Results 31 to 40 of about 1,728 (186)

Bisphenol A Diglycidyl Ether (BADGE) and Bisphenol Analogs, but Not Bisphenol A (BPA), Activate the CatSper Ca2+ Channel in Human Sperm

Frontiers in Endocrinology, 2020
Aim: Evidence suggests that bisphenol A diglycidyl ether (BADGE), bisphenol A (BPA), and BPA analogs can interfere with human male fertility. However, the effect directly on human sperm function is not known.
Anders Rehfeld, Anders Rehfeld, A. M. Andersson, A. M. Andersson, N. E. Skakkebæk, N. E. Skakkebæk   +5 more
doaj   +1 more source

Pharmacological Inactivation of CatSper Blocks Sperm Fertilizing Ability Independently of the Capacitation Status of the Cells: Implications for Non-hormonal Contraception

Frontiers in Cell and Developmental Biology, 2021
Cation channel of sperm (CatSper), the main sperm-specific Ca2+ channel, plays a key role in mammalian fertilization, and it is essential for male fertility, becoming an attractive target for contraception.
Ludmila Curci, Guillermo Carvajal, Valeria Sulzyk, Soledad Natalia Gonzalez, Patricia S. Cuasnicú   +4 more
doaj   +1 more source

Competitive CatSper Activators of Progesterone from Rhynchosia volubilis [PDF]

Planta Medica, 2021
AbstractThe root Rhynchosia volubilis was widely used for contraception in folk medicine, although its molecular mechanism on antifertility has not yet been revealed. In human sperm, it was reported that the cation channel of sperm, an indispensable cation channel for the fertilization process, could be regulated by various steroid-like compounds in ...
Xiang, Jin, Kang, Hang, Li, Hong-Gang, Shi, Yu-Long, Zhang, Ya-Li, Ruan, Chang-Lei, Liu, Lin-Hui, Gao, Han-Qi, Luo, Tao, Hu, Gao-Sheng, Zhu, Wei-Liang, Jia, Jing-Ming, Chen, Jia-Chun, Fang, Jin-Bo   +13 more
openaire   +2 more sources

The Cation/Calcium Channel of Sperm (CatSper): A Common Role Played Despite Inter-Species Variation?

, 2023
The main cation/calcium channel of spermatozoa (CatSper), first identified in 2001, has been thoroughly studied to elucidate its composition and function, while its distribution among species and sperm sources is yet incomplete.
Rodriguez-Martinez, Heriberto, Álvarez Rodríguez, Manuel, Alejandro Vicente-Carrillo, Heriberto Rodriguez-Martinez, Álvarez-Rodríguez, Manuel, Rodriguez-Martinez, Heriberto,, Vicente-Carrillo, Alejandro, Vicente-Carrillo, Alejandro,, Alvarez-Rodriguez, Manuel,, Manuel Álvarez-Rodríguez, Rodríguez Martínez, Heriberto, Vicente Carrillo, Alejandro   +11 more
core   +1 more source

Study the role of KSper current for controlling the Ca2+ influx and intracellular pHi in mouse spermatozoa by dominating membrane potentials [PDF]

Iraqi Journal of Veterinary Sciences, 2022
This work was aimed to explore the details of the ion channels gating and there physiological role in sperm in the future.Mouse spermatozoa express a pH-dependent K+ current (KSper) thought to induce hyperpolarization to enhance Ca2+ influx via alkaline ...
Suha Alghazal
doaj   +1 more source

CatSper and Two-Pore channels (TPC) in GtoPdb v.2022.1

, 2022
CatSper channels (CatSper1-4, nomenclature as agreed by NC-IUPHAR [14]) are putative 6TM, voltage-gated, alkalinization-activated calcium permeant channels that are presumed to assemble as a tetramer of α-like subunits and mediate the current ...
Chung, Jean-Ju, Grimm, Christian M., Ren, Dejian, Clapham, David E., Garbers, David L.   +4 more
core   +1 more source

Genomic identification, expression profiling, and functional characterization of CatSper channels in the bovine† [PDF]

, 2017
Cation channels of sperm (CatSper) are sperm-specific calcium channels with identified roles in the regulation of sperm function in humans, mice, and horses.
Hoey, David A., David A. Hoey, Anne-Marie English (5141153), Kieran G. Meade (11583287), English, Anne-Marie, Sinéad Cronin (12590035), David A. Hoey (11605833), Sinead Cronin, Kieran G. Meade, Fair, Sean, Johnson, Gillian P., Cronin, Sinead, Anne-Marie English, Sean Fair, Gillian P. Johnson (12579532), Seán Fair (5141156), Meade, Kieran G., Gillian P. Johnson   +17 more
core   +2 more sources

Conserved Mechanism of Bicarbonate-Induced Sensitization of CatSper Channels in Human and Mouse Sperm

Frontiers in Cell and Developmental Biology, 2021
To fertilize an egg, mammalian sperm must undergo capacitation in the female genital tract. A key contributor to capacitation is the calcium (Ca2+) channel CatSper, which is activated by membrane depolarization and intracellular alkalinization.
Juan J. Ferreira, Juan J. Ferreira, Pascale Lybaert, Lis C. Puga-Molina, Celia M. Santi, Celia M. Santi   +5 more
doaj   +1 more source

A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm [PDF]

, 2018
BACKGROUND AND PURPOSE Sperm from many species share the sperm-specific Ca2+ channel CatSper that controls the intracellular Ca2+ concentration and, thereby, the swimming behaviour.
Wachten, D., Rennhack, A., Schiffer, C., Brenker, C., Fridman, D., Kierzek, M., Struenker, T., Tamburrino, L, Cheng, Y., Balbach, M., Tamburrino, L., Alvarez, L., Publicover, S., Baldi, E., Berger, T., Stoelting, G., Kaupp, U., Baldi, E, Nitao, E., Zeng, X.   +19 more
core   +2 more sources

Up-regulation of CatSper genes family by selenium [PDF]

Reproductive Biology and Endocrinology, 2009
Abstract Background CatSper1-4 are a unique family of sperm cation channels, which are exclusively expressed in the testis and play an important role in sperm motility and male fertility. Despite their vital role in male fertility, almost nothing is known about the factors regulating their expression.
Movahedin Mansoureh, Mohammadi Shabnam, Mowla Seyed   +2 more
openaire   +3 more sources