Results 121 to 130 of about 2,942 (237)

Clinically relevant enhancement of human sperm motility using compounds with reported phosphodiesterase inhibitor activity [PDF]

, 2014
STUDY QUESTION: Can we identify compound(s) with reported phosphodiesterase inhibitor (PDEI) activity that could be added to human spermatozoa in vitro to enhance their motility without compromising other sperm functions?
Alasmari, Alasmari, Baker, Barratt, Baxendale, Bjorndahl, Christopher L.R. Barratt, Comhaire, Conti, Cooper, David, Fisch, Ford, Francis, Glenn, Harrison, HFEA, Horvath, Houslay, Huacuja, Hull, Hunnicutt, Irvine, Ivic, Lefièvre, Lefièvre, Lefièvre, Linda Lefièvre, Lorna Frame, Martin, Mortimer, Mrsny, Nassar, Negri, O'Connell, Oladipo A. Madamidola, Paul G. Wyatt, Publicover, Richter, Sarah J. Martins Da Silva, Sean G. Brown, Sousa, Steve Tardif, Stone, Tesarik, Tomlinson, Tomlinson, Torres-Flores, Tournaye, Tournaye, Van der Steeg, Wang, Yang, Yovich, Yovich   +54 more
core   +5 more sources

Recent Advances in Mammalian Olfactory Receptor Function and Structure

Sensory Neuroscience, Volume 1, Issue 1, April 2025.
Olfactory receptors (ORs), a subset of G protein‐coupled receptors (GPCRs), mediate odor detection in sensory neurons and regulate diverse physiological functions across tissues. Their roles in metabolism, immunity, and neural processes underscore their therapeutic relevance. Recent high‐resolution Cryo‐EM studies have unveiled OR activation mechanisms,
Hongxi Qin, Yuerong He, Hong Fu, Kexin Wang, Yan Bin, Changling Xu, Fan Wu, Jiali Wei, Jiangang Fang, Wei Yan   +9 more
wiley   +1 more source

Update on mammalian sperm capacitation : how much does the horse differ from other species?

, 2019
In contrast to various other mammalian species, conventional in vitro fertilization (IVF) with horse gametes is not reliably successful. In particular, stallion spermatozoa fails to penetrate the zona pellucida, most likely due to incomplete activation ...
De Schauwer, Catharina, Gadella, Bart, Heras Garcia, Sonia, Hoogewijs, Maarten, Leemans, Bart, Nelis, Hilde, Stout, Tom AE, Van Soom, Ann   +7 more
core   +1 more source

Essential role of CFTR in PKA-dependent phosphorylation, alkalinization, and hyperpolarization during human dperm capacitation [PDF]

, 2017
Mammalian sperm require to spend a limited period of time in the female reproductive tract to become competent to fertilize in a process called capacitation.
Austin, Berger, Bobadilla, Buffone, Buffone, Buffone, Buffone, Chang, Chen, Chen, Chen, Chávez, Chávez, De Jonge, De La Vega-Beltran, Demarco, Diao, Dirami, Dostmann, Ellsworth, Escoffier, Esteves, Figueiras-Fierro, Gabriel, Gadsby, Hernández-González, Ishiguro, José, Kase, Kujala, Köhn, l'Hoste, Laemmli, Leclerc, Li, Lishko, Lochner, Luconi, López-González, Ma, Melis, Mortimer, Muanprasat, Navarrete, Neill, Nishigaki, Nolan, Okamura, Rode, Schulz, Sheppard, Sorum, Stival, Stival, Tabcharani, Tang, Towbin, Visconti, Visconti, Wennemuth, Wertheimer, Xu, Zeng, Zeng   +63 more
core   +1 more source

Physiological role of potassium channels in mammalian germ cell differentiation, maturation, and capacitation

Andrology, Volume 13, Issue 2, Page 184-201, February 2025.
Abstract Background Ion channels are essential for differentiation and maturation of germ cells, and even for fertilization in mammals. Different types of potassium channels have been identified, which are grouped into voltage‐gated channels (Kv), ligand‐gated channels (Kligand), inwardly rectifying channels (Kir), and tandem pore domain channels (K2P).
Ariadna Delgado‐Bermúdez, Marc Yeste, Sergi Bonet, Elisabeth Pinart   +3 more
wiley   +1 more source

Exposure to Cadmium Impairs Sperm Functions by Reducing CatSper in Mice

Cellular Physiology and Biochemistry, 2017
Background: Cadmium (Cd), a common environmental heavy metal and endocrine disruptor, is known to exert toxic effects on the testes. However, the mechanisms accounting for its toxicity in mature spermatozoa remain unclear.
Hua-Feng Wang, Meng Chang, Ting-Ting Peng, Yi Yang, Na Li, Tao Luo, Yi-Min Cheng, Meng-Zhi Zhou, Xu-Hui Zeng, Li-Ping Zheng   +9 more
doaj   +1 more source

Roles of CatSper channels in the pathogenesis of asthenozoospermia and the therapeutic effects of acupuncture-like treatment on asthenozoospermia

, 2021
Zirun Jin, Dong Fang, Bo-Heng Liu, Jie Cai, Wenhao Tang, Hui Jiang, Guo‐Gang Xing   +6 more
openalex   +1 more source

Investigation In Vitro Expression of CatSper Sub Fragment followed by Production of Polyclonal Antibody: Potential Candidate for The Next Generation of Non Hormonal Contraceptive [PDF]

Cell Journal, 2012
Objective: CatSper is a voltage-sensitive calcium channel that is specifically expressed in the testis and it has a significant role in sperm performance. CatSper (1-4) ion channel subunit genes, causes sperm cell hyperactivation and male fertility.
Mahboobeh Nazari, Manouchehr Mirshahi, Seyed-Javad Mowla, Taravat Bamdad, Sina Sarikhani   +4 more
doaj  

An miR-200 Cluster on Chromosome 23 Regulates Sperm Motility in Zebrafish [PDF]

, 2018
Besides its well-documented roles in cell proliferation, apoptosis, and carcinogenesis, the function of the p53-microRNA axis has been recently revealed in the reproductive system.
Dan, Cheng, Gui, Jian-Fang, Jing, Jing, Ma, Wenge, Mei, Jie, Xiong, Shuting, Zhang, Jin   +6 more
core   +1 more source

CCR6 is required for ligand-induced CatSper activation in human sperm

Oncotarget, 2017
CatSper channel has been considered the principal sperm Ca2+ channel responsible for the cytosolic Ca2+ elevation required for various sperm functions necessary for fertilization [1-4]. However, the mechanism underlying the activation of CatSper channel by various physiological ligands remain incompletely understood.
Diao, RY, Wang, T, Fok, KL, Li, XF, Ruan, YC, Yu, MK, Cheng, YM, Chen, Y, Chen, H, Mou, LS, Cai, XY, Wang, Y, Cai, ZM, Zeng, XH, Chan, HC   +14 more
openaire   +4 more sources