Results 51 to 60 of about 9,958 (250)
Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease [PDF]
Annals of Neurology, 2010 AbstractObjectiveThe examination of individuals who carry fully penetrant genetic alterations that result in familial Alzheimer's disease (FAD) provides a unique model for studying the early presymptomatic disease stages. In AD, deficits in episodic and associative memory have been linked to structural and functional changes within the hippocampal ...
Quiroz, Yakeel T. +7 more
openaire +3 more sources
Mathematical modeling of calcium signaling during sperm hyperactivation [PDF]
, 2020 : Mammalian sperm must hyperactivate in order to fertilize oocytes. Hyperactivation is characterized by highly asymmetrical flagellar bending. It serves to move sperm out of the oviductal reservoir and to penetrate viscoelastic fluids, such as the ...
L J Fauci, S S Suarez, S D Olson
core
Journal of Integrative Agriculture, 2014 Hyperactivation is one of the most critical parts for fertilization. cAMP generated by soluble adenylyl cyclase (sAC) is necessary to activate sperm and is a prerequisite for sperm hyperactivation.
Jing YU +3 more
doaj +1 more source
Effects of aging and oviductal hormones on testes, epididymides, and sperm of hamster
Reproductive Medicine and Biology, 2022 Purpose Aging is a major cause of decreased fertility. Using hamster, we examined the effects of aging on testes, epididymides, and sperm. Additionally, we examined whether progesterone (P4), melatonin (Mel) and 5‐hydroxytryptamine (5‐HT) mitigated ...
Manami Miyashita, Masakatsu Fujinoki
doaj +1 more source
Molecular mechanism of hyperactivation conferred by a truncation of TRPA1
Nature Communications, 2023 AbstractA drastic TRPA1 mutant (R919*) identified in CRAMPT syndrome patients has not been mechanistically characterized. Here, we show that the R919* mutant confers hyperactivity when co-expressed with wild type (WT) TRPA1. Using functional and biochemical assays, we reveal that the R919* mutant co-assembles with WT TRPA1 subunits into heteromeric ...
Avnika Bali +5 more
openaire +3 more sources
Suppression of progesterone-enhanced hyperactivation in hamster spermatozoa by estrogen
, 2010 In this study, I examined whether sperm hyperactivation in hamster is regulated by steroid hormones such as estrogen (estradiol, E2) and progesterone.
Masakatsu Fujinoki
core +1 more source
Collicular Hyperactivation in Patients with COVID-19: A New Finding on Brain MRI and PET/CT
, 2021 Hyperactivation of the colliculi has been observed in some patients with coronavirus disease ...
Brisset, J.-C. +13 more
core +1 more source
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Mst1-Deficiency Induces Hyperactivation of Monocyte-Derived Dendritic Cells via Akt1/c-myc Pathway
Frontiers in Immunology, 2019 Mst1 is a multifunctional serine/threonine kinase that is highly expressed in several immune organs. The role of Mst1 in the activation of dendritic cells (DCs), a key player of adaptive immunity, is poorly understood.
Kyung-Min Cho +4 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source