Results 61 to 70 of about 1,350 (163)
Advanced Science, Volume 12, Issue 44, November 27, 2025.The quantitative proteomic and phosphoproteomic profiling reveals dynamic phosphorylation regulation of sperm morphogenesis. Kinase‐substrate phosphorylation network and phosphorylation module analysis, followed by in vivo knockdown and knockout analysis, identify TTBK2 and CSNK1G1 as key regulators of morphogenesis, including head, flagellar, and ...
Tianyu Zhu +25 more
wiley +1 more source
Molecular Reproduction and Development, Volume 92, Issue 9, September 2025.ABSTRACT The increasing focus on understanding spermatozoa mechanisms in rodents aims to enhance reproductive stability and support conservation efforts, particularly for ecologically significant and declining species like the red‐rumped agouti. We aimed to evaluate the interaction between capacitation media and time, testing BSA concentrations—low (4 ...
Lhara Ricarliany Medeiros de Oliveira +9 more
wiley +1 more source
eLife, 2020 Out of millions of ejaculated sperm, a few reach the fertilization site in mammals. Flagellar Ca2+ signaling nanodomains, organized by multi-subunit CatSper calcium channel complexes, are pivotal for sperm migration in the female tract, implicating ...
Lukas Ded +4 more
doaj +1 more source
Mating system variation and gene expression in the male reproductive tract of Peromyscus mice
Molecular Ecology, Volume 34, Issue 15, August 2025.Abstract Genes involved in reproduction often evolve rapidly at the sequence level due to postcopulatory sexual selection (PCSS) driven by male–male competition and male–female sexual conflict, but the impact of PCSS on gene expression has been under‐explored.
Erin R. Voss, Michael W. Nachman
wiley +1 more source
CatSper: The complex main gate of calcium entry in mammalian spermatozoa
Molecular and Cellular Endocrinology, 2020 Calcium ions (Ca2+) are involved in nearly every aspect of cellular life. They are one of the most abundant elements in mammals and play a vital role in physiological and biochemical processes acting mainly as intracellular messengers. In spermatozoa, several key functions are regulated by cytoplasmic Ca2+ concentration such as sperm capacitation ...
Rahban, Rita, Nef, Serge
openaire +4 more sources
Bisphenol A Diglycidyl Ether (BADGE) and Progesterone Do Not Induce Ca2+ Signals in Boar Sperm Cells
Frontiers in Physiology, 2020 AimExposure of boar sperm cells to Bisphenol A diglycidyl ether (BADGE) has been shown to lead to reproductive failure in sows, however, the mode of action is unknown. As we have recently shown that BADGE can interfere with Ca2 + signaling in human sperm
Anders Rehfeld +5 more
doaj +1 more source
Inhibition of CatSper and Hv1 Channels and NOX5 Enzyme Affect Progesterone-Induced Increase of Intracellular Calcium Concentration and ROS Generation in Human Sperm [PDF]
Iranian Journal of Medical Sciences, 2019 Background: Normal sperm function depends on appropriate intracellular calcium (Cai2+) and reactive oxygen species (ROS) levels. Calcium activates NADPH oxidase-5 (NOX5) that leads to ROS generation. The calcium channel of sperm (CatSper) is activated by
Hamideh Ghanbari +3 more
doaj +1 more source
How exome sequencing improves the diagnostics and management of men with non‐syndromic infertility
Andrology, Volume 13, Issue 5, Page 1011-1024, July 2025.Abstract Male infertility affects approximately 17% of all men and represents a complex disorder in which not only semen parameters such as sperm motility, morphology, and number of sperm are highly variable, but also testicular phenotypes range from normal spermatogenesis to complete absence of germ cells.
Birgit Stallmeyer +2 more
wiley +1 more source
Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies
Andrology, Volume 13, Issue 5, Page 1044-1064, July 2025.Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi +5 more
wiley +1 more source
Asymmetrically Positioned Flagellar Control Units Regulate Human Sperm Rotation
Cell Reports, 2018 Summary: Ion channels control sperm navigation within the female reproductive tract and, thus, are critical for their ability to find and fertilize an egg.
Melissa R. Miller +8 more
doaj +1 more source