Results 31 to 40 of about 1,350 (163)

The CatSper channel: a polymodal chemosensor in human sperm [PDF]

The EMBO Journal, 2012
The sperm-specific CatSper channel controls the intracellular Ca(2+) concentration ([Ca(2+)](i)) and, thereby, the swimming behaviour of sperm. In humans, CatSper is directly activated by progesterone and prostaglandins-female factors that stimulate Ca(2+) influx.
Brenker, C., Goodwin, N., Weyand, I., Kashikar, N., Naruse, M., Krahling, M., Muller, A., Kaupp, U., Strünker, T.   +8 more
openaire   +3 more sources

CatSper: a unique calcium channel of the sperm flagellum [PDF]

Current Opinion in Physiology, 2018
To overcome egg protective vestments and ensure successful fertilization, mammalian spermatozoa switch symmetrical progressive motility to a powerful, whip-like flagellar motion, known as hyperactivation. The latter is triggered by a calcium influx through the sperm-specific, voltage-dependent, and alkalization-activated calcium channel of sperm ...
Lishko, Polina V, Mannowetz, Nadja
openaire   +4 more sources

Conserved Mechanism of Bicarbonate-Induced Sensitization of CatSper Channels in Human and Mouse Sperm

Frontiers in Cell and Developmental Biology, 2021
To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract. A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated by membrane depolarization and intracellular alkalinization.
Juan J. Ferreira, Juan J. Ferreira, Pascale Lybaert, Lis C. Puga-Molina, Celia M. Santi, Celia M. Santi   +5 more
doaj   +1 more source

Up-regulation of CatSper genes family by selenium [PDF]

Reproductive Biology and Endocrinology, 2009
Abstract Background CatSper1-4 are a unique family of sperm cation channels, which are exclusively expressed in the testis and play an important role in sperm motility and male fertility. Despite their vital role in male fertility, almost nothing is known about the factors regulating their expression.
Movahedin Mansoureh, Mohammadi Shabnam, Mowla Seyed   +2 more
openaire   +3 more sources

CatSperβ, a Novel Transmembrane Protein in the CatSper Channel Complex [PDF]

Journal of Biological Chemistry, 2007
Four CatSper ion channel subunit genes (CatSpers 1-4) are required for sperm cell hyperactivation and male fertility. The four proteins assemble (presumably as a tetramer) to form a sperm-specific, alkalinization-activated Ca(2+)-selective channel.
Jin, Liu, Jingsheng, Xia, Kwang-Hyun, Cho, David E, Clapham, Dejian, Ren   +4 more
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Discovery and Characterization of Multiple Classes of Human CatSper Blockers

ChemMedChem, 2022
AbstractThe cation channel of sperm (CatSper) is a validated target for nonhormonal male contraception, but it lacks selective blockers, hindering studies to establish its role in both motility and capacitation. Via an innovative calcium uptake assay utilizing human sperm we discovered novel inhibitors of CatSper function from a high‐throughput ...
Erick J. Carlson, Rawle Francis, Yutong Liu, Ping Li, Maximilian Lyon, Celia M. Santi, Derek J. Hook, Jon E. Hawkinson, Gunda I. Georg   +8 more
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Comparative genomic analysis suggests that the sperm-specific sodium/proton exchanger and soluble adenylyl cyclase are key regulators of CatSper among the Metazoa

Zoological Letters, 2019
Background CatSper is a sperm-specific calcium ion (Ca2+) channel, which regulates sperm flagellar beating by tuning cytoplasmic Ca2+ concentrations. Although this Ca2+ channel is essential for mammalian fertilization, recent bioinformatics analyses have
Francisco Romero, Takuya Nishigaki
doaj   +1 more source

Genetic male infertility and mutation of CATSPER ion channels [PDF]

European Journal of Human Genetics, 2010
A clinically significant proportion of couples experience difficulty in conceiving a child. In about half of these cases male infertility is the cause and often genetic factors are involved. Despite advances in clinical diagnostics ∼50% of male infertility cases remain idiopathic.
Michael S, Hildebrand, Matthew R, Avenarius, Marc, Fellous, Yuzhou, Zhang, Nicole C, Meyer, Jana, Auer, Catherine, Serres, Kimia, Kahrizi, Hossein, Najmabadi, Jacques S, Beckmann, Richard J H, Smith   +10 more
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The CatSper channel controls chemosensation in sea urchin sperm [PDF]

The EMBO Journal, 2014
Sperm guidance is controlled by chemical and physical cues. In many species, Ca(2+) bursts in the flagellum govern navigation to the egg. In Arbacia punctulata, a model system of sperm chemotaxis, a cGMP signaling pathway controls these Ca(2+) bursts. The underlying Ca(2+) channel and its mechanisms of activation are unknown.
Seifert, R., Flick, M., Bönigk, W., Alvarez, L., Trötschel, C., Poetsch, A., Müller, A., Goodwin, N., Pelzer, P., Kashikar, N.D., Kremmer, E., Jikeli, J., Timmermann, B., Kuhl, H., Fridman, D., Windler, F., Kaupp, U.B., Strünker, T.   +17 more
openaire   +5 more sources

SKF96365 modulates activity of CatSper channels in human sperm

Molecular Human Reproduction, 2023
Abstract Exposure of human sperm to progesterone (P4) activates cation channel of sperm (CatSper) channels, inducing an intracellular Ca2+ concentration ([Ca2+]i) transient followed by repetitive [Ca2+]i activity (oscillations), which are believed to be functionally important.
Elis Torrezan-Nitao, Sean G Brown, Linda Lefievre, Jennifer Morris, Joao Correia, Claire V Harper, Stephen Publicover   +6 more
openaire   +3 more sources