Results 21 to 30 of about 97,911 (299)
Frontiers in Cell and Developmental Biology, 2021 Cation channel of sperm (CatSper), the main sperm-specific Ca2+ channel, plays a key role in mammalian fertilization, and it is essential for male fertility, becoming an attractive target for contraception.
Ludmila Curci +4 more
doaj +1 more source
In vivo characterization of sAC null sperm
Frontiers in Cell and Developmental Biology, 2023 Targeted disruption of the soluble adenylyl cyclase (ADCY10; sAC) gene results in male-specific sterility without affecting spermatogenesis, mating behavior, or spermatozoa morphology and count; however, it dramatically impairs sperm motility and ...
Carla Ritagliati +4 more
doaj +1 more source
New Approaches to Define The Functional Competency of Human Sperm Subpopulations and Its Relationship to Semen Quality [PDF]
International Journal of Fertility and Sterility, 2022 Background: This study aimed at comparing a comprehensive set of functional and structural sperm characteristics betweensperm motility fractions and correlating results to the standard semen parameters.
Shannen Keyer +2 more
doaj +1 more source
Amygdala hyperactivation in untreated depressed individuals [PDF]
Psychiatry Research: Neuroimaging, 2009 The amygdala participates in the detection and control of affective states, and has been proposed to be a site of dysfunction in affective disorders. To assess amygdala processing in individuals with unipolar depression, we applied a functional MRI (fMRI) paradigm previously shown to be sensitive to amygdala function.
Peluso, Marco A. M. +10 more
openaire +3 more sources
Frontiers in Veterinary Science, 2023 A series of biochemical and biophysical changes during sperm capacitation initiates various signaling pathways related to protein phosphorylation leading to sperm hyperactivation, simultaneously with the regulation of proteasomal activity responsible for
Lenka Hackerova +13 more
doaj +1 more source
fMRI evidence that precision ophthalmic tints reduce cortical hyperactivation in migraine [PDF]
, 2011 Background: Certain patterns can induce perceptual illusions/distortions and visual discomfort in most people, headaches in patients with migraine, and seizures in patients with photosensitive epilepsy.
Bozoki, Andrea +5 more
core +1 more source
Frontiers in Immunology, 2023 It is known that sperm and seminal plasma (SP) affect uterine immunity. In cattle, artificial insemination enables breeding by depositing frozen and largely diluted sperm with a negligible amount of SP into the uterus.
Ihshan Akthar +11 more
doaj +1 more source
Stress hypERactivation in the β-cell [PDF]
Islets, 2010 In pancreatic β-cells, the endoplasmic reticulum (ER) is the crucial site for insulin biosynthesis, as this is where the protein-folding machinery for secretory proteins is localized. Perturbations to ER function of the β-cell, such as a high demand for insulin secretion, can lead to an imbalance in protein homeostasis and lead to ER stress.
Fonseca, Sonya G. +3 more
openaire +3 more sources
Frontiers in Cellular Neuroscience, 2014 The hippocampus is one of the earliest affected brain regions in Alzheimer´s disease (AD) and its dysfunction is believed to underlie the core feature of the disease- memory impairment.
Aleksandra eMaruszak, Sandrine eThuret
doaj +1 more source
Signalling by senescent melanocytes hyperactivates hair growth
Nature, 2023 AbstractNiche signals maintain stem cells in a prolonged quiescence or transiently activate them for proper regeneration1. Altering balanced niche signalling can lead to regenerative disorders. Melanocytic skin nevi in human often display excessive hair growth, suggesting hair stem cell hyperactivity.
Xiaojie Wang +49 more
openaire +6 more sources