Results 61 to 70 of about 2,942 (237)
, 2014 Human sperm cells rely on an unusual type of potassium ion ...
Clapham, David E
core +1 more source
Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models [PDF]
, 2016 Mammalian sperm acquire fertilizing capacity in the female tract in a process called capacitation. At the molecular level, capacitation requires protein kinase A activation, changes in membrane potential and an increase in intracellular calcium ...
Alvau, Antonio +12 more
core +2 more sources
NK Cells Respond to Haptens by the Activation of Calcium Permeable Plasma Membrane Channels. [PDF]
, 2016 Natural Killer (NK) cells mediate innate immunity to infected and transformed cells. Yet, NK cells can also mount hapten-specific recall responses thereby contributing to contact hypersensitivity (CHS). However, since NK cells lack antigen receptors that
Grandclément, C. +3 more
core +7 more sources
Discovery and Characterization of Multiple Classes of Human CatSper Blockers
ChemMedChem, 2022 AbstractThe cation channel of sperm (CatSper) is a validated target for nonhormonal male contraception, but it lacks selective blockers, hindering studies to establish its role in both motility and capacitation. Via an innovative calcium uptake assay utilizing human sperm we discovered novel inhibitors of CatSper function from a high‐throughput ...
Erick J. Carlson +8 more
openaire +2 more sources
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Voltage-gated ion channels [PDF]
, 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
, +11 more
core +5 more sources
Reproductive Biology and Endocrinology, 2011 Background Sperm ion channel proteins (CatSpers) are essential for sperm hyperactivated motility, and then penetration through the zona pellucida. The CatSper class of proteins have well been characterized in the mouse and human.
Li Bichun +7 more
doaj +1 more source
Electrophysiology of Concatameric Pannexin 1 Channels Reveals the Stoichiometry of C-Terminal Autoinhibition [PDF]
, 2011 Codi d'Art Públic: 8008-1 (La República); Reportatge realitzat als dies 4 i 18-7-1990Pericas, Enric (arquitecte); Viaplana, Albert (arquitecte i estructura); Viladomat Massanas, Josep (escultura);Joan Pie (Medalló); Piñón, Helio ...
Chiu, Yu-Hsin +7 more
core +1 more source
Effects of Fscb/Cabyr double gene knockout on reproductive capacity in male mice
Di-san junyi daxue xuebao, 2021 Objective To evaluate the value of CABYR protein and its complex with FSCB in maintaining sperm fertilization ability and investigate the possible mechanism of physiological function of the coruplex by observing the natural fertility of Fscb/Cabyr double
LI Zhongtai +6 more
doaj +1 more source
Mouse sperm membrane potential hyperpolarization is necessary and sufficient to prepare sperm for the acrosome reaction [PDF]
, 2012 Mammalian sperm are unable to fertilize the egg immediately after ejaculation; they acquire this capacity during migration in the female reproductive tract. This maturational process is called capacitation and in mouse sperm it involves a plasma membrane
Darszon, Alberto +7 more
core +1 more source
Regulation and roles of Ca2+ stores in human sperm. [PDF]
, 2015 [Ca(2)(+)]i signalling is a key regulatory mechanism in sperm function. In mammalian sperm the Ca(2)(+)-permeable plasma membrane ion channel CatSper is central to [Ca(2)(+)]i signalling, but there is good evidence that Ca(2)(+) stored in intracellular ...
Correia, Joao +2 more
core +3 more sources