Results 61 to 70 of about 9,958 (250)

Defective HIV proviruses: possible involvement in the HIV infection pathogenesis

Вопросы вирусологии
This review article analyzes information obtained from a literature search on defective HIV genomes (HIV-1, Human Immunodeficiency Virus, Lentivirus, Orthoretrovirinae, Retroviridae). It discusses the origins of defective HIV genomes, their potential for
Marina R. Bobkova
doaj   +1 more source

Comparative characteristics between calyculin A-induced and thimerosal-induced hyperactivation of cryopreserved bovine spermatozoa

The Journal of Reproduction and Development, 2023
This study aimed to characterize calyculin A (CL-A)-induced and thimerosal-induced hyperactivation of cryopreserved bovine spermatozoa. Hyperactivation was effectively induced by treating with 10 nM CL-A for 60 min in the presence of cyclic AMP analogs ...
Natsuko MIYAMOTO, Akihiro OHYA, DURITAHALA, Mitsuhiro SAKASE, Hiroshi HARAYAMA   +4 more
doaj   +1 more source

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency [PDF]

, 2022
Haploinsufficiency of the progranulin (PGRN)-encoding gene (GRN) causes frontotemporal lobar degeneration (GRN-FTLD) and results in microglial hyperactivation, TREM2 activation, lysosomal dysfunction, and TDP-43 deposition. To understand the contribution
Bürger, Katharina, Dominik Paquet, Lengerich, Bettina van, Diehl-Schmid, Janine, Gilbert Di Paolo, Riedl, Lina, Steffanie Heindl, Robinson, Sophie, Sophie Haberl, Christian Haass, Sophie Robinson, Zatcepin, Artem, Haberl, Sophie, Julia K Götzl, Joseph W Lewcock, Paquet, Dominik, Levin, Johannes, Julien Klimmt, Nuscher, Brigitte, Jung Suh, Heindl, Steffanie, Katharina Bürger, Pesaemaa, Ida, Brigitte Nuscher, Gnörich, Johannes, Monroe, Kathryn M., Bettina van Lengerich, Klimmt, Julien, Johannes Levin, Reifschneider, Anika, Karin Wind, Endy Weidinger, Johannes Gnörich, Kleinberger, Gernot, Ida Pesämaa, Lina Riedl, Di Paolo, Gilbert, Miriam A Vogt, Götzl, Julia K., Kathryn M Monroe, Weidinger, Endy, Lewcock, Joseph W., Liesz, Arthur, Anja Capell, Arthur Liesz, Suh, Jung, Janine Diehl‐Schmid, Logan, Todd, Haass, Christian, Brendel, Matthias, Todd Logan, Artem Zatcepin, Matthias Brendel, Gernot Kleinberger, Vogt, Miriam A., Wind, Karin, Capell, Anja, Anika Reifschneider   +57 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Model of PARP-1 hyperactivation and recruitment of NHEJ proteins.

, 2012
Model of PARP-1 hyperactivation and recruitment of NHEJ proteins.
Natalie R. Gassman (126331), Samuel H. Wilson (14470), Donna F. Stefanick (126334), Padmini S. Kedar (126338), Julie K. Horton (126342)   +4 more
core   +1 more source

Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo [PDF]

Genes to Cells, 2018
Keap1 is a negative regulator of Nrf2, a master transcription factor that regulates cytoprotection against oxidative and electrophilic stresses. Although several studies have suggested that the Keap1‐Nrf2 system contributes to bone formation besides the maintenance of redox homeostasis, how Nrf2 hyperactivation by Keap1 deficiency affects the bone ...
Eiki Yoshida, Takafumi Suzuki, Masanobu Morita, Keiko Taguchi, Kohei Tsuchida, Hozumi Motohashi, Minoru Doita, Masayuki Yamamoto   +7 more
openaire   +2 more sources

3D‐Printed Piezoionic/Bioelectronic Hydrogel for Electro‐Metabolic Regulation of Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
A 3D‐printed piezoionic GPMx hydrogel enables stable electromechanical signal generation under mechanical loading, exhibiting long‐term durability and low fatigue. As a bioactive patch, it restores endogenous bioelectricity to stimulate osteogenesis via Ca2+ influx and mitochondrial activation, while simultaneously enabling label‐free alkaline ...
Sayan Deb Dutta, Myoung Joon Jeon, Youjin Seol, Ki‐Taek Lim   +3 more
wiley   +1 more source

Regulation of hamster sperm hyperactivation by extracellular Na+ [PDF]

Reproduction, 2016
Abstract Mammalian sperm motility has to be hyperactivated to be fertilization-competent. Hyperactivation is regulated by extracellular environment. Osmolality of mammalian semen is higher than that in female reproductive tract; however, the effect of them on hyperactivation has not been investigated.
Gen L, Takei, Masakatsu, Fujinoki
openaire   +2 more sources

A vicious cycle of β amyloid-dependent neuronal hyperactivation [PDF]

, 2019
beta-amyloid (A beta)-dependent neuronal hyperactivity is believed to contribute to the circuit dysfunction that characterizes the early stages of Alzheimer's disease (AD). Although experimental evidence in support of this hypothesis continues to accrue,
Sakmann, Bert, Simon, Manuel M., Frosch, Matthew P., Konnerth, Arthur, Unger, Felix, Hong, Wei, Walsh, Dominic M., Zott, Benedikt, Chen-Engerer, Hsing-Jung   +8 more
core   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source