Results 11 to 20 of about 1,728 (186)
The Chemosensing Role of CatSper in Mammalian Sperm: An Updated Review
Current Issues in Molecular Biology, 2023 After sperm enter the female reproductive tract, the physicochemical and biochemical microenvironment undergoes significant changes. In particular, the large changes in various ions encountered by sperm may alter the physiology of sperm, ultimately ...
Sulun Ke, Tao Luo
doaj +4 more sources
The Catsper channel and its roles in male fertility: a systematic review [PDF]
Reproductive Biology and Endocrinology, 2017 The Catsper channel is a sperm-specific, Ca2+-permeable, pH-dependent, and low voltage-dependent channel that is essential for the hyperactivity of sperm flagellum, chemotaxis towards the egg, capacitation and acrosome reaction.
Xiang-hong Sun +6 more
doaj +5 more sources
3D structure and in situ arrangements of CatSper channel in the sperm flagellum [PDF]
Nature Communications, 2022 Sperm motility and male fertility requires function of the CatSper calcium channels. Here, using cryo-electron tomography, authors visualize the native in-cell 3D structure and higher-order organization of the CatSper as long zigzag rows along the sperm ...
Yanhe Zhao +12 more
doaj +6 more sources
Sperm are promiscuous and CatSper is to blame... [PDF]
The EMBO Journal, 2012 A sperm-specific cation channel (CatSper) facilitates the entry of calcium necessary for rapid changes in sperm motility allowing the cell to navigate the hurdles of the female reproductive tract and successfully to locate the egg. Brenker and colleagues
Barratt, CL +3 more
core +4 more sources
CatSper: a unique calcium channel of the sperm flagellum [PDF]
Current Opinion in Physiology, 2018 To overcome egg protective vestments and ensure successful fertilization, mammalian spermatozoa switch symmetrical progressive motility to a powerful, whip-like flagellar motion, known as hyperactivation.
Polina V Lishko +3 more
core +6 more sources
Science Signaling, 2011 Progesterone stimulates calcium influx in human sperm through the CatSper channel.
Elizabeth M. Adler
core +2 more sources
The CatSper channel: a polymodal chemosensor in human sperm [PDF]
The EMBO Journal, 2012 The sperm-specific CatSper channel controls the intracellular Ca(2+) concentration ([Ca(2+)](i)) and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by progesterone and prostaglandins-female factors that stimulate Ca(2+
Kaupp, U.B. +10 more
core +4 more sources
Cells, 2021 Males have evolved species-specifical sperm morphology and swimming patterns to adapt to different fertilization environments. In eutherians, only a small fraction of the sperm overcome the diverse obstacles in the female reproductive tract and ...
Jae Yeon Hwang +3 more
doaj +2 more sources
The action of physiological and synthetic steroids on the calcium channel CatSper in human sperm [PDF]
Frontiers in Cell and Developmental Biology, 2023 The sperm-specific channel CatSper (cation channel of sperm) controls the intracellular Ca2+ concentration ([Ca2+]i) and plays an essential role in sperm function.
Lydia Wehrli +18 more
doaj +3 more sources
SKF96365 modulates activity of CatSper channels in human sperm [PDF]
Molecular Human Reproduction, 2023 Exposure of human sperm to progesterone (P4) activates cation channel of sperm (CatSper) channels, inducing an intracellular Ca2+ concentration ([Ca2+]i) transient followed by repetitive [Ca2+]i activity (oscillations), which are believed to be ...
Brown, Sean G +19 more
core +4 more sources