Results 41 to 50 of about 97,911 (299)

A novel germline hyperactivating JAK2 mutation L604F

Annals of Hematology, 2023
AbstractSomatic JAK2 mutations are the main molecular cause of the vast majority of polycythemia vera (PV) cases. According to a recent structural model, the prevalent acquired V617F mutation improves the stability of the JAK2 dimer, thereby enhancing the constitutive JAK2 kinase activity.
Lukáš Dvořáček, Jana Marková, Aleš Holoubek, Dana Grebeňová, David Kundrát, Kateřina Kuželová, Jiří Schwarz   +6 more
openaire   +2 more sources

Molecular Basis of Human Sperm Capacitation

Frontiers in Cell and Developmental Biology, 2018
In the early 1950s, Austin and Chang independently described the changes that are required for the sperm to fertilize oocytes in vivo. These changes were originally grouped under name of “capacitation” and were the first step in the development of in ...
Lis C. Puga Molina, Guillermina M. Luque, Paula A. Balestrini, Clara I. Marín-Briggiler, Ana Romarowski, Mariano G. Buffone   +5 more
doaj   +1 more source

Targeting STAT3 in Cancer with Nucleotide Therapeutics. [PDF]

, 2019
Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for ...
Grandis, Jennifer R, Johnson, Daniel E, Lau, Yue-Ting K, Ramaiyer, Malini   +3 more
core   +2 more sources

Melatonin-enhanced hyperactivation of hamster sperm [PDF]

REPRODUCTION, 2008
The effects of melatonin on reproductive function were examined using hamster spermatozoa. When 1 pM to 1 μM melatonin was added to the mTALP medium, hyperactivation was significantly enhanced. Antagonists and agonists of the melatonin receptor (i.e., MT1 and MT2) were added to the medium. Luzindole, an MT1 and MT2 competitive antagonist, significantly
openaire   +2 more sources

Signaling Enzymes Required for Sperm Maturation and Fertilization in Mammals

Frontiers in Cell and Developmental Biology, 2019
In mammals, motility and fertilizing ability of spermatozoa develop during their passage through the epididymis. After ejaculation, sperm undergo capacitation and hyperactivation in the female reproductive tract – a motility transition that is required ...
Souvik Dey, Cameron Brothag, Srinivasan Vijayaraghavan   +2 more
doaj   +1 more source

Human sperm ion channel (dys)function:implications for fertilization [PDF]

, 2019
BACKGROUND: Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Barratt, Christopher L. R., Brown, Sean G., Martins da Silva, Sarah J., Publicover, Stephen J.   +3 more
core   +4 more sources

Hyperactivation of mammalian spermatozoa: function and regulation [PDF]

Reproduction, 2001
Hyperactivation is a movement pattern observed in spermatozoa at the site and time of fertilization in mammals. It may be critical to the success of fertilization, because it enhances the ability of spermatozoa to detach from the wall of the oviduct, to move around in the labyrinthine lumen of the oviduct, to penetrate mucous substances and, finally ...
H C, Ho, S S, Suarez
openaire   +2 more sources

Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm. [PDF]

, 2019
The Notch signaling pathway contributes to the pathogenesis of a wide spectrum of human cancers, including hematopoietic malignancies. Its functions are highly dependent on the specific cellular context. Gain-of-function NOTCH1 mutations are prevalent in
Chang, Yuan-I, Hofmann, Inga, Kong, Guangyao, Letson, Christopher, Liu, Yangang, Loh, Mignon, Padron, Eric, Pear, Warren S, Qian, Shuiming, Rajagopalan, Adhithi, Ranheim, Erik A, Stieglitz, Elliot, Wen, Zhi, Yang, David, You, Xiaona, Zhang, Jing, Zhang, Jingfang, Zhang, Xinmin, Zhong, Xuehua, Zhou, Lan, Zhou, Yun   +20 more
core   +1 more source

Hippocampal hyperactivation in presymptomatic familial Alzheimer's disease [PDF]

Annals of Neurology, 2010
AbstractObjectiveThe examination of individuals who carry fully penetrant genetic alterations that result in familial Alzheimer's disease (FAD) provides a unique model for studying the early presymptomatic disease stages. In AD, deficits in episodic and associative memory have been linked to structural and functional changes within the hippocampal ...
Yakeel T, Quiroz, Andrew E, Budson, Kim, Celone, Adriana, Ruiz, Randall, Newmark, Gabriel, Castrillón, Francisco, Lopera, Chantal E, Stern   +7 more
openaire   +2 more sources

Single-cell analysis of [Ca²⁺]i signalling in sub-fertile men:characteristics and relation to fertilization outcome [PDF]

, 2018
STUDY QUESTIONWhat are the characteristics of progesterone-induced (CatSper-mediated) single cell [Ca2+]i signals in spermatozoa from sub-fertile men and how do they relate to fertilizing ability?SUMMARY ANSWERSingle cell analysis of progesterone-induced
Barratt, Christopher L.R., Brown, Sean G., Costello, Sarah M., Drew, Ellen, Kelly, Mark C., Martins da Silva, Sarah, Publicover, Stephen J., Ramalingam, Mythili   +7 more
core   +4 more sources