Results 51 to 60 of about 32,803 (265)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Plasmoid drift and first wall heat deposition during ITER H-mode dual-SPIs in JOREK simulations

Nuclear Fusion
The heat flux mitigation during the thermal quench (TQ) by the shattered pellet injection (SPI) is one of the major elements of disruption mitigation strategy for ITER.
D. Hu, F.J. Artola, E. Nardon, M. Lehnen, M. Kong, D. Bonfiglio, M. Hoelzl, G.T.A. Huijsmans, the JOREK Team   +8 more
doaj   +1 more source

A Quantitative Model of Supply Chain Disruption Propagation Dynamics

Engineering Proceedings
Supply chain disruptions caused by natural disasters and human-made incidents have inflicted substantial losses on numerous companies. The management of supply chain risks, including disruption risk, has garnered significant attention from both academia ...
Shudong Liu, Shili Xiang, Lu Wang
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Interpretive JOREK simulation of thermal quench triggered by massive gas injection in EAST disruptions

Nuclear Fusion
JOREK 3D non-linear magnetohydrodynamic simulations with non-equilibrium impurity treatment of thermal quench (TQ) triggered by a massive neon gas in EAST L-mode disruptions are first presented.
W. Xia, D. Hu, L. Zeng, T. Tang, X. Zhu, T.H. Shi, D.L. Chen, H.K.R. Xu, K.N. Geng, J.J. Yang, S.B. Zhao, S.T. Mao, Y.M. Duan, H.D. Zhuang, Y. Huang, H.Q. Liu, T. Zhang, A. Ti, L.Q. Xu, L. Wang, Q. Zang, X. Gao, G.Q. Li, the JOREK Team   +23 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Simulation of DIII-D disruption with argon pellet injection and runaway electron beam

Nuclear Fusion
The next generation of large tokamaks, including ITER, will be equipped with a disruption mitigation system (DMS) that can be activated if a disruption is deemed to be imminent.
C. Zhao, C. Liu, S.C. Jardin, N.M. Ferraro, B.C. Lyons   +4 more
doaj   +1 more source

Disruption mitigation modeling for the SPARC tokamak

Physics of Plasmas
Two primary systems planned for disruption mitigation in the SPARC tokamak, massive gas injection (MGI), and the runaway electron mitigation coil (REMC), are modeled with the 3D MHD code NIMROD. MGI is modeled in four configurations, and each of the 6-valve and 4-valve configurations considered is predicted to produce a high radiation fraction (>
V. A. Izzo, B. Stein-Lubrano, A. Battey, R. Sweeney, C. Hansen, R. A. Tinguely   +5 more
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Impact of impurity seeding on shattered pellet injection mitigations on the Joint European Torus

Nuclear Fusion
Plasma disruptions present a significant challenge to the viability of fusion energy production in tokamak reactors. Among disruption mitigation techniques, shattered pellet injection (SPI) has emerged as a promising approach.
U. Sheikh, S. Jachmich, M. Kong, G. Bodner, N. Eidietis, O. Ficker, M. Lehnen, C. Reux, B. Stein-Lubrano, J. Svoboda, JET Contributors, the EUROfusion Tokamak Exploitation Team   +11 more
doaj   +1 more source