Results 41 to 50 of about 9,958 (250)

Molecular Basis of Human Sperm Capacitation

Frontiers in Cell and Developmental Biology, 2018
In the early 1950s, Austin and Chang independently described the changes that are required for the sperm to fertilize oocytes in vivo. These changes were originally grouped under name of “capacitation” and were the first step in the development of in ...
Lis C. Puga Molina, Guillermina M. Luque, Paula A. Balestrini, Clara I. Marín-Briggiler, Ana Romarowski, Mariano G. Buffone   +5 more
doaj   +1 more source

Progesterone significantly enhances the mobility of boar spermatozoa [PDF]

BioDiscovery, 2013
Progesterone released from the cumulus cells of the oocyte causes a number of physiological responses in human sperm cells including hyperactivation, acrosome reaction and chemotaxis. We employed a validated sperm mobility assay, which involves measuring
Johan M. Campbell, Anne L. Savage, Oladipo Madamidola, Kshitij Tamhane, Renalyn Soriano, Ashok K. Adya, Sean G. Brown   +6 more
doaj   +3 more sources

Signaling Enzymes Required for Sperm Maturation and Fertilization in Mammals

Frontiers in Cell and Developmental Biology, 2019
In mammals, motility and fertilizing ability of spermatozoa develop during their passage through the epididymis. After ejaculation, sperm undergo capacitation and hyperactivation in the female reproductive tract – a motility transition that is required ...
Souvik Dey, Cameron Brothag, Srinivasan Vijayaraghavan   +2 more
doaj   +1 more source

Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity

Cell Reports, 2020
Summary: Central to anti-tumor immunity are dendritic cells (DCs), which stimulate long-lived protective T cell responses. Recent studies have demonstrated that DCs can achieve a state of hyperactivation, which is associated with inflammasome activities ...
Dania Zhivaki, Francesco Borriello, Ohn A. Chow, Benjamin Doran, Ira Fleming, Derek J. Theisen, Paris Pallis, Alex K. Shalek, Caroline L. Sokol, Ivan Zanoni, Jonathan C. Kagan   +10 more
doaj   +1 more source

In vivo characterization of sAC null sperm

Frontiers in Cell and Developmental Biology, 2023
Targeted disruption of the soluble adenylyl cyclase (ADCY10; sAC) gene results in male-specific sterility without affecting spermatogenesis, mating behavior, or spermatozoa morphology and count; however, it dramatically impairs sperm motility and ...
Carla Ritagliati, Sylvia Ayoub, Melanie Balbach, Jochen Buck, Lonny R. Levin   +4 more
doaj   +1 more source

Modulatory effect of MG-132 proteasomal inhibition on boar sperm motility during in vitro capacitation

Frontiers in Veterinary Science, 2023
A series of biochemical and biophysical changes during sperm capacitation initiates various signaling pathways related to protein phosphorylation leading to sperm hyperactivation, simultaneously with the regulation of proteasomal activity responsible for
Lenka Hackerova, Barbora Klusackova, Michal Zigo, Natalie Zelenkova, Katerina Havlikova, Romana Krejcirova, Marketa Sedmikova, Peter Sutovsky, Peter Sutovsky, Katerina Komrskova, Katerina Komrskova, Pavla Postlerova, Pavla Postlerova, Ondrej Simonik   +13 more
doaj   +1 more source

Activation of sperm Toll-like receptor 2 induces hyperactivation to enhance the penetration to mucus and uterine glands: a trigger for the uterine inflammatory cascade in cattle

Frontiers in Immunology, 2023
It is known that sperm and seminal plasma (SP) affect uterine immunity. In cattle, artificial insemination enables breeding by depositing frozen and largely diluted sperm with a negligible amount of SP into the uterus.
Ihshan Akthar, Yejin Kim, Takashi Umehara, Chihiro Kanno, Motoki Sasaki, Mohamed Ali Marey, Mohamed Ali Marey, Mohamed Samy Yousef, Mohamed Samy Yousef, Shingo Haneda, Masayuki Shimada, Akio Miyamoto   +11 more
doaj   +1 more source

Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death

Journal of Lipid Research
Sterol-regulatory element binding proteins (SREBPs) are a conserved transcription factor family governing lipid metabolism. When cellular cholesterol level is low, SREBP2 is transported from the endoplasmic reticulum to the Golgi apparatus where it ...
Yanni Xiong, Jie Luo, Zi-Yun Hong, Wen-Zhuo Zhu, Ao Hu, Bao-Liang Song   +5 more
doaj   +1 more source

Diverse Control Mechanisms of the Interleukin-1 Cytokine Family

Frontiers in Cell and Developmental Biology, 2022
The majority of interleukin-1 (IL-1) family cytokines lack amino terminal secretion signals or transmembrane domains for secretion along the conventional biosynthetic pathway.
Charles L. Evavold, Jonathan C. Kagan
doaj   +1 more source

Melatonin-enhanced hyperactivation of hamster sperm [PDF]

Reproduction, 2008
Abstract The effects of melatonin on reproductive function were examined using hamster spermatozoa. When 1 pM to 1 μM melatonin was added to the mTALP medium, hyperactivation was significantly enhanced. Antagonists and agonists of the melatonin receptor (i.e., MT1 and MT2) were added to the medium.
openaire   +2 more sources