Results 41 to 50 of about 147,390 (303)

Identifying Risks and Mitigating Disruptions in the Automotive Supply Chain [PDF]

Interfaces, 2015
Firms are exposed to a variety of low-probability, high-impact risks that can disrupt their operations and supply chains. These risks are difficult to predict and quantify; therefore, they are difficult to manage. As a result, managers may suboptimally deploy countermeasures, leaving their firms exposed to some risks, while wasting resources to ...
David Simchi-Levi, William Schmidt, Yehua Wei, Peter Yun Zhang, Keith Combs, Yao Ge, Oleg Gusikhin, Michael Sanders, Don Zhang   +8 more
openaire   +3 more sources

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source

Effects on characteristics of plasma disruption mitigation using shattered pellet injection with different shatter tubes on EAST

Nuclear Fusion
Plasma disruptions present considerable risks to tokamak devices, necessitating the implementation of advanced mitigation techniques such as shattered pellet injection (SPI). This study examines the influence of various shatter tube designs on disruption
L. Li, J.S. Yuan, S.B. Zhao, Y.M. Duan, H.D. Zhuang, D.L. Chen, A. Ti, W. Xia, S.T. Mao, F.D. Wang, T.H. Shi, J.H. Yang, B. Zhang, M. Huang, Y. Chen, G.Z. Zuo, J.S. Hu   +16 more
doaj   +1 more source

Climate Change Reporting: A Resource Based Perspective [PDF]

, 2011
Kajian ini dilakukan untuk mengkaji tahap serta faktor yang mengalakkan laporan pemanasan global di antara syarikat-syarikat yang tersenarai di Bursa Malaysia.
Shaikh Salim, Siti Zulaikha
core  

Mitigation of the Environmental Disruption due to the Disaster

Journal of the Japan Society of Engineering Geology, 2007
災害による環境破壊が, 世界中で幾度となく起こっている. これらの災害としては, 人為災害と自然災害があり, 環境破壊としては, 社会環境の破壊と自然環境の破壊がある. 従来から, 災害からの人的・物的被害の軽減は, 応用地質の大きなテーマの一つであるが, 災害による環境破壊という観点での研究は少ない. ここでは, 著者らは地質に密接に関連した人為災害の一つである鉄穴流しに注目し, 山地部での森林破壊・土壌浸食と平野部での土砂の氾濫や天井川の築堤などの事例研究を行った.次に, 自然災害では火山噴火や地震・豪雨などによる社会環境や自然環境の破壊があり, ここでは, 2000年三宅島噴火による森林破壊と, 2004年新潟県中越地震での山古志地区の森林被害や天然ダム ...
Hideki INAGAKI, Hiroyuki OHNO
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Micro-particle injection experiments in ADITYA-U tokamak using an inductively driven pellet injector

Nuclear Fusion
A first-of-its-kind, inductively driven micro-particle (Pellet) accelerator and injector have been developed and operated successfully in ADITYA-U circular plasma operations, which may ably address the critical need for a suitable disruption control ...
Sambaran Pahari, Rahulnath P.P., Aditya Nandan Savita, Pradeep Kumar Maurya, Saroj Kumar Jha, Neeraj Shiv, Raghavendra K., Harsh Hemani, Belli Nagaraju, Sukantam Mahar, Manmadha Rao, I.V.V. Suryaprasad, U.D. Malshe, J. Ghosh, B.R. Doshi, Prabal Kumar Chattopadhyay, R.L. Tanna, K.A. Jadeja, K.M. Patel, Rohit Kumar, Tanmay Macwan, Harshita Raj, S. Aich, Kaushlender Singh, Suman Dolui, D. Kumawat, M.N. Makwana, K.S. Shah, Shivam Gupta, V. Balakrishnan, C.N. Gupta, Swadesh Kumar Patnaik, Praveenlal Edappala, Minsha Shah, Bhavesh Kadia, Nandini Yadava, Kajal Shah, G. Shukla, M.B. Chowdhuri, R. Manchanda, Nilam Ramaiya, Manoj Kumar, Umesh Nagora, Varsha S., S.K. Pathak, Kumudni Asudani, Paritosh Chaudhuri, P.N. Maya, Rajiv Goswami, A. Sen, Y.C. Saxena, R. Pal, S. Chaturvedi   +52 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Resilient Supply Chain Optimization Considering Alternative Supplier Selection and Temporary Distribution Center Location

Mathematics, 2023
The global supply chain is facing huge uncertainties due to potential emergencies, and the disruption of any link may threaten the security of the supply chain. This paper considers a disruption scenario in which supply disruption and distribution center
Na Wang, Jingze Chen, Hongfeng Wang
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source