Results 21 to 30 of about 65,627 (261)

Activation of sperm Toll-like receptor 2 induces hyperactivation to enhance the penetration to mucus and uterine glands: a trigger for the uterine inflammatory cascade in cattle

open access: yesFrontiers in Immunology, 2023
It is known that sperm and seminal plasma (SP) affect uterine immunity. In cattle, artificial insemination enables breeding by depositing frozen and largely diluted sperm with a negligible amount of SP into the uterus.
Ihshan Akthar   +11 more
doaj   +1 more source

Control of hyperactivation in sperm [PDF]

open access: yesHuman Reproduction Update, 2008
Sperm hyperactivation is critical to fertilization, because it is required for penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from the oviductal storage reservoir and may propel sperm through mucus in the oviductal lumen and the matrix of the cumulus oophorus.
openaire   +2 more sources

Regulation of hyperactivation by PPP2 in hamster spermatozoa [PDF]

open access: yesReproduction, 2010
Abstract It has been widely accepted that serine/threonine protein phosphatases (PPPs) are associated with the regulation of sperm hyperactivation. In the present study, we examined the types of PPPs associated with the regulation of hamster sperm hyperactivation.
Tatsuya, Suzuki   +3 more
openaire   +2 more sources

Why looking at the whole hippocampus is not enough – a critical role for anteroposterior axis, subfield and activation analyses to enhance predictive value of hippocampal changes for Alzheimer’s disease diagnosis.

open access: yesFrontiers in Cellular Neuroscience, 2014
The hippocampus is one of the earliest affected brain regions in Alzheimer´s disease (AD) and its dysfunction is believed to underlie the core feature of the disease- memory impairment.
Aleksandra eMaruszak, Sandrine eThuret
doaj   +1 more source

Diverse Control Mechanisms of the Interleukin-1 Cytokine Family

open access: yesFrontiers in Cell and Developmental Biology, 2022
The majority of interleukin-1 (IL-1) family cytokines lack amino terminal secretion signals or transmembrane domains for secretion along the conventional biosynthetic pathway.
Charles L. Evavold, Jonathan C. Kagan
doaj   +1 more source

TRPV4 is the temperature-sensitive ion channel of human sperm

open access: yeseLife, 2018
Ion channels control the ability of human sperm to fertilize the egg by triggering hyperactivated motility, which is regulated by membrane potential, intracellular pH, and cytosolic calcium.
Nadine Mundt   +2 more
doaj   +1 more source

Effects of aging and oviductal hormones on testes, epididymides, and sperm of hamster

open access: yesReproductive Medicine and Biology, 2022
Purpose Aging is a major cause of decreased fertility. Using hamster, we examined the effects of aging on testes, epididymides, and sperm. Additionally, we examined whether progesterone (P4), melatonin (Mel) and 5‐hydroxytryptamine (5‐HT) mitigated ...
Manami Miyashita, Masakatsu Fujinoki
doaj   +1 more source

Hyperactivated endolysosomal trafficking in melanoma

open access: yesOncotarget, 2015
Cutaneous melanoma is an increasingly frequent solid tumor that accounts for 80% of skin cancer-related deaths. Characterized by a complex and heterogeneous genetic background and a notorious functional plasticity, melanoma has shifted from a “black box” to a paradigm of how basic research can be successfully translated into significant improvements of
Alonso-Curbelo, Direna, Soengas, MS
openaire   +3 more sources

Regulation of hyperactivation of hamster spermatozoa by progesterone [PDF]

open access: yesReproductive Medicine and Biology, 2008
Aim:  Although it is accepted that progesterone (P) induces acrosome reaction through non‐genomic regulation, it is not well known if P also affects hyperactivation of sperm.Methods:  Hamster spermatozoa were hyperactivated by incubation for 4 h on modified Tyrode's albumin lactate pyruvate medium and recorded on a DVD via a charge‐coupled device ...
Takao, Noguchi   +3 more
openaire   +2 more sources

Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice

open access: yesThe Journal of Reproduction and Development, 2023
Progesterone (P) enhances spermatozoal hyperactivation, a capacitation event. Hyperactivation is associated with successful in vitro fertilization (IVF). In this study, we examined the effects of P on hyperactivation and IVF in mice.
Risa SUZUKI, Masakatsu FUJINOKI
doaj   +1 more source

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