Results 31 to 40 of about 1,915 (186)

Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. [PDF]

PLoS ONE, 2008
The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated Ca2+ channels that are crucial for sperm hyperactivation and male fertility. All four CatSper subunits are believed to assemble into a heteromultimeric channel complex,
Xinjiang Cai, David E Clapham
doaj   +1 more source

CatSper channels are regulated by protein kinase A [PDF]

Journal of Biological Chemistry, 2018
Mammalian sperm must undergo capacitation as a preparation for entering into hyperactivated motility, undergoing the acrosome reaction, and acquiring fertilizing ability. One of the initial capacitation events occurs when sperm encounter an elevated HCO3- concentration.
Gerardo Orta, José Luis de la Vega-Beltran, David Martín-Hidalgo, Celia M. Santi, Pablo E. Visconti, Alberto Darszon   +5 more
openaire   +3 more sources

Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm

Frontiers in Endocrinology, 2020
Aim: Evidence suggests that bisphenol A diglycidyl ether (BADGE), bisphenol A (BPA), and BPA analogs can interfere with human male fertility. However, the effect directly on human sperm function is not known.
Anders Rehfeld, Anders Rehfeld, A. M. Andersson, A. M. Andersson, N. E. Skakkebæk, N. E. Skakkebæk   +5 more
doaj   +1 more source

Pharmacological Inactivation of CatSper Blocks Sperm Fertilizing Ability Independently of the Capacitation Status of the Cells: Implications for Non-hormonal Contraception

Frontiers in Cell and Developmental Biology, 2021
Cation channel of sperm (CatSper), the main sperm-specific Ca2+ channel, plays a key role in mammalian fertilization, and it is essential for male fertility, becoming an attractive target for contraception.
Ludmila Curci, Guillermo Carvajal, Valeria Sulzyk, Soledad Natalia Gonzalez, Patricia S. Cuasnicú   +4 more
doaj   +1 more source

The Cation/Calcium Channel of Sperm (CatSper): A Common Role Played Despite Inter-Species Variation?

, 2023
The main cation/calcium channel of spermatozoa (CatSper), first identified in 2001, has been thoroughly studied to elucidate its composition and function, while its distribution among species and sperm sources is yet incomplete.
Rodriguez-Martinez, Heriberto, Álvarez Rodríguez, Manuel, Alejandro Vicente-Carrillo, Heriberto Rodriguez-Martinez, Álvarez-Rodríguez, Manuel, Rodriguez-Martinez, Heriberto,, Vicente-Carrillo, Alejandro, Vicente-Carrillo, Alejandro,, Alvarez-Rodriguez, Manuel,, Manuel Álvarez-Rodríguez, Rodríguez Martínez, Heriberto, Vicente Carrillo, Alejandro   +11 more
core   +1 more source

Competitive CatSper Activators of Progesterone from Rhynchosia volubilis [PDF]

Planta Medica, 2021
AbstractThe root Rhynchosia volubilis was widely used for contraception in folk medicine, although its molecular mechanism on antifertility has not yet been revealed. In human sperm, it was reported that the cation channel of sperm, an indispensable cation channel for the fertilization process, could be regulated by various steroid-like compounds in ...
Xiang, Jin, Kang, Hang, Li, Hong-Gang, Shi, Yu-Long, Zhang, Ya-Li, Ruan, Chang-Lei, Liu, Lin-Hui, Gao, Han-Qi, Luo, Tao, Hu, Gao-Sheng, Zhu, Wei-Liang, Jia, Jing-Ming, Chen, Jia-Chun, Fang, Jin-Bo   +13 more
openaire   +2 more sources

A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm [PDF]

, 2018
BACKGROUND AND PURPOSE Sperm from many species share the sperm-specific Ca2+ channel CatSper that controls the intracellular Ca2+ concentration and, thereby, the swimming behaviour.
Wachten, D., Rennhack, A., Schiffer, C., Brenker, C., Fridman, D., Kierzek, M., Struenker, T., Tamburrino, L, Cheng, Y., Balbach, M., Tamburrino, L., Alvarez, L., Publicover, S., Baldi, E., Berger, T., Stoelting, G., Kaupp, U., Baldi, E, Nitao, E., Zeng, X.   +19 more
core   +2 more sources

Conservation of the Ca2+-permeability through the voltage sensor domain of mammalian CatSper subunit

Channels, 2018
Cation channel of Spermatozoa (CatSper) is one of the voltage-gated ion channels consisting of voltage sensor domains (VSDs) and pore-gate domains. CatSper is exclusively expressed in spermatozoa and indispensable for Ca2+ influx into cytosol.
Hiroki Arima, Hidekazu Tsutsui, Yasushi Okamura   +2 more
doaj   +1 more source

Up-regulation of CatSper genes family by selenium [PDF]

Reproductive Biology and Endocrinology, 2009
Abstract Background CatSper1-4 are a unique family of sperm cation channels, which are exclusively expressed in the testis and play an important role in sperm motility and male fertility. Despite their vital role in male fertility, almost nothing is known about the factors regulating their expression.
Movahedin Mansoureh, Mohammadi Shabnam, Mowla Seyed   +2 more
openaire   +3 more sources

Study the role of KSper current for controlling the Ca2+ influx and intracellular pHi in mouse spermatozoa by dominating membrane potentials [PDF]

Iraqi Journal of Veterinary Sciences, 2022
This work was aimed to explore the details of the ion channels gating and there physiological role in sperm in the future.Mouse spermatozoa express a pH-dependent K+ current (KSper) thought to induce hyperpolarization to enhance Ca2+ influx via alkaline ...
Suha Alghazal
doaj   +1 more source