Results 71 to 80 of about 147,390 (303)

Simulation of DIII-D disruption with argon pellet injection and runaway electron beam

Nuclear Fusion
The next generation of large tokamaks, including ITER, will be equipped with a disruption mitigation system (DMS) that can be activated if a disruption is deemed to be imminent.
C. Zhao, C. Liu, S.C. Jardin, N.M. Ferraro, B.C. Lyons   +4 more
doaj   +1 more source

The Global Risks Report 2016, 11th Edition [PDF]

, 2016
Now in its 11th edition, The Global Risks Report 2016 draws attention to ways that global risks could evolve and interact in the next decade. The year 2016 marks a forceful departure from past findings, as the risks about which the Report has been ...

core  

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Impact of impurity seeding on shattered pellet injection mitigations on the Joint European Torus

Nuclear Fusion
Plasma disruptions present a significant challenge to the viability of fusion energy production in tokamak reactors. Among disruption mitigation techniques, shattered pellet injection (SPI) has emerged as a promising approach.
U. Sheikh, S. Jachmich, M. Kong, G. Bodner, N. Eidietis, O. Ficker, M. Lehnen, C. Reux, B. Stein-Lubrano, J. Svoboda, JET Contributors, the EUROfusion Tokamak Exploitation Team   +11 more
doaj   +1 more source

Cost Consequences of a Port-Related Supply Chain Disruption

Asian Journal of Shipping and Logistics, 2015
Port functionality is a significant and important aspect of cargo transportation. Previous studies have identified a list of port-related supply chain disruption threats and developed a management model that seeks to address these threats.
Hui Shan LOH, Vinh Van THAI
doaj   +1 more source

Benefit-Cost Analysis of FEMA Hazard Mitigation Grants [PDF]

Mitigation ameliorates the impact of natural hazards on communities by reducing loss of life and injury, property and environmental damage, and social and economic disruption.
Adam Rose, Anne S. Kiremidjian, Carol Taylor West, Charles Huyck, Craig Taylor, David Godschalk, Douglass Shaw, Jawhar Bouabid, John C. Whitehead, Kathleen, Keith Porter, L. Thomas Tobin, Nicole Dash, Philip T. Ganderton, Ronald T. Eguchi, Thomas R. McLane   +15 more
core  

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Measuring information security breach impact and uncertainties under various information sharing scenarios [PDF]

, 2013
This study draws on information theory and aims to provide simulated evidence using real historical and statistical data to demonstrate how various levels of integration moderate the impact and uncertainties of information security breach on supply chain
Chan, Hing, Durowoju, Olatunde, Wang, Xiaojun   +2 more
core  

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Disruption mitigation modeling for the SPARC tokamak

Physics of Plasmas
Two primary systems planned for disruption mitigation in the SPARC tokamak, massive gas injection (MGI), and the runaway electron mitigation coil (REMC), are modeled with the 3D MHD code NIMROD. MGI is modeled in four configurations, and each of the 6-valve and 4-valve configurations considered is predicted to produce a high radiation fraction (>
V. A. Izzo, B. Stein-Lubrano, A. Battey, R. Sweeney, C. Hansen, R. A. Tinguely   +5 more
openaire   +1 more source