CatSper channels are regulated by protein kinase A [PDF]
Journal of Biological Chemistry, 2018 Mammalian sperm must undergo capacitation as a preparation for entering into hyperactivated motility, undergoing the acrosome reaction, and acquiring fertilizing ability. One of the initial capacitation events occurs when sperm encounter an elevated HCO3- concentration.
Gerardo Orta +5 more
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Human sperm ion channel (dys)function:implications for fertilization [PDF]
, 2019 BACKGROUND: Intensive research on sperm ion channels has identified members of several ion channel families in both mouse and human sperm. Gene knock-out studies have unequivocally demonstrated the importance of the calcium and potassium conductances in ...
Barratt, Christopher L. R. +3 more
core +4 more sources
Sperm are promiscuous and CatSper is to blame… [PDF]
The EMBO Journal, 2012 The human spermatozoon is a remarkable cell. It is characterised by extremely small size, absence of most organelles, a lack of transcription or translation (DNA is tightly condensed and almost crystalline), extreme polarity and rapid motility. These unusual characteristics have presented great challenges to the application of traditional methods of ...
Barratt, Christopher L. R. +1 more
openaire +3 more sources
Progesterone significantly enhances the mobility of boar spermatozoa [PDF]
, 2013 Progesterone released from the cumulus cells of the oocyte causes a number of physiological responses in human sperm cells including hyperactivation, acrosome reaction and chemotaxis. We employed a validated sperm mobility assay, which involves measuring
Adya, Ashok K. +6 more
core +3 more sources
The antidepressant Sertraline inhibits CatSper Ca2+ channels in human sperm [PDF]
Human Reproduction, 2021 Abstract STUDY QUESTION Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm? SUMMARY ANSWER The SSRI antidepressant Sertraline (e.g.
Rahban, Rita +10 more
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Study the role of KSper current for controlling the Ca2+ influx and intracellular pHi in mouse spermatozoa by dominating membrane potentials [PDF]
Iraqi Journal of Veterinary Sciences, 2022 This work was aimed to explore the details of the ion channels gating and there physiological role in sperm in the future.Mouse spermatozoa express a pH-dependent K+ current (KSper) thought to induce hyperpolarization to enhance Ca2+ influx via alkaline ...
Suha Alghazal
doaj +1 more source
Single-cell analysis of [Ca2+]i signalling in sub-fertile men:characteristics and relation to fertilization outcome [PDF]
, 2018 STUDY QUESTIONWhat are the characteristics of progesterone-induced (CatSper-mediated) single cell [Ca2+]i signals in spermatozoa from sub-fertile men and how do they relate to fertilizing ability?SUMMARY ANSWERSingle cell analysis of progesterone-induced
Barratt, Christopher L.R. +7 more
core +4 more sources
Absolute proteomic quantification reveals design principles of sperm flagellar chemosensation [PDF]
, 2019 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Troetschel, C., Hamzeh, H., Alvarez, L., Pascal, R., Lavryk, F., Boenigk, W., Koerschen, H.
Alvarez, Luis +14 more
core +1 more source
Depolarization of sperm membrane potential is a common feature of men with subfertility and is associated with low fertilization rate at IVF [PDF]
, 2016 STUDY QUESTION. Are significant abnormalities in outward (K+) conductance and resting membrane potential (Vm) present in the spermatozoa of patients undertaking IVF and ICSI and if so, what is their functional effect on fertilization success?
Barratt, Christopher L. R. +9 more
core +6 more sources
Up-regulation of CatSper genes family by selenium [PDF]
Reproductive Biology and Endocrinology, 2009 Abstract Background CatSper1-4 are a unique family of sperm cation channels, which are exclusively expressed in the testis and play an important role in sperm motility and male fertility. Despite their vital role in male fertility, almost nothing is known about the factors regulating their expression.
Movahedin Mansoureh +2 more
openaire +3 more sources