Results 61 to 70 of about 147,390 (303)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Multi-device analysis of energy loss duration and pellet penetration with implications for shattered pellet injection in ITER

Nuclear Fusion
A robust disruption mitigation system (DMS) requires accurate characterization of key disruption timescales, one of the most notable being the thermal quench (TQ).
G. Bodner, N. Eidietis, Z. Chen, P. Heinrich, J. Herfindal, S. Jachmich, G. Papp, J. Kim, M. Lehnen, U. Sheikh, I. Coffey, O. Ficker, S. Gerasimov, V. Kachkanov, C. Reux, S. Silburn, H. Sun, the ASDEX Upgrade Team, JET Contributors, the EUROfusion Tokamak Exploitation Team   +19 more
doaj   +1 more source

Pressure Wave Propagation Optimization Models for Supply Chain Risk Mitigation

Systems
Supply chain (SC) disruption risk assessment and mitigation have attracted significant attention in both academia and practice. However, existing research predominantly focuses on unidirectional disruption propagation, either forward or backward, despite
Ming Liu, Jiawei Zhang, Yueyu Ding
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Quantitative Model of Supply Chain Disruption Propagation Dynamics

Engineering Proceedings
Supply chain disruptions caused by natural disasters and human-made incidents have inflicted substantial losses on numerous companies. The management of supply chain risks, including disruption risk, has garnered significant attention from both academia ...
Shudong Liu, Shili Xiang, Lu Wang
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Variability of MHD instabilities in benign termination of high-current runaway electron beams in the JET and DIII-D tokamaks

Nuclear Fusion
Benign termination, in which magnetohydrodynamic (MHD) instabilities deconfine runaway electrons (REs) following hydrogenic injections, is a promising strategy for mitigating dangerous RE loads after disruptions.
C.F.B. Zimmermann, C. Paz-Soldan, G. Su, C. Reux, A.F. Battey, O. Ficker, S.N. Gerasimov, C.J. Hansen, S. Jachmich, A. Lvovskiy, J. Puchmayr, N. Schoonheere, U. Sheikh, I.G. Stewart, G. Szepesi, JET Contributors, the EUROfusion Tokamak Exploitation Team   +16 more
doaj   +1 more source

Scenarios as the basis for assessment of mitigation and adaptation [PDF]

, 2010
The possibilities and need for adaptation and mitigation depends on uncertain future developments with respect to socio-economic factors and the climate system. Scenarios are used to explore the impacts of different strategies under uncertainty.
Arnell, Nigel, Barker, T, Bauer, N, Berkhout, F, Criqui, P, Hilderink, H, Hinkel, J, Hof, A, Isaac, M., Kitous, A, Kram, T, Kundzewicz, Z., Mechler, R, Scrieciu, S, van Vuuren, D. P.   +14 more
core  

Feedback control of the National Airspace System to mitigate weather disruptions [PDF]

49th IEEE Conference on Decision and Control (CDC), 2010
This paper proposes a general modeling framework adapted to the feedback control of traffic flows in Eulerian models of the National Airspace System (NAS). It is shown that the problems of scheduling and routing aircraft flows in the NAS can be posed as the control of a network of queues with load-dependent service rates.
Jerome Le Ny, Hamsa Balakrishnan
openaire   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source