns unrelated to psychopathology.ObjectivesTo determine whether MDQ ...
Michela Atzeni, Michele Fornaro, Massimo Tusconi, Cesar Ivan Aviles Gonzalez, Elisa Cantone, Elisa Pintus, Serdar M. Dursun, Antonio E. Nardi, Federica Sancassiani, Mauro Giovanni Carta, Mauro Giovanni Carta, Mauro Giovanni Carta   +11 more
doaj   +2 more sources

Tryptophan promotes sperm hyperactivation in hamsters via 5-hydroxytryptamine biosynthesis within sperm [PDF]

The Journal of Reproduction and Development
L-tryptophan (Trp), an essential amino acid, is a precursor of 5-hydroxytryptamine (5-HT; also known as serotonin) that promotes mammalian sperm hyperactivation.
Issei SUZUKI, Masakatsu FUJINOKI, Takao KAMAI   +2 more
doaj   +2 more sources

Dynamic dosage changes in X-linked transposable elements during mammalian dosage compensation [PDF]

Nature Communications
In mammals, X-linked dosage compensation involves X-chromosome inactivation to balance X chromosome dosage between males and females, and hyperactivation of the remaining X-chromosome (Xa-hyperactivation) to achieve X-autosome balance in both sexes ...
Chunyao Wei, Barry Kesner, Uri Weissbein, Peera Wasserzug-Pash, Priyojit Das, Jeannie T. Lee   +5 more
doaj   +2 more sources

Nucleotide metabolic rewiring enables NLRP3 inflammasome hyperactivation in obesity. [PDF]

Science
Liu D, Zhou C, Wang X, Luo Z, Xu R, Huo S, Guo L, Luo X, Yang S, Click A, Vancil J, Barajas P, Mijares V, Baniasadi H, Yan N, Rehwinkel J, Hancks DC, Chen EH, Liang S, Zhong Z.   +19 more
europepmc   +2 more sources

Conserved Mechanism of Bicarbonate-Induced Sensitization of CatSper Channels in Human and Mouse Sperm

Frontiers in Cell and Developmental Biology, 2021
To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract. A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated by membrane depolarization and intracellular alkalinization.
Juan J. Ferreira, Juan J. Ferreira, Pascale Lybaert, Lis C. Puga-Molina, Celia M. Santi, Celia M. Santi   +5 more
doaj   +1 more source

KCNQ1 Potassium Channel Expressed in Human Sperm Is Involved in Sperm Motility, Acrosome Reaction, Protein Tyrosine Phosphorylation, and Ion Homeostasis During Capacitation

Frontiers in Physiology, 2021
Potassium channels are involved in membrane hyperpolarization and ion homeostasis regulation during human sperm capacitation. However, the types of potassium channels in human sperm remain controversial.
Tian Gao, Kun Li, Kun Li, Fei Liang, Fei Liang, Jianmin Yu, Jianmin Yu, Ajuan Liu, Ya Ni, Ya Ni, Peibei Sun, Peibei Sun   +11 more
doaj   +1 more source

Capacitation-Induced Mitochondrial Activity Is Required for Sperm Fertilizing Ability in Mice by Modulating Hyperactivation

Frontiers in Cell and Developmental Biology, 2021
To become fully competent to fertilize an egg, mammalian sperm undergo a series of functional changes within the female tract, known as capacitation, that require an adequate supply and management of energy.
María Milagros Giaccagli, Matías Daniel Gómez-Elías, Jael Dafne Herzfeld, Clara Isabel Marín-Briggiler, Patricia Sara Cuasnicú, Débora Juana Cohen, Vanina Gabriela Da Ros   +6 more
doaj   +1 more source