Results 71 to 80 of about 1,915 (186)

Analysis of Ca2+-mediated sperm motility to evaluate the functional normality of the sperm-specific Ca2+ channel, CatSper

Frontiers in Cell and Developmental Biology
Ca2+ is a key secondary messenger that modulates sperm motility by tuning flagellar movement in various species. The sperm-specific Ca2+ channel, CatSper, is a primary Ca2+ gate that is essential for male fertility in mammals.
Jae Yeon Hwang, Jae Yeon Hwang
doaj   +1 more source

Inhibition of Autophagy in Heat-Stressed Sperm of Adult Mice: A Possible Role of Catsper1, 2 Channel Proteins

Journal of Tropical Medicine, 2023
Objective. Various phenomena guarantee gamete maturation and formation at all stages of evolution, one of which is autophagy playing a critical role in the final morphology of gametes, particularly sperms.
Malihe Soltani, Majid Rahmati, Mohammad Reza Nikravesh, Shahin Saeedi Nejat, Mahdi Jalali   +4 more
doaj   +1 more source

CatSper and Two-Pore channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]

, 2019
CatSper channels (CatSper1-4, nomenclature as agreed by NC-IUPHAR [13]) are putative 6TM, voltage-gated, alkalinization-activated calcium permeant channels that are presumed to assemble as a tetramer of α-like subunits and mediate the current ...
Chung, Jean-Ju, Ren, Dejian, Clapham, David E., Garbers, David L.   +3 more
core   +1 more source

Lycium barbarum polysaccharides enhance testicular spermatogenesis in d‐galactose‐induced aging rats via calcium signaling

Andrology, Volume 14, Issue 2, Page 496-515, February 2026.
Abstract Background Lycium barbarum polysaccharide (LBP) has long been recognized as having a wide range of beneficial properties for improving proliferation. However, the protective effects and specific mechanisms of d‐galactose‐induced testicular dysfunction in reproductively senescent rats are not fully understood.
Wenxin Ma, Chang Liu, Jing Pu, Ziyu Liu, Na Hu, Li Yang, Dongmei Chen, Hongmei Li, HuiMing Ma   +8 more
wiley   +1 more source

Influences of 5‐Hydroxytryptamine Receptor Agonists on Spermatozoal Hyperactivation and In Vitro Fertilization Success in Mice

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACTPurposeIn mice, 5‐hydroxytryptamine (5‐HT) enhances hyperactivation through 5‐HT2, 5‐HT3, 5‐HT4, and 5‐HT7 receptors and increases in vitro fertilization (IVF) success through the 5‐HT4 receptor. In the present study, we examined the effects of 5‐HT receptor agonists on motility, hyperactivation, motility kinematics, and IVF success in mice ...
Gaku Nakamura, Masakatsu Fujinoki, Takao Kamai   +2 more
wiley   +1 more source

Assisted Sperm Fusion Insemination: A Fusion‐Based Approach to Fertilization Without Mechanical Oolemma Penetration

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Intracytoplasmic sperm injection (ICSI) is widely used in assisted reproductive technology and achieves fertilization by directly injecting a spermatozoon into the oocyte cytoplasm. However, it requires deliberate disruption of the oolemma and bypasses physiological sperm–oocyte membrane fusion.
Shota Hatakeyama
wiley   +1 more source

3D in situ imaging of the female reproductive tract reveals molecular signatures of fertilizing spermatozoa in mice

eLife, 2020
Out of millions of ejaculated sperm, a few reach the fertilization site in mammals. Flagellar Ca2+ signaling nanodomains, organized by multi-subunit CatSper calcium channel complexes, are pivotal for sperm migration in the female tract, implicating ...
Lukas Ded, Jae Yeon Hwang, Kiyoshi Miki, Huanan F Shi, Jean-Ju Chung   +4 more
doaj   +1 more source

Diethylstilbestrol activates CatSper and disturbs progesterone actions in human spermatozoa [PDF]

Human Reproduction, 2016
Is diethylstilbestrol (DES), a prototypical endocrine-disrupting chemical (EDC), able to induce physiological changes in human spermatozoa and affect progesterone actions?DES promoted Ca2+ flux into human spermatozoa by activating the cation channel of sperm (CatSper) and suppressed progesterone-induced Ca2+ signaling, tyrosine phosphorylation and ...
Qian-Xing, Zou, Zhen, Peng, Qing, Zhao, Hou-Yang, Chen, Yi-Min, Cheng, Qing, Liu, Yuan-Qiao, He, Shi-Qi, Weng, Hua-Feng, Wang, Tao, Wang, Li-Ping, Zheng, Tao, Luo   +11 more
openaire   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Introduction and Other Protein Targets

British Journal of Pharmacology, Volume 182, Issue S1, Page S1-S23, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, John A. Cidlowski, Anthony P. Davenport, Doriano Fabbro, Michael Spedding, Jörg Striessnig, Jane F. Armstrong, O. Peter Buneman, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Katelin E. Ahlers‐Dannen, Mohammed Alqinyah, Thiruma V. Arumugam, Christopher Bodle, Josephine Buo Dagner, Bandana Chakravarti, Shreoshi P. Choudhuri, Kirk M. Druey, Rory A. Fisher, Kyle J. Gerber, John R. Hepler, Shelley B. Hooks, Havish S. Kantheti, Behirda Karaj, Somayeh Layeghi‐Ghalehsoukhteh, Jae‐Kyung Lee, Zili Luo, Kirill Martemyanov, Luke D. Mascarenhas, Harrison McNabb, Carolina Montañez‐Miranda, Osita Ogujiofor, Hoa Phan, David L. Roman, Vincent Shaw, Benita Sjogren, Christopher Sobey, Mackenzie M. Spicer, Katherine E. Squires, Laurie Sutton, Menbere Wendimu, Thomas Wilkie, Keqiang Xie, Qian Zhang, Yalda Zolghadri   +51 more
wiley   +1 more source

Inhibition of CatSper and Hv1 Channels and NOX5 Enzyme Affect Progesterone-Induced Increase of Intracellular Calcium Concentration and ROS Generation in Human Sperm [PDF]

Iranian Journal of Medical Sciences, 2019
Background: Normal sperm function depends on appropriate intracellular calcium (Cai2+) and reactive oxygen species (ROS) levels. Calcium activates NADPH oxidase-5 (NOX5) that leads to ROS generation. The calcium channel of sperm (CatSper) is activated by
Hamideh Ghanbari, Sara Keshtgar, Hamid Reza Zare, Behrouz Gharesi-Fard   +3 more
doaj   +1 more source