Analysis of Ca2+-mediated sperm motility to evaluate the functional normality of the sperm-specific Ca2+ channel, CatSper [PDF]
Frontiers in Cell and Developmental BiologyCa2+ is a key secondary messenger that modulates sperm motility by tuning flagellar movement in various species. The sperm-specific Ca2+ channel, CatSper, is a primary Ca2+ gate that is essential for male fertility in mammals.
Jae Yeon Hwang, Jae Yeon Hwang
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The Olfactory Receptor Olfr25 Mediates Sperm Dysfunction Induced by Low-Dose Bisphenol A through the CatSper-Ca2+ Signaling Pathway [PDF]
ToxicsBisphenol A (BPA), a typical endocrine disruptor, is known to have various adverse effects on the male reproductive system. However, the toxic effects and mechanisms of low-dose BPA have not yet been fully explored.
Jing Gu +7 more
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The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm [PDF]
Frontiers in Cell and Developmental Biology, 2023 The sperm-specific channel CatSper (cation channel of sperm) controls the intracellular Ca2+ concentration ([Ca2+]i) and plays an essential role in sperm function.
Lydia Wehrli +18 more
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CatSper mediates not only chemotactic behavior but also the motility of ascidian sperm [PDF]
Frontiers in Cell and Developmental Biology, 2023 Introduction: Sperm motility, including chemotactic behavior, is regulated by changes in the intracellular Ca2+ concentration, and the sperm-specific Ca2+ channel CatSper has been shown to play an important role in the regulation of intracellular Ca2 ...
Taiga Kijima +6 more
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High-throughput screening method for discovering CatSper inhibitors using membrane depolarization caused by external calcium chelation and fluorescent cell barcoding [PDF]
Frontiers in Cell and Developmental Biology, 2023 The exclusive expression of CatSper in sperm and its critical role in sperm function makes this channel an attractive target for contraception. The strategy of blocking CatSper as a male, non-hormonal contraceptive has not been fully explored due to the ...
Guillermina M. Luque +9 more
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Environmental pollutants and male infertility: Effects on CatSper
Ecotoxicology and Environmental SafetyInfertility is a growing health concern among many couples worldwide. Men account for half of infertility cases. CatSper, a sperm-specific Ca2+ channel, is expressed on the cell membrane of mammalian sperm.
Yuxin He +4 more
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The Chemosensing Role of CatSper in Mammalian Sperm: An Updated Review
Current Issues in Molecular Biology, 2023 After sperm enter the female reproductive tract, the physicochemical and biochemical microenvironment undergoes significant changes. In particular, the large changes in various ions encountered by sperm may alter the physiology of sperm, ultimately ...
Sulun Ke, Tao Luo
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Pharmacological Inactivation of CatSper Blocks Sperm Fertilizing Ability Independently of the Capacitation Status of the Cells: Implications for Non-hormonal Contraception [PDF]
Frontiers in Cell and Developmental Biology, 2021 Cation channel of sperm (CatSper), the main sperm-specific Ca2+ channel, plays a key role in mammalian fertilization, and it is essential for male fertility, becoming an attractive target for contraception.
Ludmila Curci +4 more
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The CatSper channel: a polymodal chemosensor in human sperm [PDF]
The EMBO Journal, 2012 The sperm-specific CatSper channel controls the intracellular Ca(2+) concentration ([Ca(2+)](i)) and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by progesterone and prostaglandins-female factors that stimulate Ca(2+) influx.
Christoph Brenker +8 more
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Prevention of Testicular Damage by Indole Derivative MMINA via Upregulated StAR and CatSper Channels with Coincident Suppression of Oxidative Stress and Inflammation: In Silico and In Vivo Validation [PDF]
Antioxidants, 2022 Cis-diamminedichloroplatinum (II) (CDDP) is a widely used antineoplastic agent with numerous associated side effects. We investigated the mechanisms of action of the indole derivative N’-(4-dimethylaminobenzylidene)-2-1-(4-(methylsulfinyl) benzylidene)-5-
Tayyaba Afsar +7 more
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