Results 81 to 90 of about 1,728 (186)

Bisphenol A Diglycidyl Ether (BADGE) and Progesterone Do Not Induce Ca2+ Signals in Boar Sperm Cells

Frontiers in Physiology, 2020
AimExposure of boar sperm cells to Bisphenol A diglycidyl ether (BADGE) has been shown to lead to reproductive failure in sows, however, the mode of action is unknown. As we have recently shown that BADGE can interfere with Ca2 + signaling in human sperm
Anders Rehfeld, Anders Rehfeld, Noelia Mendoza, Raquel Ausejo, Niels Erik Skakkebæk, Niels Erik Skakkebæk   +5 more
doaj   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, Volume 13, Issue 5, Page 1044-1064, July 2025.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

Hyperactivation is sufficient to release porcine sperm from immobilized oviduct glycans

Scientific Reports, 2022
Fertilizing sperm are retained by adhesion to specific glycans on the epithelium of the oviduct forming a reservoir before sperm are released from the reservoir so fertilization can ensue.
Momal Sharif, Vincent Hickl, Gabriel Juarez, Xingjian Di, Karl Kerns, Peter Sutovsky, Nicolai Bovin, David J. Miller   +7 more
doaj   +1 more source

Isolated asthenozoospermia: What should we know? A narrative review of literature

UroPrecision, Volume 3, Issue 2, Page 73-86, June 2025.
ABSTRACT Male infertility contributes to 20%–70% of infertile couple cases worldwide. One of the key challenges in this area is asthenozoospermia or reduced sperm motility. A particular subset, known as isolated asthenozoospermia (iASZ), in which low motility occurs without abnormalities in sperm count or shape, often goes unnoticed and is not well ...
Ahmed Eissa, Khaled Almekaty, Ahmed Zoeir, Hussein Mamdoh, Ayman Mousa, Mohammed Abou‐elenein, Tarek Gameel, Maged Ragab   +7 more
wiley   +1 more source

Effects of Bone Morphogenetic Protein‐7 on Steroid‐Induced Extracellular Matrix Accumulation in Human Trabecular Meshwork Cells

FASEB BioAdvances, Volume 7, Issue 6, June 2025.
Long‐term steroid use can elevate intraocular pressure (IOP) and lead to steroid‐induced glaucoma by promoting extracellular matrix (ECM) accumulation in the trabecular meshwork (TM). This study demonstrates that bone morphogenetic protein‐7 (BMP‐7), delivered via a micellized protein transduction domain (mPTD), effectively inhibits steroid‐induced ECM
Eun Woo Kim, Jin‐Ok Choi, Min Kyung Chae, Jin‐Sol Lee, Chang Ha Lee, Jo Eun Um, Nam Hee Kim, Jihyeong Kim, Wungrak Choi, Chan Yun Kim   +9 more
wiley   +1 more source

Asymmetrically Positioned Flagellar Control Units Regulate Human Sperm Rotation

Cell Reports, 2018
Summary: Ion channels control sperm navigation within the female reproductive tract and, thus, are critical for their ability to find and fertilize an egg.
Melissa R. Miller, Samuel J. Kenny, Nadja Mannowetz, Steven A. Mansell, Michal Wojcik, Sarah Mendoza, Robert S. Zucker, Ke Xu, Polina V. Lishko   +8 more
doaj   +1 more source

Chemosensory signalling in human sperm is controlled by Ca2+ influx via CatSper and Ca2+ clearance via plasma membrane Ca2+ ATPases

British Journal of Pharmacology, Volume 182, Issue 12, Page 2694-2712, June 2025.
Abstract Background and Purpose Loss of function of the sperm‐specific Ca2+ channel CatSper is a common channelopathy that causes male infertility. CatSper controls the intracellular Ca2+ concentration and, thereby, the motility of human sperm. Activation of CatSper by oviductal ligands evokes a transient Ca2+ increase, which entails changes in the ...
Leonie Herrmann, Christoph Brenker, Teresa Mittermair, Vesna Bojovic, Jens Münchow, W. Felix Zhu, Carla Trugge, David Fußhöller, Jan Jikeli, Louisa Temme, U. Benjamin Kaupp, Timo Strünker   +11 more
wiley   +1 more source

A novel cross-species inhibitor to study the function of CatSper Ca²⁺ channels in sperm [PDF]

, 2018
Background and Purpose: Sperm from many species share the sperm-specific Ca2+ channel CatSper (cation channel of sperm) that controls the intracellular Ca2+ concentration and, thereby, the swimming behaviour.
Alvarez, Luis, Brenker, Christoph, Nitao, Elis, Berger, Thomas K., Balbach, Melanie, Stölting, Gabriel, Strünker, Timo, Wachten, Dagmar, Schiffer, Christian, Rennhack, Andreas, Fridman, Dmitry, Kierzek, Michelina, Kaupp, U. Benjamin, Zeng, Xu-Hui, Tamburrino, Lars, Publicover, Stephen, Baldi, Elisabetta, Cheng, Yi-Min   +17 more
core   +1 more source

Hypoxia Disrupts Sex‐Specific Physiology and Gene Expression Leading to Decreased Fitness in the Estuarine Sea Anemone Nematostella vectensis

Molecular Ecology, Volume 34, Issue 9, May 2025.
ABSTRACT Coastal seawater hypoxia is increasing in temperate estuaries under global climate change, yet it is unknown how low oxygen conditions affect most estuarine species. We found that hypoxia has increased since the 1990s in an estuary hosting the sea anemone Nematostella vectensis (Jacques Cousteau National Estuarine Research Reserve, New Jersey,
Benjamin H. Glass, Angela C. Ye, Cassidy N. Hemphill, Katelyn G. Jones, Anna G. Dworetzky, Katie L. Barott   +5 more
wiley   +1 more source

Recent Advances in Mammalian Olfactory Receptor Function and Structure

Sensory Neuroscience, Volume 1, Issue 1, April 2025.
Olfactory receptors (ORs), a subset of G protein‐coupled receptors (GPCRs), mediate odor detection in sensory neurons and regulate diverse physiological functions across tissues. Their roles in metabolism, immunity, and neural processes underscore their therapeutic relevance. Recent high‐resolution Cryo‐EM studies have unveiled OR activation mechanisms,
Hongxi Qin, Yuerong He, Hong Fu, Kexin Wang, Yan Bin, Changling Xu, Fan Wu, Jiali Wei, Jiangang Fang, Wei Yan   +9 more
wiley   +1 more source