Results 71 to 80 of about 2,942 (237)

Investigation of the effect of diazinon on CatSper 1 gene expression, sperm motility and germinal epithelium thickness in adult male mice [PDF]

مجله علمی دانشگاه علوم پزشکی کردستان, 2020
Background and Aim: Genetic changes and mutations in the genes involved in spermatogenesis can occur by environmental and congenital factors. Considering, the extensive use of diazinon in the farms and because we found no study on the effects of diazinon
hamid reza faragnezhad, shabnam mohammadi, seyed morteza Seifati, atena mansouri, reyhaneh mahmoodian   +4 more
doaj   +1 more source

Biphasic Role of Calcium in Mouse Sperm Capacitation Signaling Pathways [PDF]

, 2015
Mammalian sperm acquire fertilizing ability in the female tract in a process known as capacitation. At the molecular level, capacitation is associated with up-regulation of a cAMP-dependent pathway, changes in intracellular pH, intracellular Ca2+, and an
Alvau, Antonio, Darszon, Alberto, Escoffier, Jessica, García Vázquez, Francisco A., Krapf, Dario, Navarrete, Felipe A., Salicioni, Ana M., Sánchez Cárdenas, Claudia, Visconti, Pablo E.   +8 more
core   +1 more source

Ca2+ ionophore A23187 can make mouse spermatozoa capable of fertilizing in vitro without activation of cAMP-dependent phosphorylation pathways [PDF]

, 2013
Ca2+ ionophore A23187 is known to induce the acrosome reaction of mammalian spermatozoa, but it also quickly immobilizes them. Although mouse spermatozoa were immobilized by this ionophore, they initiated vigorous motility (hyperactivation) soon after ...
Darszon, Alberto, Hino,Toshiaki, Krapf, Dario, Sánchez Cárdenas, Claudia, Tateno, Hiroyuki, Visconti, Pablo E., Yanagimachi, Ryuzo   +6 more
core   +2 more sources

Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm

Frontiers in Cell and Developmental Biology, 2020
Mammalian oocytes are enveloped by the zona pellucida (ZP), an extracellular matrix of glycoproteins. In sperm, stimulation with ZP proteins evokes a rapid Ca2+ influx via the sperm-specific, pH-sensitive Ca2+ channel CatSper.
Melanie Balbach, Hussein Hamzeh, Jan F. Jikeli, Christoph Brenker, Christian Schiffer, Jan N. Hansen, Pia Neugebauer, Christian Trötschel, Luca Jovine, Ling Han, Harvey M. Florman, U. Benjamin Kaupp, U. Benjamin Kaupp, Timo Strünker, Dagmar Wachten   +14 more
doaj   +1 more source

Continuous behavioural 'switching' in human spermatozoa and its regulation by Ca²⁺-mobilising stimuli [PDF]

, 2019
Human sperm show a variety of different behaviours (types of motility) that have different functional roles. Previous reports suggest that sperm may reversibly switch between these behaviours.
Achikanu, Cosmas, Correia, Joao, Da Silva, Sarah Martins, Giojalas, Laura, Guidobaldi, Hector, L. R. Barratt, Christopher, Publicover, Stephen   +6 more
core   +4 more sources

Transmission Ratio Distortion Detection Using Microsatellite and Single Nucleotide Polymorphism Markers in Hanwoo of Gyeongnam Province

Animal Genetics, Volume 57, Issue 2, April 2026.
ABSTRACT This study aimed to identify and compare transmission ratio distortion (TRD) patterns using microsatellite (MS) markers and single nucleotide polymorphism (SNP) markers in a Hanwoo population from Gyeongnam Province. The objective was to construct parent‐offspring trios and investigate TRD patterns that may influence mortality and economic ...
Ji‐Yeong Kim, Ho‐Chan Kang, Cheol‐Hyun Myung, Hyun‐Tae Lim   +3 more
wiley   +1 more source

The Oxytocin Receptor in Spermatozoa May Originate From Both Spermatogenesis and Epididymal Maturation, and Regulates Capacitation

Andrology, Volume 14, Issue 3, Page 747-765, March 2026.
Abstract Background The oxytocin receptor (OR) is a G‐protein‐coupled receptor recently identified in human spermatozoa, whose origin and role in sperm physiology remain unknown. Objectives In this study, using the pig as a model, we examine the presence of the OR in ejaculated spermatozoa through immunofluorescence and immunoblotting, and investigate ...
Jesús Martínez‐Hernández, Ferran Garriga, Adeel Ahmad, Lorena Padilla, Carolina Maside, Sergi Bonet, Isabel Barranco, Jordi Roca, Luis Miguel Pastor, Marc Yeste   +9 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2015/16:Voltage-gated ion channels [PDF]

, 2015
The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org),
,, Alexander, Stephen Ph, Benson, Helen E, Catterall, William A, Davies, Jamie A, Faccenda, Elena, Kelly, Eamonn, Marrion, Neil, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +4 more sources

Calpain‐1 and Cholesterol Regulate the Dynamics of the Lipid Membrane Domains Essential for Suitable Capacitation and Acrosomal Reactions

Journal of Cellular Physiology, Volume 241, Issue 2, February 2026.
The role of calpain‐1 and cholesterol during capacitation. The activation of calpain‐1 and cholesterol redistribution directs distinct events involved in capacitation, including the degradation of the spectrin cytoskeleton, protein phosphorylation at Tyr, actin polymerization, lipid rafts remodeling, and calcium influx, among others. ABSTRACT Calpain‐1
Aide A. Muñoz‐Sánchez, Monica L. Salgado‐Lucio, Coral Y. Jorge‐Cruz, Ana L. Roa‐Espitia, Rafael Baltiérrez‐Hoyos, Enrique O. Hernández‐González   +5 more
wiley   +1 more source

CatSper has a Calcium-Permeable Voltage Sensor Domain [PDF]

Biophysical Journal, 2016
CatSper channel, a cation channel expressed specifically in testis, is essential for fertilization in mice. It is believed that CatSper channel is formed by four α subunits, CatSper1, CatSper2, CatSper3 and CatSper4, as a hetero tetramer. Each subunit has six trans-membrane segments (S1-S6).
Arima, Hiroki, Tsutsui, Hidekazu, Takeshita, Kohei, Nakagawa, Atsushi, Sakamoto, Ayako, Yoshida, Manabu, Okamura, Yasushi   +6 more
openaire   +1 more source