Results 71 to 80 of about 1,350 (163)
Hyperactivation is sufficient to release porcine sperm from immobilized oviduct glycans
Scientific Reports, 2022 Fertilizing sperm are retained by adhesion to specific glycans on the epithelium of the oviduct forming a reservoir before sperm are released from the reservoir so fertilization can ensue.
Momal Sharif +7 more
doaj +1 more source
Isolated asthenozoospermia: What should we know? A narrative review of literature
UroPrecision, Volume 3, Issue 2, Page 73-86, June 2025.ABSTRACT Male infertility contributes to 20%–70% of infertile couple cases worldwide. One of the key challenges in this area is asthenozoospermia or reduced sperm motility. A particular subset, known as isolated asthenozoospermia (iASZ), in which low motility occurs without abnormalities in sperm count or shape, often goes unnoticed and is not well ...
Ahmed Eissa +7 more
wiley +1 more source
eLife, 2017 We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male ...
Jean-Ju Chung +9 more
doaj +1 more source
FASEB BioAdvances, Volume 7, Issue 6, June 2025.Long‐term steroid use can elevate intraocular pressure (IOP) and lead to steroid‐induced glaucoma by promoting extracellular matrix (ECM) accumulation in the trabecular meshwork (TM). This study demonstrates that bone morphogenetic protein‐7 (BMP‐7), delivered via a micellized protein transduction domain (mPTD), effectively inhibits steroid‐induced ECM
Eun Woo Kim +9 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 12, Page 2694-2712, June 2025.Abstract Background and Purpose Loss of function of the sperm‐specific Ca2+ channel CatSper is a common channelopathy that causes male infertility. CatSper controls the intracellular Ca2+ concentration and, thereby, the motility of human sperm. Activation of CatSper by oviductal ligands evokes a transient Ca2+ increase, which entails changes in the ...
Leonie Herrmann +11 more
wiley +1 more source
Molecular Ecology, Volume 34, Issue 9, May 2025.ABSTRACT Coastal seawater hypoxia is increasing in temperate estuaries under global climate change, yet it is unknown how low oxygen conditions affect most estuarine species. We found that hypoxia has increased since the 1990s in an estuary hosting the sea anemone Nematostella vectensis (Jacques Cousteau National Estuarine Research Reserve, New Jersey,
Benjamin H. Glass +5 more
wiley +1 more source
Recent Advances in Mammalian Olfactory Receptor Function and Structure
Sensory Neuroscience, Volume 1, Issue 1, April 2025.Olfactory receptors (ORs), a subset of G protein‐coupled receptors (GPCRs), mediate odor detection in sensory neurons and regulate diverse physiological functions across tissues. Their roles in metabolism, immunity, and neural processes underscore their therapeutic relevance. Recent high‐resolution Cryo‐EM studies have unveiled OR activation mechanisms,
Hongxi Qin +9 more
wiley +1 more source
Investigation In Vitro Expression of CatSper Sub Fragment followed by Production of Polyclonal Antibody: Potential Candidate for The Next Generation of Non Hormonal Contraceptive [PDF]
Cell Journal, 2012 Objective: CatSper is a voltage-sensitive calcium channel that is specifically expressed in the testis and it has a significant role in sperm performance. CatSper (1-4) ion channel subunit genes, causes sperm cell hyperactivation and male fertility.
Mahboobeh Nazari +4 more
doaj
The Journal of Clinical InvestigationThe infertility of many couples rests on an enigmatic dysfunction of the man’s sperm. To gain insight into the underlying pathomechanisms, we assessed the function of the sperm-specific multisubunit CatSper-channel complex in the sperm of almost 2,300 ...
Samuel Young +24 more
doaj +1 more source
Reproductive Biology and Endocrinology, 2003 Background CatSper1 and CatSper2 are two recently identified channel-like proteins, which show sperm specific expression patterns. Through targeted mutagenesis in the mouse, CatSper1 has been shown to be required for fertility, sperm motility and for ...
Reynolds Lindsey +4 more
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