Results 41 to 50 of about 1,728 (186)

Discovery and Characterization of Multiple Classes of Human CatSper Blockers

ChemMedChem, 2022
AbstractThe cation channel of sperm (CatSper) is a validated target for nonhormonal male contraception, but it lacks selective blockers, hindering studies to establish its role in both motility and capacitation. Via an innovative calcium uptake assay utilizing human sperm we discovered novel inhibitors of CatSper function from a high‐throughput ...
Erick J. Carlson, Rawle Francis, Yutong Liu, Ping Li, Maximilian Lyon, Celia M. Santi, Derek J. Hook, Jon E. Hawkinson, Gunda I. Georg   +8 more
openaire   +2 more sources

CatSperβ, a Novel Transmembrane Protein in the CatSper Channel Complex [PDF]

Journal of Biological Chemistry, 2007
Four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel.
Jin, Liu, Jingsheng, Xia, Kwang-Hyun, Cho, David E, Clapham, Dejian, Ren   +4 more
openaire   +2 more sources

The CatSper channel controls chemosensation in sea urchin sperm [PDF]

, 2015
Sperm guidance is controlled by chemical and physical cues. In many species, Ca2+ bursts in the flagellum govern navigation to the egg. In Arbacia punctulata, a model system of sperm chemotaxis, a cGMP signaling pathway controls these Ca2+ bursts.
Kaupp, U.B., Bönigk, W., Fridman, D., Kashikar, N., Kuhl, H., Windler, F., Jikeli, J., Poetsch, A., Flick, M., Goodwin, N., Alvarez, L., Seifert, R., Müller, A., Kremmer, E., Timmermann, B., Strünker, T., Kaupp, U., Trötschel, C., Pelzer, P., Kashikar, N.D.   +19 more
core   +1 more source

Genetic male infertility and mutation of CATSPER ion channels [PDF]

European Journal of Human Genetics, 2010
A clinically significant proportion of couples experience difficulty in conceiving a child. In about half of these cases male infertility is the cause and often genetic factors are involved. Despite advances in clinical diagnostics ∼50% of male infertility cases remain idiopathic.
Michael S, Hildebrand, Matthew R, Avenarius, Marc, Fellous, Yuzhou, Zhang, Nicole C, Meyer, Jana, Auer, Catherine, Serres, Kimia, Kahrizi, Hossein, Najmabadi, Jacques S, Beckmann, Richard J H, Smith   +10 more
openaire   +2 more sources

Comparative genomic analysis suggests that the sperm-specific sodium/proton exchanger and soluble adenylyl cyclase are key regulators of CatSper among the Metazoa

Zoological Letters, 2019
Background CatSper is a sperm-specific calcium ion (Ca2+) channel, which regulates sperm flagellar beating by tuning cytoplasmic Ca2+ concentrations. Although this Ca2+ channel is essential for mammalian fertilization, recent bioinformatics analyses have
Francisco Romero, Takuya Nishigaki
doaj   +1 more source

The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex [PDF]

, 2016
The basal fungus Allomyces macrogynus (A. macrogynus) produces motile male gametes displaying well-studied chemotaxis toward their female counterparts. This chemotaxis is driven by sirenin, a sexual pheromone released by the female gametes. The pheromone
Polina V. Lishko (1277544), Shameem Sultana Syeda, Rawle Francis, Jon E. Hawkinson, Melissa R. Miller, Hook, Derek, Clapham, David E, David E. Clapham (1277556), Carlson, Erick J, Polina V. Lishko, Gunda I. Georg, Jon E. Hawkinson (1277559), Syeda, Shameem Sultana, Hawkinson, Jon E, Rawle Francis (1277541), Francis, Rawle, Georg, Gunda I, Derek Hook (381279), Shameem Sultana Syeda (1277550), Erick J. Carlson (1277547), Derek Hook, Erick J. Carlson, Lishko, Polina V, Gunda I. Georg (1246845), David E. Clapham, Miller, Melissa R, Melissa R. Miller (1277553)   +26 more
core   +2 more sources

Increased mitochondrial activity upon CatSper channel activation is required for mouse sperm capacitation

Redox Biology, 2021
To fertilize an oocyte, sperm must undergo several biochemical and functional changes known as capacitation. A key event in capacitation is calcium influx through the cation channel of sperm (CatSper).
Juan J. Ferreira, Adriana Cassina, Pilar Irigoyen, Mariana Ford, Santiago Pietroroia, Nikita Peramsetty, Rafael Radi, Celia M. Santi, Rossana Sapiro   +8 more
doaj   +1 more source

Effects of Resistance Training on Serum Inflammatory Markers and CatSper 1-4 Protein Expression in Testis of OLETF Rats [PDF]

운동과학, 2017
PURPOSE This study was to investigate the effects of resistance exercise on serum inflammatory markers and CatSper 1-4 expression in testis of OLETF rats.
Min-Ki Lee, Se-Hwan Park, Jin-Hwan Yoon
doaj   +1 more source

Homozygous in-frame deletion inCATSPEREin a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity

Human Reproduction, 2018
Does a man (patient 1) with a previously described deficiency in principle cation channel of sperm (CatSper) function have a mutation in the CatSper-epsilon (CATSPERE) and/or CatSper-zeta (CATSPERZ) gene?Patient 1 has a homozygous in-frame 6-bp deletion in exon 18 (c.2393_2398delCTATGG, rs761237686) of CATSPERE.CatSper is the principal calcium channel ...
Sean G Brown, Melissa R Miller, Polina V Lishko, Douglas H Lester, Stephen J Publicover, Christopher L R Barratt, Sarah Martins Da Silva   +6 more
openaire   +4 more sources

Molecular cloning, spatial and temporal expression analysis of CatSper genes in the Chinese Meishan pigs

Reproductive Biology and Endocrinology, 2011
Background Sperm ion channel proteins (CatSpers) are essential for sperm hyperactivated motility, and then penetration through the zona pellucida. The CatSper class of proteins have well been characterized in the mouse and human.
Li Bichun, Wang Xiaoyan, Xie Yuxiu, Wu Han, Gao Bo, Song Chengyi, Chen Guohong, Mao Jiude   +7 more
doaj   +1 more source