Results 101 to 110 of about 147,390 (303)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Radiated energy fraction of SPI-induced disruptions at ASDEX Upgrade

Nuclear Fusion
Future large tokamaks will operate at high plasma currents and high stored plasma energies. To ensure machine protection in case of a sudden loss of plasma confinement (major disruption), a large fraction of the magnetic and thermal energy must be ...
P. Heinrich, G. Papp, S. Jachmich, J. Artola, M. Bernert, P. de Marné, M. Dibon, R. Dux, T. Eberl, J. Hobirk, M. Lehnen, T. Peherstorfer, N. Schwarz, U. Sheikh, B. Sieglin, J. Svoboda, the ASDEX Upgrade Team, the EUROfusion Tokamak Exploitation Team   +17 more
doaj   +1 more source

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source

Canada in a Climate Disrupted World [PDF]

, 2017
Climate change has already begun impacting economies and societies across the globe, and its impacts are expected to increase into the future. Adaptation to climate change is and will continue to be one of the greatest policy challenges facing the ...
Dalby, Simon, Dasilva, Clay, Scott, Daniel, Suen, Alex   +3 more
core   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

First operation of a dedicated runaway electron mitigation coil (REMC)

Nuclear Fusion
We report observations from the first experimental tests of a dedicated runaway electron mitigation coil (REMC) installed inside a tokamak’s vacuum vessel and driven by the disruption loop voltage.
Jeffrey P. Levesque, Anson E. Braun, Nigel J. DaSilva, Matthew N. Notis, Christopher J. Hansen, Michael E. Mauel, Gerald A. Navratil, Carlos A. Paz-Soldan   +7 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

A Climate of Disorder: What to do About the Obstacles to Effective Climate Politics [PDF]

, 2016
The emphasis on general distributive principles in the climate justice literature has left significant gaps regarding the problem of weak climate governance.
Maltais, Aaron
core  

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Runaway electron mitigation by 3D fields application in ASDEX Upgrade, COMPASS, and RFX-mod

Frontiers in Physics
Disruption-generated runaway electron (RE) beams represent a potentially severe threat for tokamak plasma-facing components. Application of properly designed 3D fields can act as a mitigation mechanism, as recently investigated in ASDEX Upgrade (AUG) and
M. Gobbin, M. Valisa, L. Marrelli, G. Papp, G. Pautasso, E. Tomesova, T. Markovic, O. Ficker, J. Cerovsky, Y. Liu, L. Li   +10 more
doaj   +1 more source