Results 91 to 100 of about 147,390 (303)

Financial impact of cost of capital on tourism-based SMEs in COVID-19: implications for tourism disruption mitigation. [PDF]

Environ Sci Pollut Res Int, 2023
Song Y, Yan J, Yu Z, Li T, Yang Y.
europepmc   +1 more source

Disruption runaway electron generation and mitigation in the Spherical Tokamak for Energy Production (STEP)

Nuclear Fusion
Generation of Runaway Electrons (REs) during plasma disruptions is of great concern for ITER and future reactors based on the tokamak concept. Unmitigated RE generation in the current STEP (Spherical Tokamak for Energy Production) concept design is ...
A. Fil, L. Henden, S. Newton, M. Hoppe, O. Vallhagen   +4 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A multi-stage supply chain disruption mitigation strategy considering product life cycle during COVID-19. [PDF]

Environ Sci Pollut Res Int, 2022
Chen J, Wang H, Fu Y.
europepmc   +1 more source

Runaway electron dynamics in ITER disruptions with shattered pellet injections

Nuclear Fusion
This study systematically explores the parameter space of disruption mitigation through shattered pellet injection in ITER with a focus on runaway electron (RE) dynamics, using the disruption modeling tool Dream .
O. Vallhagen, L. Hanebring, F.J. Artola, M. Lehnen, E. Nardon, T. Fülöp, M. Hoppe, S.L. Newton, I. Pusztai   +8 more
doaj   +1 more source

Supply Chain Disruption Models: A Critical Review

Logistics Research, 2018
Enterprises affected by supply chain disruptions have reported adverse consequences and dramatic financial losses. Within the research area of supply chain risk management, researchers use simulation models and algorithms to analyze disruption risks ...
Niels Bugert, Rainer Lasch
doaj   +1 more source

Determining The Cost Effectiveness Of Solutions To Diffuse Pollution: Developing A Model To Assess In-Field Mitigation Options for Phosphorous and Sediment Loss [PDF]

The European Union Water Framework Directive requires governments to set water quality objectives based on good ecological status. This includes specific requirements to control diffuse pollution. Diffuse phosphorous (P) pollution plays a pivotal role in
Bailey, Alison P., Jackson, Bob, Quinton, John, Silgram, Martyn, Stevens, Carly   +4 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Impact of breech geometry and propellant flow on the release of large pellets for the ITER disruption mitigation system

Nuclear Fusion
Studies have been performed on the release mechanism for large pellets using high pressure gas in a shattered pellet injector. Typically, pellets are dislodged from the cryogenic surface and accelerated down a barrel using high pressure gas delivered by ...
T.E. Gebhart, L.R. Baylor, M. Dibon, M.N. Ericson, E.J. Felske, S.S. Frank, W.L. Gardner, A.G. Ghiozzi, S. Jachmich, U. Kruezi, M. Lehnen, D.A. Velez   +11 more
doaj   +1 more source