Results 81 to 90 of about 97,911 (299)

Autophagy and rheumatoid arthritis: Current knowledges and future perspectives [PDF]

, 2018
Autophagy is a degradation mechanism by which cells recycle cytoplasmic components to generate energy. By influencing lymphocyte development, survival, and proliferation, autophagy regulates the immune responses against self and non-self antigens ...
Alessandri, Cristiano, Barbati, Cristiana, Ceccarelli, Fulvia, Colasanti, Tania, Conti, Fabrizio, Franco, Manuela Di, Novelli, Lucia, Perricone, Carlo, Spinelli, Francesca Romana, Valesini, Guido, Vomero, Marta   +10 more
core   +2 more sources

Hyperactivation et bouffées de chaleur

Psycause : revue scientifique étudiante de l'École de psychologie de l'Université Laval, 2019
Cette étude s’intéresse à l’implication de l’hyperactivation cognitive et somatique et des bouffées de chaleur dans l’insomnie pendant la transition ménopausique. La présente étude inclut 12 femmes (50,75 ± 9,30 ans) en périménopause ou en début de postménopause souffrant d’insomnie.
Johnathan Crépeau, Sarah Dussault, Mireille Lampron, Orlane Ballot, Charles M. Morin   +4 more
openaire   +2 more sources

Mathematical modeling of calcium signaling during sperm hyperactivation [PDF]

Molecular Human Reproduction, 2011
Mammalian sperm must hyperactivate in order to fertilize oocytes. Hyperactivation is characterized by highly asymmetrical flagellar bending. It serves to move sperm out of the oviductal reservoir and to penetrate viscoelastic fluids, such as the cumulus matrix. It is absolutely required for sperm penetration of the oocyte zona pellucida.
S D, Olson, L J, Fauci, S S, Suarez
openaire   +2 more sources

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

Fertilizing ability of spermatozoa: its conditioning factors and methods of determination (review)

Аграрная наука Евро-Северо-Востока
Fertilization is a complex process that results in the fusion of gametes. In order to obtain fertilizing ability, spermatozoa need to undergo post-ejaculation processes in the female reproductive tract.
T. Y. Berelet, E. A. Korochkina
doaj   +1 more source

PKR deficiency delays vascular aging via inhibiting GSDMD-mediated endothelial cell hyperactivation

iScience, 2023
Summary: Vascular aging is an independent risk factor for cardiovascular diseases, but the regulatory mechanism is not clearly understood. In this study, we found that endothelial PKR activity is elevated in aging aorta tissues, which is accompanied with
Zhouyangfan Peng, Xiqing Tan, Liangpeng Xie, Ze Li, Sufang Zhou, Yapei Li   +5 more
doaj   +1 more source

Regulation of hamster sperm hyperactivation by extracellular Na+ [PDF]

Reproduction, 2016
AbstractMammalian sperm motility has to be hyperactivated to be fertilization-competent. Hyperactivation is regulated by extracellular environment. Osmolality of mammalian semen is higher than that in female reproductive tract; however, the effect of them on hyperactivation has not been investigated. So we investigated the effect of osmotic environment
Gen L, Takei, Masakatsu, Fujinoki
openaire   +2 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

RNA Interference-Mediated Downregulation of sAC Gene Inhibits Sperm Hyperactivation in Male Rats (Rattus norvegicus)

Journal of Integrative Agriculture, 2014
Hyperactivation is one of the most critical parts for fertilization. cAMP generated by soluble adenylyl cyclase (sAC) is necessary to activate sperm and is a prerequisite for sperm hyperactivation.
Jing YU, Xiao-qiang JIANG, Shuai ZHOU, Gen-lin WANG   +3 more
doaj   +1 more source

Intranasal rapamycin ameliorates Alzheimer-like cognitive decline in a mouse model of Down syndrome [PDF]

, 2018
Background: Down syndrome (DS) individuals, by the age of 40s, are at increased risk to develop Alzheimer-like dementia, with deposition in brain of senile plaques and neurofibrillary tangles.
Arena, Andrea, Barone, Eugenio, Blarzino, Carla, Butterfield, D. Allan, Di Domenico, Fabio, Lanzillotta, Chiara, Mosca, Luciana, Perluigi, Marzia, Tramutola, Antonella, Zuliani, Ilaria   +9 more
core   +3 more sources