Results 141 to 150 of about 1,350 (163)

Calcium Signaling Through CatSper Channels in Mammalian Fertilization

Physiology, 2010
The molecular mechanisms underlying Ca2+entry into sperm are now much more well defined thanks to direct recordings of mature sperm cells. This article reviews the function of a sperm-specific ion channel, CatSper. CatSpers have a clearly defined function in sperm's hyperactivated motility and are essential for male fertility.
Dejian, Ren, Jingsheng, Xia
openaire   +2 more sources

[CatSper and sperm hyperactivation].

Zhonghua nan ke xue = National journal of andrology, 2007
Elevation of sperm Ca2+ seems to be responsible for an asymmetric form of motility called hyperactivation, which is first seen near the time of fertilization. CatSper family proteins are putative cation channels expressed exclusively in the membranes of the sperm flagellum.
Li-juan, Kong, Yuan-yuan, Yang, Gen-lin, Wang   +2 more
openaire   +1 more source

A Model of CatSper Channel Mediated Calcium Dynamics in Mammalian Spermatozoa

Bulletin of Mathematical Biology, 2010
CatSpers are calcium (Ca(2+)) channels that are located along the principal piece of mammalian sperm flagella and are directly linked to sperm motility and hyperactivation. It has been observed that Ca(2+) entry through CatSper channels triggers a tail to head Ca(2+) propagation in mouse sperm, as well as a sustained increase of Ca(2+) in the head ...
Olson, Sarah D., Suarez, Susan S., Fauci, Lisa J.   +2 more
openaire   +3 more sources

N-acetylcysteine Improved Expression of FSHR, LHCGR, Catsper-1, Catsper-2, and SF-1 Genes in Testis of Rats with Varicocele

Reproductive Sciences
Varicocele, a condition of insufficient oxygen supply to testicular tissue leading to hypoxia, is a major factor contributing to male infertility. This study investigated the potential protective effects of N-acetylcysteine (NAC), a potent antioxidant, on sperm characteristics and hormonal receptor expression in a rat model of varicocele-induced ...
Majid Shokoohi, Mohammad Hossein Nasr Esfahani, Amir Afshin Khaki, Gilda Ghazi Soltani, Alireza Alihemmati, Linda Mohammadzadeh Boukani   +5 more
openaire   +2 more sources

Insights into sperm cell motility signaling through sNHE and the CatSpers

Molecular and Cellular Endocrinology, 2006
Successful natural reproduction normally requires vigorously motile spermatozoa. Using a signal peptide trapping strategy, we identified two new genes, a putative sperm Na+/H+ exchanger (sNHE) and the putative cation channel CatSper2, with unique and essential roles in sperm motility.
Timothy A, Quill, Dan, Wang, David L, Garbers   +2 more
openaire   +2 more sources

Progesterone and CatSper dependency

International Journal of Andrology, 2012
Martin, Blomberg Jensen, Stephen J, Publicover   +1 more
openaire   +2 more sources

A CUG-initiated CATSPERθ functions in the CatSper channel assembly and serves as a checkpoint for flagellar trafficking

Proceedings of the National Academy of Sciences of the United States of America, 2023
Jean-Ju Chung, Riccardo Percudani, Masahito Ikawa   +2 more
exaly  

C2cd6-encoded CatSperτ targets sperm calcium channel to Ca2+ signaling domains in the flagellar membrane

Cell Reports, 2022
Jean-Ju Chung, Masahito Ikawa, Jae Yeon Hwang   +2 more
exaly  

Catspermasome: The matrimony of CatSper and SLCO6C1

Biophysical Journal, 2023
openaire   +1 more source

The role of Hv1 and CatSper channels in sperm activation.

The Journal of physiology, 2011
Elevations of sperm intracellular pH and Ca(2+) regulate sperm motility, chemotaxis, capacitation and the acrosome reaction, and play a vital role in the ability of the sperm cell to reach and fertilise the egg. In human spermatozoa, the flagellar voltage-gated proton channel Hv1 is the main H(+) extrusion pathway that controls sperm intracellular pH ...
Polina V, Lishko, Yuriy, Kirichok
openaire   +1 more source