Results 61 to 70 of about 97,911 (299)

Ras hyperactivation versus overexpression : Lessons from Ras dynamics in Candida albicans [PDF]

, 2018
We thank Prof. Neta Dean for the CIp10ADH1-Cherry plasmid and Prof. Aaron Mitchell for the BWP17 strain. We gratefully acknowledge Prof. Sudipta Maiti, TIFR, Mumbai, India for providing the data acquisition software.
Haokip, Dominic T, Jain, Priyanka, Khan, Mohammad Firoz, Komath, Sneha Sudha, Pal, Nibedita, Pratyusha, Vavilala A, Sen, Sobhan, Sethi, Subhash Chandra, Singh, Sneh Lata, Victoria, Guiliana Soraya, Yadav, Bhawna   +10 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Neural Dedifferentiation in Relation to Risk for Alzheimer\u27s Disease [PDF]

, 2010
Functional magnetic resonance imaging (fMRI) research indicates that as an individual\u27s age increases, the task-related spatial extent of neural activation increases.
Hantke, Nathan C.
core   +1 more source

Comparative characteristics between calyculin A-induced and thimerosal-induced hyperactivation of cryopreserved bovine spermatozoa

The Journal of Reproduction and Development, 2023
This study aimed to characterize calyculin A (CL-A)-induced and thimerosal-induced hyperactivation of cryopreserved bovine spermatozoa. Hyperactivation was effectively induced by treating with 10 nM CL-A for 60 min in the presence of cyclic AMP analogs ...
Natsuko MIYAMOTO, Akihiro OHYA, DURITAHALA, Mitsuhiro SAKASE, Hiroshi HARAYAMA   +4 more
doaj   +1 more source

Intestinal stem cell proliferation and epithelial homeostasis in the adult Drosophila midgut [PDF]

, 2015
Adult tissue homeostasis requires a tight balance between the removal of old or damaged cells and the production of new ones. Such processes are usually driven by dedicated stem cells that reside within specific tissue locations or niches.
Carroll, Lynsey, Cordero, Julia, Naszai, Mate   +2 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Defective HIV proviruses: possible involvement in the HIV infection pathogenesis

Вопросы вирусологии
This review article analyzes information obtained from a literature search on defective HIV genomes (HIV-1, Human Immunodeficiency Virus, Lentivirus, Orthoretrovirinae, Retroviridae). It discusses the origins of defective HIV genomes, their potential for
Marina R. Bobkova
doaj   +1 more source

Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity

Cell Reports, 2020
Summary: Central to anti-tumor immunity are dendritic cells (DCs), which stimulate long-lived protective T cell responses. Recent studies have demonstrated that DCs can achieve a state of hyperactivation, which is associated with inflammasome activities ...
Dania Zhivaki, Francesco Borriello, Ohn A. Chow, Benjamin Doran, Ira Fleming, Derek J. Theisen, Paris Pallis, Alex K. Shalek, Caroline L. Sokol, Ivan Zanoni, Jonathan C. Kagan   +10 more
doaj   +1 more source

Caveolin-1 deficiency induces a MEK-ERK1/2-Snail-1-dependent epithelial-mesenchymal transition and fibrosis during peritoneal dialysis [PDF]

, 2015
Peritoneal dialysis (PD) is a form of renal replacement therapy whose repeated use can alter dialytic function through induction of epithelial-mesenchymal transition (EMT) and fibrosis, eventually leading to PD discontinuation. The peritoneum from Cav1-/-
Enrique, Calvo, Ignacio, Benedicto, Jesús, Loureiro, Jesús, Vázquez, Manuel López, Cabrera, Maria Teresa, Osteso, María Luisa Pérez, Lozano, Miguel Angel del, Pozo, Miguel, Foronda, Olga, Barreiro, Strippoli, Raffaele, Susana, Minguet, Teijo, Pellinen, Vanessa, Moreno   +13 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source