Results 101 to 110 of about 2,942 (237)

How exome sequencing improves the diagnostics and management of men with non‐syndromic infertility

Andrology, Volume 13, Issue 5, Page 1011-1024, July 2025.
Abstract Male infertility affects approximately 17% of all men and represents a complex disorder in which not only semen parameters such as sperm motility, morphology, and number of sperm are highly variable, but also testicular phenotypes range from normal spermatogenesis to complete absence of germ cells.
Birgit Stallmeyer, Ann‐Kristin Dicke, Frank Tüttelmann   +2 more
wiley   +1 more source

Canal catiónico específico del espermatozoide: CatSper

TIP Revista Especializada en Ciencias Químico-Biológicas
El canal catiónico específico del espermatozoide (CatSper) es un canal conductor de calcio esencial para regular la movilidad hiperactivada y, en última instancia, la promoción de la fertilidad en los espermatozoides. Este canal se localiza en el flagelo del espermatozoide y está regulado por la alcalinización, el voltaje y diferentes moléculas ...
José Edwin Mendoza-Sánchez, Julio C. Chávez-Zamora, Ahiezer Rodríguez-Tobón, Adriana Morales Otal, Edith Arenas-Ríos   +4 more
openaire   +1 more source

CatSperζ regulates the structural continuity of sperm Ca2+ signaling domains and is required for normal fertility

eLife, 2017
We report that the Gm7068 (CatSpere) and Tex40 (CatSperz) genes encode novel subunits of a 9-subunit CatSper ion channel complex. Targeted disruption of CatSperz reduces CatSper current and sperm rheotactic efficiency in mice, resulting in severe male ...
Jean-Ju Chung, Kiyoshi Miki, Doory Kim, Sang-Hee Shim, Huanan F Shi, Jae Yeon Hwang, Xinjiang Cai, Yusuf Iseri, Xiaowei Zhuang, David E Clapham   +9 more
doaj   +1 more source

Bisphenol A Diglycidyl Ether (BADGE) and Progesterone Do Not Induce Ca2+ Signals in Boar Sperm Cells

Frontiers in Physiology, 2020
AimExposure of boar sperm cells to Bisphenol A diglycidyl ether (BADGE) has been shown to lead to reproductive failure in sows, however, the mode of action is unknown. As we have recently shown that BADGE can interfere with Ca2 + signaling in human sperm
Anders Rehfeld, Anders Rehfeld, Noelia Mendoza, Raquel Ausejo, Niels Erik Skakkebæk, Niels Erik Skakkebæk   +5 more
doaj   +1 more source

Exposure to selected pathogens in Geoffroy's cats and domestic carnivores from central Argentina [PDF]

, 2012
Wild carnivores share a high percentage of parasites and viruses with closely related domestic carnivores. Because of increased overlap and potential contact with domestic species, we conducted a retrospective serosurvey for 11 common carnivore pathogens
Ferreyra, Hebe del Valle, Marull, Carolina A., Pereira, Javier Adolfo, Rago, María Virginia, Uhart, Marcela María   +4 more
core   +1 more source

Human asthenozoospermia: Update on genetic causes, patient management, and clinical strategies

Andrology, Volume 13, Issue 5, Page 1044-1064, July 2025.
Abstract Background In mammals, sperm fertilization potential relies on efficient progression within the female genital tract to reach and fertilize the oocyte. This fundamental property is supported by the flagellum, an evolutionarily conserved organelle, which contains dynein motor proteins that provide the mechanical force for sperm propulsion and ...
Emma Cavarocchi, Maëva Drouault, Joao C. Ribeiro, Violaine Simon, Marjorie Whitfield, Aminata Touré   +5 more
wiley   +1 more source

Hyperactivation is sufficient to release porcine sperm from immobilized oviduct glycans

Scientific Reports, 2022
Fertilizing sperm are retained by adhesion to specific glycans on the epithelium of the oviduct forming a reservoir before sperm are released from the reservoir so fertilization can ensue.
Momal Sharif, Vincent Hickl, Gabriel Juarez, Xingjian Di, Karl Kerns, Peter Sutovsky, Nicolai Bovin, David J. Miller   +7 more
doaj   +1 more source

Partial Deletion of Chromosome 8 β-defensin Cluster Confers Sperm Dysfunction and Infertility in Male Mice [PDF]

, 2013
β-defensin peptides are a family of antimicrobial peptides present at mucosal surfaces, with the main site of expression under normal conditions in the male reproductive tract.
A Krutskikh, A Wiser, A Zaballos, AA Patil, AI Yudin, Alan Hart, BC Schutte, BO Schroeder, BS Abu, C Moser, C Semple, CA Semple, Chris L. Barratt, Christine Tyrrell, CX Zhou, DJ Adams, DS Johnston, EJ Hollox, F Semple, Fiona Kilanowski, Fiona Semple, G Morrison, Gregory S. Barsh, H Oliveira, H Sato, Heather MacPherson, HT Turunen, J Tao, Julia R. Dorin, KA Lesich, L Zalazar, Laura Lettice, LR Fraser, M Jin, MT Shanahan, N Inoue, N Tanphaichitr, P Chomczynski, P Weissgerber, Paul Devenney, Paul Perry, Perdita Barran, Peter Tennant, PV Lishko, RG Spelbrink, RJ Hardwick, S Publicover, S Tardif, S Tardif, S Tardif, Sheila Webb, Steve Tardif, Tina Baker, TL Tollner, Tracey Davey, UC Lange, VJ Laine, Y Yamaguchi, Y Zhao, Yu S. Zhou   +59 more
core   +5 more sources

Isolated asthenozoospermia: What should we know? A narrative review of literature

UroPrecision, Volume 3, Issue 2, Page 73-86, June 2025.
ABSTRACT Male infertility contributes to 20%–70% of infertile couple cases worldwide. One of the key challenges in this area is asthenozoospermia or reduced sperm motility. A particular subset, known as isolated asthenozoospermia (iASZ), in which low motility occurs without abnormalities in sperm count or shape, often goes unnoticed and is not well ...
Ahmed Eissa, Khaled Almekaty, Ahmed Zoeir, Hussein Mamdoh, Ayman Mousa, Mohammed Abou‐elenein, Tarek Gameel, Maged Ragab   +7 more
wiley   +1 more source

2-APB-potentiated channels amplify CatSper-induced Ca2+ signals in human sperm [PDF]

Biochemical Journal, 2012
Ca2+i signalling is pivotal to sperm function. Progesterone, the best-characterized agonist of human sperm Ca2+i signalling, stimulates a biphasic [Ca2+]i rise, comprising a transient and subsequent sustained phase. In accordance with recent reports that progesterone directly activates CatSper, the [Ca2+]i transient was detectable in the anterior ...
Lefièvre, Linda, Nash, Katherine, Mansell, Steven, Costello, Sarah, Punt, Emma, Correia, Joao, Morris, Jennifer, Kirkman-Brown, Jackson, Wilson, Stuart M., Barratt, Christopher L. R., Publicover, Stephen   +10 more
openaire   +2 more sources