SPINK3-Sperm Interaction Determines a Stable Sperm Subpopulation With Intact CatSper Channel. [PDF]
J Cell PhysiolNicolli AR +10 more
europepmc +3 more sources
Network model predicts that CatSper is the main Ca2+ channel in the regulation of sea urchin sperm motility [PDF]
Scientific Reports, 2017 Spermatozoa sea urchin swimming behaviour is regulated by small peptides from the egg outer envelope. Speract, such a peptide, after binding to its receptor in Strongylocentrotus purpuratus sperm flagella, triggers a signaling pathway that culminates ...
Jesús Espinal-Enríquez +4 more
doaj +2 more sources
The Expression of Kisspeptin Receptor, Catsper 3 and Acrosome Integrity in Oligozoospermic and Normozoospermic Individuals. [PDF]
Genes (Basel)Ünlükal N +5 more
europepmc +3 more sources
Competitive CatSper Activators of Progesterone from Rhynchosia volubilis [PDF]
Planta Medica, 2021 AbstractThe root Rhynchosia volubilis was widely used for contraception in folk medicine, although its molecular mechanism on antifertility has not yet been revealed. In human sperm, it was reported that the cation channel of sperm, an indispensable cation channel for the fertilization process, could be regulated by various steroid-like compounds in ...
Xiang, Jin +13 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2021 The sperm-specific Ca2+ channel CatSper registers chemical cues that assist human sperm to fertilize the egg. Prime examples are progesterone and prostaglandin E1 that activate CatSper without involving classical nuclear and G protein-coupled receptors ...
Janice K. Jeschke +15 more
doaj +1 more source
Cells, 2021 Males have evolved species-specifical sperm morphology and swimming patterns to adapt to different fertilization environments. In eutherians, only a small fraction of the sperm overcome the diverse obstacles in the female reproductive tract and ...
Jae Yeon Hwang +3 more
doaj +1 more source
Down-regulation of CatSper 1 and CatSper 2 genes by lead and mercury [PDF]
Environmental Toxicology and Pharmacology, 2018 In the study of the expression of CatSper genes, consideration of the effects of environmental metal toxicity is very important. Therefore, in this study, the effects of lead acetate and mercury chloride exposure on expression of CatSper genes, sperm parameters, histology of testis and prooxidant antioxidant balance (PAB) values of serum were ...
Mohammadi, S +18 more
openaire +2 more sources
Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta. [PDF]
PLoS ONE, 2008 The mammalian CatSper ion channel family consists of four sperm-specific voltage-gated Ca2+ channels that are crucial for sperm hyperactivation and male fertility. All four CatSper subunits are believed to assemble into a heteromultimeric channel complex,
Xinjiang Cai, David E Clapham
doaj +1 more source
Modular analysis of the control of flagellar Ca2+-spike trains produced by CatSper and CaV channels in sea urchin sperm [PDF]
, 2020 Intracellular calcium ([Ca2+]i) is a basic and ubiquitous cellular signal controlling a wide variety of biological processes. A remarkable example is the steering of sea urchin spermatozoa towards the conspecific egg by a spatially and temporally ...
Carneiro, Jorge +6 more
core +2 more sources
Frontiers in Endocrinology, 2020 Aim: Evidence suggests that bisphenol A diglycidyl ether (BADGE), bisphenol A (BPA), and BPA analogs can interfere with human male fertility. However, the effect directly on human sperm function is not known.
Anders Rehfeld +5 more
doaj +1 more source