How exome sequencing improves the diagnostics and management of men with non‐syndromic infertility
Andrology, Volume 13, Issue 5, Page 1011-1024, July 2025.Abstract Male infertility affects approximately 17% of all men and represents a complex disorder in which not only semen parameters such as sperm motility, morphology, and number of sperm are highly variable, but also testicular phenotypes range from normal spermatogenesis to complete absence of germ cells.
Birgit Stallmeyer +2 more
wiley +1 more source
A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm [PDF]
, 2018 Background and Purpose: Sperm from many species share the sperm-specific Ca2+ channel CatSper (cation channel of sperm) that controls the intracellular Ca2+ concentration and, thereby, the swimming behaviour.
Alvarez, Luis +17 more
core +1 more source
The antidepressant Sertraline inhibits CatSper Ca2+channels in human sperm
, 2021 STUDY QUESTION: Do selective serotonin reuptake inhibitor (SSRI) antidepressants affect the function of human sperm? SUMMARY ANSWER: The SSRI antidepressant Sertraline (e.g. Zoloft) inhibits the sperm-specific Ca2+ channel CatSper and affects human sperm
Rehfeld, Anders +11 more
core +1 more source
Revisiting the action of steroids and triterpenoids on the human sperm Ca2+ channel CatSper
, 2020 The sperm-specific Ca2+ channel CatSper (cation channel of sperm) is vital for male fertility. Contradictory findings have been published on the regulation of human CatSper by the endogenous steroids estradiol, testosterone and hydrocortisone, as well as
Rehfeld, A
core +1 more source
Investigation In Vitro Expression of CatSper Sub Fragment followed by Production of Polyclonal Antibody: Potential Candidate for The Next Generation of Non Hormonal Contraceptive [PDF]
Cell Journal, 2012 Objective: CatSper is a voltage-sensitive calcium channel that is specifically expressed in the testis and it has a significant role in sperm performance. CatSper (1-4) ion channel subunit genes, causes sperm cell hyperactivation and male fertility.
Mahboobeh Nazari +4 more
doaj
, 2022 Sperm aktivasyonu ve fertilizasyon yeteneğinin kazanılmasında kalsiyum (Ca+2) iyonu oldukça önemli bir rol oynamaktadır. Catsper kanalları, Ca+2’un hücreye girişini düzenleyen, spermlere özgü voltaj kapılı Ca+2 kanallarıdır.
Kanaan, Zatelimad
core
Eugenol Protection of Testicular Function in Diabetic Rats by Attenuating Oxidative Stress and Restoring CatSper Gene Expression [PDF]
Research in Molecular MedicineBackground: Diabetes mellitus (DM) frequently leads to male infertility, with oxidative stress being a primary culprit in damaging testicular function.
Maryam Shaeghi Rad +4 more
doaj
(The) expression of sperm-specific cation channel, CatSper in human spermatozoa
, 2004 의학과/박사[한글] 남성의 생식세포인 정자는 고환에서 정자형성과정을 통하여 생성된다. 그러나 고환에 존재하는 정자는 운동성을 갖지 못하며, 정상적으로 난자를 수정시킬 수 있는 능력, 즉 수정능획득 과정 또한 이루어지지 않은 상태이다. 그 후, 정자는 부고환으로 이동되면서 운동성과 수정능획득 과정을 거치게 된다.
최영진
core
CCR6 is required for ligand-induced CatSper activation in human sperm
Oncotarget, 2017 CatSper channel has been considered the principal sperm Ca2+ channel responsible for the cytosolic Ca2+ elevation required for various sperm functions necessary for fertilization [1-4]. However, the mechanism underlying the activation of CatSper channel by various physiological ligands remain incompletely understood.
Diao, RY +14 more
openaire +4 more sources
The Impact of Cryopreservation on CatSper 2 and Tektin 2 in Human Spermatozoa [PDF]
, 2017 Due to deteriorating quality of spermatozoa after cryopreservation, it became so inevitable to find solutions to maintain its quality so it can fertilize the oocyte.
Alshawa, Eiman Mohammed Saeed
core +1 more source