Results 31 to 40 of about 97,911 (299)
Diverse Control Mechanisms of the Interleukin-1 Cytokine Family
Frontiers in Cell and Developmental Biology, 2022 The majority of interleukin-1 (IL-1) family cytokines lack amino terminal secretion signals or transmembrane domains for secretion along the conventional biosynthetic pathway.
Charles L. Evavold, Jonathan C. Kagan
doaj +1 more source
Essential role of CFTR in PKA-dependent phosphorylation, alkalinization, and hyperpolarization during human dperm capacitation [PDF]
, 2017 Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation.
Austin +63 more
core +1 more source
Control of hyperactivation in sperm [PDF]
Human Reproduction Update, 2008 Sperm hyperactivation is critical to fertilization, because it is required for penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from the oviductal storage reservoir and may propel sperm through mucus in the oviductal lumen and the matrix of the cumulus oophorus.
openaire +2 more sources
TRPV4 is the temperature-sensitive ion channel of human sperm
eLife, 2018 Ion channels control the ability of human sperm to fertilize the egg by triggering hyperactivated motility, which is regulated by membrane potential, intracellular pH, and cytosolic calcium.
Nadine Mundt +2 more
doaj +1 more source
Hyperactivated endolysosomal trafficking in melanoma
Oncotarget, 2015 Cutaneous melanoma is an increasingly frequent solid tumor that accounts for 80% of skin cancer-related deaths. Characterized by a complex and heterogeneous genetic background and a notorious functional plasticity, melanoma has shifted from a “black box” to a paradigm of how basic research can be successfully translated into significant improvements of
Alonso-Curbelo, Direna, Soengas, MS
openaire +3 more sources
Effects of aging and oviductal hormones on testes, epididymides, and sperm of hamster
Reproductive Medicine and Biology, 2022 Purpose Aging is a major cause of decreased fertility. Using hamster, we examined the effects of aging on testes, epididymides, and sperm. Additionally, we examined whether progesterone (P4), melatonin (Mel) and 5‐hydroxytryptamine (5‐HT) mitigated ...
Manami Miyashita, Masakatsu Fujinoki
doaj +1 more source
Evidence of the presence of calcium/calmodulin-dependent protein kinase IV in human sperm and its involvement in motility regulation [PDF]
, 2005 The mechanisms involved in the regulation of mammalian sperm motility are not well understood. Calcium ions (Ca(2+)) have been suggested to play a key role in the maintenance of motility; nevertheless, how Ca(2+) modulates this process has not yet been ...
Buffone, Mariano Gabriel +6 more
core +1 more source
The Journal of Reproduction and Development, 2023 Progesterone (P) enhances spermatozoal hyperactivation, a capacitation event. Hyperactivation is associated with successful in vitro fertilization (IVF). In this study, we examined the effects of P on hyperactivation and IVF in mice.
Risa SUZUKI, Masakatsu FUJINOKI
doaj +1 more source
Notch and NF-kB: Coach and Players of Regulatory T-Cell Resposnse in Cancer [PDF]
, 2018 The Notch signaling pathway plays multiple roles in driving T-cell fate decisions, proliferation, and aberrant growth. NF-kB is a cell-context key player interconnected with Notch signaling either in physiological or in pathological conditions.
Bellavia, Diana +5 more
core +2 more sources
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy [PDF]
, 2009 Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively.
Baas, Dominique +27 more
core +5 more sources