Results 41 to 50 of about 32,803 (265)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Variability of MHD instabilities in benign termination of high-current runaway electron beams in the JET and DIII-D tokamaks

Nuclear Fusion
Benign termination, in which magnetohydrodynamic (MHD) instabilities deconfine runaway electrons (REs) following hydrogenic injections, is a promising strategy for mitigating dangerous RE loads after disruptions.
C.F.B. Zimmermann, C. Paz-Soldan, G. Su, C. Reux, A.F. Battey, O. Ficker, S.N. Gerasimov, C.J. Hansen, S. Jachmich, A. Lvovskiy, J. Puchmayr, N. Schoonheere, U. Sheikh, I.G. Stewart, G. Szepesi, JET Contributors, the EUROfusion Tokamak Exploitation Team   +16 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Effects on characteristics of plasma disruption mitigation using shattered pellet injection with different shatter tubes on EAST

Nuclear Fusion
Plasma disruptions present considerable risks to tokamak devices, necessitating the implementation of advanced mitigation techniques such as shattered pellet injection (SPI). This study examines the influence of various shatter tube designs on disruption
L. Li, J.S. Yuan, S.B. Zhao, Y.M. Duan, H.D. Zhuang, D.L. Chen, A. Ti, W. Xia, S.T. Mao, F.D. Wang, T.H. Shi, J.H. Yang, B. Zhang, M. Huang, Y. Chen, G.Z. Zuo, J.S. Hu   +16 more
doaj   +1 more source

TOKES studies of the thermal quench heat load reduction in mitigated ITER disruptions

Nuclear Materials and Energy, 2017
Disruption mitigation by massive gas injection (MGI) of Ne gas has been simulated using the 3D TOKES code that includes the injectors of the Disruption Mitigation System (DMS) as it will be implemented in ITER.
S. Pestchanyi, M. Lehnen, R.A. Pitts, G. Saibene   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Micro-particle injection experiments in ADITYA-U tokamak using an inductively driven pellet injector

Nuclear Fusion
A first-of-its-kind, inductively driven micro-particle (Pellet) accelerator and injector have been developed and operated successfully in ADITYA-U circular plasma operations, which may ably address the critical need for a suitable disruption control ...
Sambaran Pahari, Rahulnath P.P., Aditya Nandan Savita, Pradeep Kumar Maurya, Saroj Kumar Jha, Neeraj Shiv, Raghavendra K., Harsh Hemani, Belli Nagaraju, Sukantam Mahar, Manmadha Rao, I.V.V. Suryaprasad, U.D. Malshe, J. Ghosh, B.R. Doshi, Prabal Kumar Chattopadhyay, R.L. Tanna, K.A. Jadeja, K.M. Patel, Rohit Kumar, Tanmay Macwan, Harshita Raj, S. Aich, Kaushlender Singh, Suman Dolui, D. Kumawat, M.N. Makwana, K.S. Shah, Shivam Gupta, V. Balakrishnan, C.N. Gupta, Swadesh Kumar Patnaik, Praveenlal Edappala, Minsha Shah, Bhavesh Kadia, Nandini Yadava, Kajal Shah, G. Shukla, M.B. Chowdhuri, R. Manchanda, Nilam Ramaiya, Manoj Kumar, Umesh Nagora, Varsha S., S.K. Pathak, Kumudni Asudani, Paritosh Chaudhuri, P.N. Maya, Rajiv Goswami, A. Sen, Y.C. Saxena, R. Pal, S. Chaturvedi   +52 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Pressure Wave Propagation Optimization Models for Supply Chain Risk Mitigation

Systems
Supply chain (SC) disruption risk assessment and mitigation have attracted significant attention in both academia and practice. However, existing research predominantly focuses on unidirectional disruption propagation, either forward or backward, despite
Ming Liu, Jiawei Zhang, Yueyu Ding
doaj   +1 more source

Recent Advances in Multi-Dimensional Vibration Mitigation Materials and Devices

Frontiers in Materials, 2019
Harmful vibrations can cause many engineering problems, such as disasters of civil engineering structures, failure of precision equipment, and the disruption of some spacecraft components.
Zhao-Dong Xu, Zheng-Han Chen, Xing-Huai Huang, Chen-Yu Zhou, Zhong-Wei Hu, Qi-Hang Yang, Pan-Pan Gai   +6 more
doaj   +1 more source