Results 91 to 100 of about 2,942 (237)
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Advanced Science, Volume 12, Issue 44, November 27, 2025.The quantitative proteomic and phosphoproteomic profiling reveals dynamic phosphorylation regulation of sperm morphogenesis. Kinase‐substrate phosphorylation network and phosphorylation module analysis, followed by in vivo knockdown and knockout analysis, identify TTBK2 and CSNK1G1 as key regulators of morphogenesis, including head, flagellar, and ...
Tianyu Zhu +25 more
wiley +1 more source
An update on the potential for male contraception : emerging options [PDF]
, 2013 The human population continues to grow and is estimated to rise to 10.1 billion by the end of the century. Therefore, there is still an unmet need for safe and highly effective contraceptive options for both men and women.
Alsaadi, Manal +5 more
core +1 more source
A genetic variant of the sperm-specific SLO3 K+ channel has altered pH and Ca2+ sensitivities [PDF]
, 2017 To fertilize an oocyte, sperm must first undergo capacitation in which the sperm plasma membrane becomes hyperpolarized via activation of potassium (K(+)) channels and resultant K(+) efflux.
Butler, Alice +8 more
core +2 more sources
Molecular Reproduction and Development, Volume 92, Issue 9, September 2025.ABSTRACT The increasing focus on understanding spermatozoa mechanisms in rodents aims to enhance reproductive stability and support conservation efforts, particularly for ecologically significant and declining species like the red‐rumped agouti. We aimed to evaluate the interaction between capacitation media and time, testing BSA concentrations—low (4 ...
Lhara Ricarliany Medeiros de Oliveira +9 more
wiley +1 more source
eLife, 2020 Out of millions of ejaculated sperm, a few reach the fertilization site in mammals. Flagellar Ca2+ signaling nanodomains, organized by multi-subunit CatSper calcium channel complexes, are pivotal for sperm migration in the female tract, implicating ...
Lukas Ded +4 more
doaj +1 more source
Mating system variation and gene expression in the male reproductive tract of Peromyscus mice
Molecular Ecology, Volume 34, Issue 15, August 2025.Abstract Genes involved in reproduction often evolve rapidly at the sequence level due to postcopulatory sexual selection (PCSS) driven by male–male competition and male–female sexual conflict, but the impact of PCSS on gene expression has been under‐explored.
Erin R. Voss, Michael W. Nachman
wiley +1 more source
An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation [PDF]
, 2017 Global transcriptome reprogramming during sper-matogenesis ensures timely expression of factors in each phase of male germ cell differentiation. Sper-matocytes and spermatids require particularly exten-sive reprogramming of gene expression to switch from
Alberdi, Antonio J. +9 more
core +2 more sources
Inhibition of CatSper and Hv1 Channels and NOX5 Enzyme Affect Progesterone-Induced Increase of Intracellular Calcium Concentration and ROS Generation in Human Sperm [PDF]
Iranian Journal of Medical Sciences, 2019 Background: Normal sperm function depends on appropriate intracellular calcium (Cai2+) and reactive oxygen species (ROS) levels. Calcium activates NADPH oxidase-5 (NOX5) that leads to ROS generation. The calcium channel of sperm (CatSper) is activated by
Hamideh Ghanbari +3 more
doaj +1 more source
Cell-penetrating peptides, targeting the regulation of store-operated channels, slow decay of the progesterone-induced [Ca 2+ ] i signal in human sperm [PDF]
, 2015 © 2015 The Authors. Published by Oxford University Press. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1093/molehr ...
Aitken +10 more
core +3 more sources