Results 11 to 20 of about 1,350 (163)
Environment International, 2022 Background: Ca2+-signaling controls sperm cell functions necessary for successful fertilization. Multiple endocrine disrupting chemicals have been found to interfere with normal Ca2+-signaling in human sperm cells through an activation of the sperm ...
Anders Rehfeld, Anna-Maria Andersson
exaly +3 more sources
Sperm hyperactivation and the CatSper channel: current understanding and future contribution of domestic animals [PDF]
Journal of Animal Science and TechnologyIn female tract, mammalian sperm develop hyperactivated motility which is a key physiological event for sperm to fertilize eggs. This motility change is triggered by Ca2+ influx via the sperm-specific Ca2+ channel, CatSper.
Jae Yeon Hwang
doaj +2 more sources
Activation of motility and chemotaxis in the spermatozoa [PDF]
Reproductive Medicine and BiologyBackground Sperm motility and chemotaxis are important early steps in the interaction between sperm and oocytes during fertilization. Understanding these processes is essential for their basic biological and clinical applications.
Manabu Yoshida, Kaoru Yoshida
doaj +2 more sources
Intracellular domain of CATSPER1 could serve as a cytoplasmic platform for redox processes in mammalian sperm [PDF]
Animal BioscienceObjective Mammalian sperm acquire fertilizing ability in the female reproductive tract and develop hyperactivated motility, which is indispensable for male fertility. Hyperactivated motility is initiated by Ca2+ influx via the sperm-specific ion channel,
Jingon Kim, Jae Yeon Hwang
doaj +2 more sources
Molecular basis of the higher-order assembly of CatSper
Proceedings of the National Academy of Sciences of the United States of AmericaCatSper serves as the primary Ca 2+ entry pathway in the principal piece of sperm flagellum and is crucial for sperm motility and fertility. Sperm lacking functional CatSper channels fail to undergo hyperactivation during fertilization, leading to complete male infertility.
Jianping Wu, Zhen Yan, Xuhui Zeng
exaly +3 more sources
Panax ginseng induces the expression of CatSper genes and sperm hyperactivation
Asian Journal of Andrology, 2014 The cation channel of sperm (CatSper) protein family plays important roles in male reproduction and infertility. The four members of this family are expressed exclusively in the testis and are localized differently in sperm. To investigate the effects of
Eun Hwa Park +4 more
doaj +3 more sources
Exposure to Cadmium Impairs Sperm Functions by Reducing CatSper in Mice [PDF]
Cellular Physiology and Biochemistry, 2017 Background: Cadmium (Cd), a common environmental heavy metal and endocrine disruptor, is known to exert toxic effects on the testes. However, the mechanisms accounting for its toxicity in mature spermatozoa remain unclear.
Hua-Feng Wang +9 more
doaj +3 more sources
The Olfactory Receptor Olfr25 Mediates Sperm Dysfunction Induced by Low-Dose Bisphenol A through the CatSper-Ca2+ Signaling Pathway [PDF]
ToxicsBisphenol A (BPA), a typical endocrine disruptor, is known to have various adverse effects on the male reproductive system. However, the toxic effects and mechanisms of low-dose BPA have not yet been fully explored.
Jing Gu +7 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2023 The exclusive expression of CatSper in sperm and its critical role in sperm function makes this channel an attractive target for contraception. The strategy of blocking CatSper as a male, non-hormonal contraceptive has not been fully explored due to the ...
Guillermina M. Luque +9 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 The sperm-specific Ca2+ channel CatSper registers chemical cues that assist human sperm to fertilize the egg. Prime examples are progesterone and prostaglandin E1 that activate CatSper without involving classical nuclear and G protein-coupled receptors ...
Janice K. Jeschke +15 more
doaj +1 more source