Results 41 to 50 of about 1,915 (186)

Genomic identification, expression profiling, and functional characterization of CatSper channels in the bovine† [PDF]

, 2017
Cation channels of sperm (CatSper) are sperm-specific calcium channels with identified roles in the regulation of sperm function in humans, mice, and horses.
Hoey, David A., David A. Hoey, Anne-Marie English (5141153), Kieran G. Meade (11583287), English, Anne-Marie, Sinéad Cronin (12590035), David A. Hoey (11605833), Sinead Cronin, Kieran G. Meade, Fair, Sean, Johnson, Gillian P., Cronin, Sinead, Anne-Marie English, Sean Fair, Gillian P. Johnson (12579532), Seán Fair (5141156), Meade, Kieran G., Gillian P. Johnson   +17 more
core   +2 more sources

CatSperβ, a Novel Transmembrane Protein in the CatSper Channel Complex [PDF]

Journal of Biological Chemistry, 2007
Four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel.
Jin, Liu, Jingsheng, Xia, Kwang-Hyun, Cho, David E, Clapham, Dejian, Ren   +4 more
openaire   +2 more sources

In vitro investigation of endocrine disrupting effects of pesticides on Ca2+-signaling in human sperm cells through actions on the sperm-specific and steroid-activated CatSper Ca2+-channel

Environment International, 2022
Background: Ca2+-signaling controls sperm cell functions necessary for successful fertilization. Multiple endocrine disrupting chemicals have been found to interfere with normal Ca2+-signaling in human sperm cells through an activation of the sperm ...
Michala R. Birch, Mathias Johansen, Niels E. Skakkebæk, Anna-Maria Andersson, Anders Rehfeld   +4 more
doaj   +1 more source

CatSper ion channels: Bioinformatics analysis in Homo sapiens [PDF]

, 2013
Due to the availability of huge amount of molecular biology data, our main focus was to determine the protein structures, functions and their role in different molecular pathways.
Kanwal, S, Iqbal, H, Parveen, A, Mir, A, Khattak, JZ   +4 more
core   +1 more source

Comparative genomic analysis suggests that the sperm-specific sodium/proton exchanger and soluble adenylyl cyclase are key regulators of CatSper among the Metazoa

Zoological Letters, 2019
Background CatSper is a sperm-specific calcium ion (Ca2+) channel, which regulates sperm flagellar beating by tuning cytoplasmic Ca2+ concentrations. Although this Ca2+ channel is essential for mammalian fertilization, recent bioinformatics analyses have
Francisco Romero, Takuya Nishigaki
doaj   +1 more source

Discovery and Characterization of Multiple Classes of Human CatSper Blockers

ChemMedChem, 2022
AbstractThe cation channel of sperm (CatSper) is a validated target for nonhormonal male contraception, but it lacks selective blockers, hindering studies to establish its role in both motility and capacitation. Via an innovative calcium uptake assay utilizing human sperm we discovered novel inhibitors of CatSper function from a high‐throughput ...
Erick J. Carlson, Rawle Francis, Yutong Liu, Ping Li, Maximilian Lyon, Celia M. Santi, Derek J. Hook, Jon E. Hawkinson, Gunda I. Georg   +8 more
openaire   +2 more sources

Genetic male infertility and mutation of CATSPER ion channels [PDF]

European Journal of Human Genetics, 2010
A clinically significant proportion of couples experience difficulty in conceiving a child. In about half of these cases male infertility is the cause and often genetic factors are involved. Despite advances in clinical diagnostics ∼50% of male infertility cases remain idiopathic.
Michael S, Hildebrand, Matthew R, Avenarius, Marc, Fellous, Yuzhou, Zhang, Nicole C, Meyer, Jana, Auer, Catherine, Serres, Kimia, Kahrizi, Hossein, Najmabadi, Jacques S, Beckmann, Richard J H, Smith   +10 more
openaire   +2 more sources

Effects of Resistance Training on Serum Inflammatory Markers and CatSper 1-4 Protein Expression in Testis of OLETF Rats [PDF]

운동과학, 2017
PURPOSE This study was to investigate the effects of resistance exercise on serum inflammatory markers and CatSper 1-4 expression in testis of OLETF rats.
Min-Ki Lee, Se-Hwan Park, Jin-Hwan Yoon
doaj   +1 more source

Homozygous in-frame deletion inCATSPEREin a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity

Human Reproduction, 2018
Does a man (patient 1) with a previously described deficiency in principle cation channel of sperm (CatSper) function have a mutation in the CatSper-epsilon (CATSPERE) and/or CatSper-zeta (CATSPERZ) gene?Patient 1 has a homozygous in-frame 6-bp deletion in exon 18 (c.2393_2398delCTATGG, rs761237686) of CATSPERE.CatSper is the principal calcium channel ...
Sean G Brown, Melissa R Miller, Polina V Lishko, Douglas H Lester, Stephen J Publicover, Christopher L R Barratt, Sarah Martins Da Silva   +6 more
openaire   +4 more sources

The Fungal Sexual Pheromone Sirenin Activates the Human CatSper Channel Complex [PDF]

, 2016
The basal fungus Allomyces macrogynus (A. macrogynus) produces motile male gametes displaying well-studied chemotaxis toward their female counterparts. This chemotaxis is driven by sirenin, a sexual pheromone released by the female gametes. The pheromone
Polina V. Lishko (1277544), Shameem Sultana Syeda, Rawle Francis, Jon E. Hawkinson, Melissa R. Miller, Hook, Derek, Clapham, David E, David E. Clapham (1277556), Carlson, Erick J, Polina V. Lishko, Gunda I. Georg, Jon E. Hawkinson (1277559), Syeda, Shameem Sultana, Hawkinson, Jon E, Rawle Francis (1277541), Francis, Rawle, Georg, Gunda I, Derek Hook (381279), Shameem Sultana Syeda (1277550), Erick J. Carlson (1277547), Derek Hook, Erick J. Carlson, Lishko, Polina V, Gunda I. Georg (1246845), David E. Clapham, Miller, Melissa R, Melissa R. Miller (1277553)   +26 more
core   +2 more sources