Results 111 to 120 of about 2,942 (237)
Heads or tails? Structural events and molecular mechanisms that promote mammalian sperm acrosomal exocytosis and motility [PDF]
, 2011 Sperm structure has evolved to be very compact and compartmentalized to enable the motor (the flagellum) to transport the nuclear cargo (the head) to the egg.
Aghajanian, Haig K. +5 more
core +1 more source
FASEB BioAdvances, Volume 7, Issue 6, June 2025.Long‐term steroid use can elevate intraocular pressure (IOP) and lead to steroid‐induced glaucoma by promoting extracellular matrix (ECM) accumulation in the trabecular meshwork (TM). This study demonstrates that bone morphogenetic protein‐7 (BMP‐7), delivered via a micellized protein transduction domain (mPTD), effectively inhibits steroid‐induced ECM
Eun Woo Kim +9 more
wiley +1 more source
Asymmetrically Positioned Flagellar Control Units Regulate Human Sperm Rotation
Cell Reports, 2018 Summary: Ion channels control sperm navigation within the female reproductive tract and, thus, are critical for their ability to find and fertilize an egg.
Melissa R. Miller +8 more
doaj +1 more source
C2CD6 regulates targeting and organization of the CatSper calcium channel complex in sperm flagella [PDF]
, 2021 Yang Fang +8 more
openalex +1 more source
British Journal of Pharmacology, Volume 182, Issue 12, Page 2694-2712, June 2025.Abstract Background and Purpose Loss of function of the sperm‐specific Ca2+ channel CatSper is a common channelopathy that causes male infertility. CatSper controls the intracellular Ca2+ concentration and, thereby, the motility of human sperm. Activation of CatSper by oviductal ligands evokes a transient Ca2+ increase, which entails changes in the ...
Leonie Herrmann +11 more
wiley +1 more source
CatSper ion channels: Bioinformatics analysis in Homo sapiens
African Journal of Biotechnology, 2011 نظرًا لتوافر كمية هائلة من بيانات البيولوجيا الجزيئية، كان تركيزنا الرئيسي هو تحديد هياكل البروتين ووظائفه ودوره في المسارات الجزيئية المختلفة. إن التنبؤ بالهيكل ثلاثي الأبعاد للبروتين مهم في الطب والتكنولوجيا الحيوية. لا يجد الالتحام الجزيئي التفاعل بين البروتينات فحسب، بل أيضًا النماذج الدقيقة للطاقة لهذه البروتينات المتفاعلة ويساعد في زيادة تصميم ...
Kanwal, S +4 more
openaire +3 more sources
CatSper: The complex main gate of calcium entry in mammalian spermatozoa
Molecular and Cellular Endocrinology, 2020 Calcium ions (Ca2+) are involved in nearly every aspect of cellular life. They are one of the most abundant elements in mammals and play a vital role in physiological and biochemical processes acting mainly as intracellular messengers. In spermatozoa, several key functions are regulated by cytoplasmic Ca2+ concentration such as sperm capacitation ...
Rahban, Rita, Nef, Serge
openaire +3 more sources
Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm. [PDF]
J Membr BiolDubey NK, Kumar V, Goswami C.
europepmc +3 more sources
, 2020 Sperm are highly specialized cells, which have been subject to substantial evolutionary pressure. Whereas some sperm features are highly conserved, others have undergone major modifications.
Alvarez, L. +6 more
core +1 more source
Molecular Ecology, Volume 34, Issue 9, May 2025.ABSTRACT Coastal seawater hypoxia is increasing in temperate estuaries under global climate change, yet it is unknown how low oxygen conditions affect most estuarine species. We found that hypoxia has increased since the 1990s in an estuary hosting the sea anemone Nematostella vectensis (Jacques Cousteau National Estuarine Research Reserve, New Jersey,
Benjamin H. Glass +5 more
wiley +1 more source