Results 21 to 30 of about 9,958 (250)

Uncoupled pyroptosis and IL-1β secretion downstream of inflammasome signaling

Frontiers in Immunology, 2023
Inflammasomes are supramolecular platforms that organize in response to various damage-associated molecular patterns and pathogen-associated molecular patterns.
Yang Li, Qianzhou Jiang
doaj   +1 more source

A quadratic function of activation in individuals at risk of Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction Brain activation is hypothesized to form an inverse U‐shape in prodromal Alzheimer's disease (AD), with hyperactivation in the early phase, followed by hypoactivation.
Nick Corriveau‐Lecavalier, Simon Duchesne, Serge Gauthier, Carol Hudon, Marie‐Jeanne Kergoat, Samira Mellah, Sylvie Belleville, for the Consortium for the Early Identification of Alzheimer's Disease‐Quebec (CIMA‐Q)   +7 more
doaj   +1 more source

Hyperactivation of mammalian spermatozoa: function and regulation [PDF]

Reproduction, 2001
Abstract Hyperactivation is a movement pattern observed in spermatozoa at the site and time of fertilization in mammals. It may be critical to the success of fertilization, because it enhances the ability of spermatozoa to detach from the wall of the oviduct, to move around in the labyrinthine lumen of the oviduct, to penetrate mucous
H C, Ho, S S, Suarez
openaire   +2 more sources

Acrylate-derived RAFT polymers for enzyme hyperactivation – Boosting the α-chymotrypsin enzyme activity using tailor-made poly(2-carboxyethyl)acrylate (PCEA)

, 2023
We study the hyperactivation of α-chymotrypsin (α-CT) here, using acrylate-derived PCEA polymer. Enzyme activity assays revealed a pronounced enzyme hyperactivation capacity being superior to widespread PAA polymers.
Matthias , Schenderlein, Nazim , Pallab, Yannic , Müllers, Ahmad Shahir , Sadr, Ulrich , Glebe, Mehdi, D. Davari, Martin , Reifarth   +6 more
core   +1 more source

Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice

The Journal of Reproduction and Development, 2023
Progesterone (P) enhances spermatozoal hyperactivation, a capacitation event. Hyperactivation is associated with successful in vitro fertilization (IVF). In this study, we examined the effects of P on hyperactivation and IVF in mice.
Risa SUZUKI, Masakatsu FUJINOKI
doaj   +1 more source

Regulation of hyperactivation by PPP2 in hamster spermatozoa [PDF]

Reproduction, 2010
Abstract It has been widely accepted that serine/threonine protein phosphatases (PPPs) are associated with the regulation of sperm hyperactivation. In the present study, we examined the types of PPPs associated with the regulation of hamster sperm hyperactivation.
Tatsuya, Suzuki, Masakatsu, Fujinoki, Hiroaki, Shibahara, Mitsuaki, Suzuki   +3 more
openaire   +2 more sources

Control of hyperactivation in sperm [PDF]

Human Reproduction Update, 2008
Sperm hyperactivation is critical to fertilization, because it is required for penetration of the zona pellucida. Hyperactivation may also facilitate release of sperm from the oviductal storage reservoir and may propel sperm through mucus in the oviductal lumen and the matrix of the cumulus oophorus.
openaire   +2 more sources

Why looking at the whole hippocampus is not enough – a critical role for anteroposterior axis, subfield and activation analyses to enhance predictive value of hippocampal changes for Alzheimer’s disease diagnosis.

Frontiers in Cellular Neuroscience, 2014
The hippocampus is one of the earliest affected brain regions in Alzheimer´s disease (AD) and its dysfunction is believed to underlie the core feature of the disease- memory impairment.
Aleksandra eMaruszak, Sandrine eThuret
doaj   +1 more source

Regulation of hyperactivation of hamster spermatozoa by progesterone [PDF]

Reproductive Medicine and Biology, 2008
Aim:  Although it is accepted that progesterone (P) induces acrosome reaction through non‐genomic regulation, it is not well known if P also affects hyperactivation of sperm.Methods:  Hamster spermatozoa were hyperactivated by incubation for 4 h on modified Tyrode's albumin lactate pyruvate medium and recorded on a DVD via a charge‐coupled device ...
Takao, Noguchi, Masakatsu, Fujinoki, Masafumi, Kitazawa, Noriyuki, Inaba   +3 more
openaire   +2 more sources

In Vitro Exposure to Glucose Alters the Expression of Phosphorylated Proteins in Platelets

Biomedicines, 2023
Diabetes mellitus (DM) is a pro-thrombotic state that can potentially cause serious cardiovascular complications. Platelet hyperactivation plays an important role in these pathological processes, however there is little or no information on the effect of
Mizuho Suzuki, Kyosuke Takeshita, Yuki Kitamura, Marie Kuribayashi, Zhenlie Huang, Gaku Ichihara, Shinji Oikawa, Sahoko Ichihara   +7 more
doaj   +1 more source