Results 31 to 40 of about 9,958 (250)
TRPV4 is the temperature-sensitive ion channel of human sperm
eLife, 2018 Ion channels control the ability of human sperm to fertilize the egg by triggering hyperactivated motility, which is regulated by membrane potential, intracellular pH, and cytosolic calcium.
Nadine Mundt +2 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Mammalian sperm require sufficient energy to support motility and capacitation for successful fertilization. Previous studies cataloging the changes to metabolism in sperm explored ejaculated human sperm or dormant mouse sperm surgically extracted from ...
Melanie Balbach +8 more
doaj +1 more source
Hyperactivated endolysosomal trafficking in melanoma
Oncotarget, 2015 Cutaneous melanoma is an increasingly frequent solid tumor that accounts for 80% of skin cancer-related deaths. Characterized by a complex and heterogeneous genetic background and a notorious functional plasticity, melanoma has shifted from a “black box” to a paradigm of how basic research can be successfully translated into significant improvements of
Alonso-Curbelo, Direna, Soengas, MS
openaire +3 more sources
Amygdala hyperactivation in untreated depressed individuals [PDF]
Psychiatry Research: Neuroimaging, 2009 The amygdala participates in the detection and control of affective states, and has been proposed to be a site of dysfunction in affective disorders. To assess amygdala processing in individuals with unipolar depression, we applied a functional MRI (fMRI) paradigm previously shown to be sensitive to amygdala function.
Peluso, Marco A. M. +10 more
openaire +3 more sources
Molecules, 2021 In this work, the effect of different immobilization procedures on the properties of a lipase obtained from the extremophilic microorganism Serratia sp.
Mónica Ruiz +7 more
doaj +1 more source
The Chemosensing Role of CatSper in Mammalian Sperm: An Updated Review
Current Issues in Molecular Biology, 2023 After sperm enter the female reproductive tract, the physicochemical and biochemical microenvironment undergoes significant changes. In particular, the large changes in various ions encountered by sperm may alter the physiology of sperm, ultimately ...
Sulun Ke, Tao Luo
doaj +1 more source
Hyperactivation in human semen and sperm subpopulations by selected calcium modulators [PDF]
, 2014 Magister Scientiae (Medical Bioscience) - MSc(MBS)A functional sperm is critical for successful fertilization in order to deliver an intact genome to the site of fertilization. It is often characterized by high motility and normal morphology.
Ntanjana, Nomfundo
core +1 more source
Frontiers in Cell and Developmental Biology, 2021 Cation channel of sperm (CatSper), the main sperm-specific Ca2+ channel, plays a key role in mammalian fertilization, and it is essential for male fertility, becoming an attractive target for contraception.
Ludmila Curci +4 more
doaj +1 more source
PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation
, 2022 Summary: Vascular aging is an independent risk factor for cardiovascular diseases, but the regulatory mechanism is not clearly understood. In this study, we found that endothelial PKR activity is elevated in aging aorta tissues, which is accompanied with
Xiqing Tan +11 more
core +1 more source
P-REX1-Independent, Calcium-Dependent RAC1 Hyperactivation in Prostate Cancer [PDF]
, 2020 The GTPase Rac1 is a well-established master regulator of cell motility and invasiveness contributing to cancer metastasis. Dysregulation of the Rac1 signaling pathway, resulting in elevated motile and invasive potential, has been reported in multiple ...
Garcia-Mata, Rafael +7 more
core +1 more source