Results 51 to 60 of about 2,942 (237)
Frontiers in Cell and Developmental Biology, 2021 To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract. A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated by membrane depolarization and intracellular alkalinization.
Juan J. Ferreira +5 more
doaj +1 more source
SKF96365 modulates activity of CatSper channels in human sperm
Molecular Human Reproduction, 2023 Abstract Exposure of human sperm to progesterone (P4) activates cation channel of sperm (CatSper) channels, inducing an intracellular Ca2+ concentration ([Ca2+]i) transient followed by repetitive [Ca2+]i activity (oscillations), which are believed to be functionally important.
Elis Torrezan-Nitao +6 more
openaire +3 more sources
The Catsper channel and its roles in male fertility: a systematic review
Reproductive Biology and Endocrinology, 2017 The Catsper channel is a sperm-specific, Ca2+-permeable, pH-dependent, and low voltage-dependent channel that is essential for the hyperactivity of sperm flagellum, chemotaxis towards the egg, capacitation and acrosome reaction.
Xiang-hong Sun +6 more
doaj +1 more source
Complex CatSper-dependent and independent [Ca2+]i signalling in human spermatozoa induced by follicular fluid [PDF]
, 2017 STUDY QUESTION: Does progesterone in human follicular fluid (hFF) activate CatSper and do other components of hFF modulate this effect and/or contribute separately to hFF-induced Ca2+ signaling?SUMMARY ANSWER: hFF potently stimulates CatSper and ...
Barratt, Christopher L.R. +7 more
core +4 more sources
Simultaneous knockout of Slo3 and CatSper1 abolishes all alkalization- and voltage-activated current in mouse spermatozoa [PDF]
, 2013 During passage through the female reproductive tract, mammalian sperm undergo a maturation process termed capacitation that renders sperm competent to produce fertilization.
Clapham, David E. +4 more
core +2 more sources
CatSper: a unique calcium channel of the sperm flagellum [PDF]
Current Opinion in Physiology, 2018 To overcome egg protective vestments and ensure successful fertilization, mammalian spermatozoa switch symmetrical progressive motility to a powerful, whip-like flagellar motion, known as hyperactivation. The latter is triggered by a calcium influx through the sperm-specific, voltage-dependent, and alkalization-activated calcium channel of sperm ...
Lishko, Polina V, Mannowetz, Nadja
openaire +4 more sources
Drug discovery for male subfertility using high-throughput screening:a new approach to an unsolved problem [PDF]
, 2017 STUDY QUESTIONCan pharma drug discovery approaches be utilized to transform investigation into novel therapeutics for male infertility?SUMMARY ANSWERHigh-throughput screening (HTS) is a viable approach to much-needed drug discovery for male factor ...
Barratt, Christopher L. R. +9 more
core +6 more sources
CatSperĪ², a Novel Transmembrane Protein in the CatSper Channel Complex [PDF]
Journal of Biological Chemistry, 2007 Four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel.
Jin, Liu +4 more
openaire +2 more sources
Zoological Letters, 2019 Background CatSper is a sperm-specific calcium ion (Ca2+) channel, which regulates sperm flagellar beating by tuning cytoplasmic Ca2+ concentrations. Although this Ca2+ channel is essential for mammalian fertilization, recent bioinformatics analyses have
Francisco Romero, Takuya Nishigaki
doaj +1 more source
A Novel Gene Required for Male Fertility and Functional CATSPER Channel Formation in Spermatozoa [PDF]
, 2014 Summary Calcium signaling is critical for successful fertilization. In spermatozoa, capacitation, hyperactivation of motility, and the acrosome reaction are all mediated by increases in intracellular Ca2+.
Chung, Jean-Ju +4 more
core +1 more source