Results 71 to 80 of about 1,728 (186)
CatSper: The complex main gate of calcium entry in mammalian spermatozoa
Molecular and Cellular Endocrinology, 2020 Calcium ions (Ca2+) are involved in nearly every aspect of cellular life. They are one of the most abundant elements in mammals and play a vital role in physiological and biochemical processes acting mainly as intracellular messengers. In spermatozoa, several key functions are regulated by cytoplasmic Ca2+ concentration such as sperm capacitation ...
Rahban, Rita, Nef, Serge
openaire +4 more sources
Frontiers in Cell and Developmental BiologyCa2+ is a key secondary messenger that modulates sperm motility by tuning flagellar movement in various species. The sperm-specific Ca2+ channel, CatSper, is a primary Ca2+ gate that is essential for male fertility in mammals.
Jae Yeon Hwang, Jae Yeon Hwang
doaj +1 more source
Molecular Reproduction and Development, Volume 92, Issue 9, September 2025.ABSTRACT The increasing focus on understanding spermatozoa mechanisms in rodents aims to enhance reproductive stability and support conservation efforts, particularly for ecologically significant and declining species like the red‐rumped agouti. We aimed to evaluate the interaction between capacitation media and time, testing BSA concentrations—low (4 ...
Lhara Ricarliany Medeiros de Oliveira +9 more
wiley +1 more source
Numerical values of the constants used in CatSper gating equations.
, 2021 Numerical values of the constants used in CatSper gating equations.
Alberto Darszon (209558) +4 more
core +1 more source
eLife, 2020 Out of millions of ejaculated sperm, a few reach the fertilization site in mammals. Flagellar Ca2+ signaling nanodomains, organized by multi-subunit CatSper calcium channel complexes, are pivotal for sperm migration in the female tract, implicating ...
Lukas Ded +4 more
doaj +1 more source
Antioxidants, 2022 Cis-diamminedichloroplatinum (II) (CDDP) is a widely used antineoplastic agent with numerous associated side effects. We investigated the mechanisms of action of the indole derivative N’-(4-dimethylaminobenzylidene)-2-1-(4-(methylsulfinyl) benzylidene)-5-
Tayyaba Afsar +7 more
doaj +1 more source
Mating system variation and gene expression in the male reproductive tract of Peromyscus mice
Molecular Ecology, Volume 34, Issue 15, August 2025.Abstract Genes involved in reproduction often evolve rapidly at the sequence level due to postcopulatory sexual selection (PCSS) driven by male–male competition and male–female sexual conflict, but the impact of PCSS on gene expression has been under‐explored.
Erin R. Voss, Michael W. Nachman
wiley +1 more source
Inhibition of CatSper and Hv1 Channels and NOX5 Enzyme Affect Progesterone-Induced Increase of Intracellular Calcium Concentration and ROS Generation in Human Sperm [PDF]
Iranian Journal of Medical Sciences, 2019 Background: Normal sperm function depends on appropriate intracellular calcium (Cai2+) and reactive oxygen species (ROS) levels. Calcium activates NADPH oxidase-5 (NOX5) that leads to ROS generation. The calcium channel of sperm (CatSper) is activated by
Hamideh Ghanbari +3 more
doaj +1 more source
How exome sequencing improves the diagnostics and management of men with non‐syndromic infertility
Andrology, Volume 13, Issue 5, Page 1011-1024, July 2025.Abstract Male infertility affects approximately 17% of all men and represents a complex disorder in which not only semen parameters such as sperm motility, morphology, and number of sperm are highly variable, but also testicular phenotypes range from normal spermatogenesis to complete absence of germ cells.
Birgit Stallmeyer +2 more
wiley +1 more source
eLife, 2017 We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male ...
Jean-Ju Chung +9 more
doaj +1 more source