Results 81 to 90 of about 147,390 (303)

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Working as one: a road map to disaster resilience for Australia [PDF]

, 2014
This report offers a roadmap for enhancing Australia’s disaster resilience, building on the 2011 National Strategy for Disaster Resilience. It includes a snapshot of relevant issues and current resilience efforts in Australia, outlining key challenges ...
Anthony Bergin, Daniel Nichola, Paul Barnes   +2 more
core   +1 more source

Non-linear Simulations of MHD Instabilities in Tokamaks Including Eddy Current Effects and Perspectives for the Extension to Halo Currents

, 2014
The dynamics of large scale plasma instabilities can strongly be influenced by the mutual interaction with currents flowing in conducting vessel structures.
Aleynikova, K., Atanasiu, C., Chapman, I., Fil, A., Hoelzl, M., Huijsmans, G. T. A., Lackner, K., Liu, F., McAdams, R., Merkel, P., Nardon, E., Strumberger, E.   +11 more
core   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Simulations of stand-off runaway electron beam termination by tungsten particulates for tokamak disruption mitigation

Nuclear Fusion
Stand-off runaway electron termination by injected tungsten particulates offers a plausible option in the toolbox of disruption mitigation. Tungsten is an attractive material choice for this application due to large electron stopping power and high ...
Michael A. Lively, Danny Perez, Blas P. Uberuaga, Yanzeng Zhang, Xian-Zhu Tang   +4 more
doaj   +1 more source

Evaluating the Energy Security Implications of a Carbon-Constrained U.S. Economy [PDF]

, 2009
Examines how factors linked to U.S. energy security would be affected in eight scenarios in which carbon emissions are limited to a certain level.
Britt Childs Staley, Jenna Goodward, Kathryn Zyla, Sarah Ladislaw   +3 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Generic Continuity of Operations/Continuity of Government Plan for State-Level Transportation Agencies, Research Report 11-01 [PDF]

, 2011
The Homeland Security Presidential Directive 20 (HSPD-20) requires all local, state, tribal and territorial government agencies, and private sector owners of critical infrastructure and key resources (CI/KR) to create a Continuity of Operations ...
Edwards, Frances L., Goodrich, Daniel C., Medigovich, William M.   +2 more
core   +1 more source

Alarm-Based Prescriptive Process Monitoring

, 2018
Predictive process monitoring is concerned with the analysis of events produced during the execution of a process in order to predict the future state of ongoing cases thereof. Existing techniques in this field are able to predict, at each step of a case,
A Dachraoui, A Metzger, A Metzger, C Gröger, FM Maggi, J Platt, M Dees, M Fernández-Delgado, M Leoni de, R Conforti, R Tavenard, Z Xing   +11 more
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source