Results 31 to 40 of about 32,803 (265)

Determining Parental Factors for Clinical Trial Attrition in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background/Objectives Despite high enrollment rates on Children's Oncology Group (COG) protocols, attrition after initial consent is challenging, introducing bias and prolonging trial completion. While adult oncology literature has identified predictors of withdrawal, little is known about caregiver decision‐making for child participation in ...
Kimberly L. Stathas, Jakob Q. Weiss, Kellee N. Parker, Cathy Lee‐Miller   +3 more
wiley   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

“Show this thread”: policing, disruption and mobilisation through Twitter. An analysis of UK law enforcement tweeting practices during the Covid-19 pandemic

Crime Science, 2020
Crisis and disruption are often unpredictable and can create opportunities for crime. During such times, policing may also need to meet additional challenges to handle the disruption.
Manja Nikolovska, Shane D. Johnson, Paul Ekblom   +2 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Interpretative 3D MHD modelling of deuterium SPI into a JET H-mode plasma

Nuclear Fusion
The pre-thermal quench (pre-TQ) dynamics of a pure deuterium ( $\mathrm{D}_2$ ) shattered pellet injection (SPI) into a $3\,\mathrm{MA}$ / $7\,\mathrm{MJ}$ JET H-mode plasma is studied via 3D non-linear MHD modelling with the JOREK code.
M. Kong, E. Nardon, M. Hoelzl, D. Bonfiglio, D. Hu, S.-J. Lee, R. Samulyak, U. Sheikh, S. Silburn, F.J. Artola, A. Boboc, G. Bodner, P. Carvalho, E. Delabie, J.M. Fontdecaba, S.N. Gerasimov, T.C. Hender, S. Jachmich, D. Kos, K.D. Lawson, S. Pamela, C. Sommariva, Z̆. S̆tancar, B. Stein-Lubrano, H.J. Sun, R. Sweeney, G. Szepesi, the JOREK Team, JET Contributors   +28 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Multi-device analysis of energy loss duration and pellet penetration with implications for shattered pellet injection in ITER

Nuclear Fusion
A robust disruption mitigation system (DMS) requires accurate characterization of key disruption timescales, one of the most notable being the thermal quench (TQ).
G. Bodner, N. Eidietis, Z. Chen, P. Heinrich, J. Herfindal, S. Jachmich, G. Papp, J. Kim, M. Lehnen, U. Sheikh, I. Coffey, O. Ficker, S. Gerasimov, V. Kachkanov, C. Reux, S. Silburn, H. Sun, the ASDEX Upgrade Team, JET Contributors, the EUROfusion Tokamak Exploitation Team   +19 more
doaj   +1 more source

Supply chain disruption propagation: A study of South African fast-moving consumer goods food and beverage manufacturers

Acta Commercii, 2022
Orientation: Supply chain disruptions have been the subject of substantial theoretical exploration, resulting from the organisational need to enable understanding and appropriate responses to increasingly frequent and severe disruptive events.
Tristan Ermes, Neil Henderson, Zuni Staude, Wesley Niemann   +3 more
doaj   +1 more source

Identifying Risks and Mitigating Disruptions in the Automotive Supply Chain [PDF]

Interfaces, 2015
Firms are exposed to a variety of low-probability, high-impact risks that can disrupt their operations and supply chains. These risks are difficult to predict and quantify; therefore, they are difficult to manage. As a result, managers may suboptimally deploy countermeasures, leaving their firms exposed to some risks, while wasting resources to ...
David Simchi-Levi, William Schmidt, Yehua Wei, Peter Yun Zhang, Keith Combs, Yao Ge, Oleg Gusikhin, Michael Sanders, Don Zhang   +8 more
openaire   +3 more sources

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source