Andrology, Volume 13, Issue 2, Page 184-201, February 2025.Abstract Background Ion channels are essential for differentiation and maturation of germ cells, and even for fertilization in mammals. Different types of potassium channels have been identified, which are grouped into voltage‐gated channels (Kv), ligand‐gated channels (Kligand), inwardly rectifying channels (Kir), and tandem pore domain channels (K2P).
Ariadna Delgado‐Bermúdez +3 more
wiley +1 more source
The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm
, 2011 In the oviduct, cumulus cells that surround the oocyte release progesterone. In human sperm, progesterone stimulates a Ca(2+) increase by a non-genomic mechanism.
Kaupp, U.B. +15 more
core +1 more source
The antidepressant Sertraline inhibits CatSper Ca2+channels in human sperm
, 2021 STUDY QUESTION: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm? SUMMARY ANSWER: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca2+ channel CatSper and affects human sperm
Rehfeld, Anders +11 more
core +1 more source
Expressão de protamina 1, 2 e Catsper 1 em espermatozóides de garanhões [PDF]
, 2023 A identificação de genes envolvidos na reprodução masculina e a avaliação de suas funções melhoram a compreensão sobre as bases moleculares da espermatogênese, fertilização, qualidade espermática e infertilidade masculina.
Figueiredo, Marília Marcolla de
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Investigation In Vitro Expression of CatSper Sub Fragment followed by Production of Polyclonal Antibody: Potential Candidate for The Next Generation of Non Hormonal Contraceptive [PDF]
Cell Journal, 2012 Objective: CatSper is a voltage-sensitive calcium channel that is specifically expressed in the testis and it has a significant role in sperm performance. CatSper (1-4) ion channel subunit genes, causes sperm cell hyperactivation and male fertility.
Mahboobeh Nazari +4 more
doaj
CatSper and Two-Pore channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
, 2019 CatSper channels (CatSper1-4, nomenclature as agreed by NC-IUPHAR [13]) are putative 6TM, voltage-gated, alkalinization-activated calcium permeant channels that are presumed to assemble as a tetramer of α-like subunits and mediate the current ...
Chung, Jean-Ju +3 more
core +1 more source
Revisiting the action of steroids and triterpenoids on the human sperm Ca2+ channel CatSper
, 2020 The sperm-specific Ca2+ channel CatSper (cation channel of sperm) is vital for male fertility. Contradictory findings have been published on the regulation of human CatSper by the endogenous steroids estradiol, testosterone and hydrocortisone, as well as
Rehfeld, A
core +1 more source
Reproductive Biology and Endocrinology, 2003 Background CatSper1 and CatSper2 are two recently identified channel-like proteins, which show sperm specific expression patterns. Through targeted mutagenesis in the mouse, CatSper1 has been shown to be required for fertility, sperm motility and for ...
Reynolds Lindsey +4 more
doaj
(The) expression of sperm-specific cation channel, CatSper in human spermatozoa
, 2004 의학과/박사[한글] 남성의 생식세포인 정자는 고환에서 정자형성과정을 통하여 생성된다. 그러나 고환에 존재하는 정자는 운동성을 갖지 못하며, 정상적으로 난자를 수정시킬 수 있는 능력, 즉 수정능획득 과정 또한 이루어지지 않은 상태이다. 그 후, 정자는 부고환으로 이동되면서 운동성과 수정능획득 과정을 거치게 된다.
최영진
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The Impact of Cryopreservation on CatSper 2 and Tektin 2 in Human Spermatozoa [PDF]
, 2017 Due to deteriorating quality of spermatozoa after cryopreservation, it became so inevitable to find solutions to maintain its quality so it can fertilize the oocyte.
Alshawa, Eiman Mohammed Saeed
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