Results 11 to 20 of about 138,109 (218)

Establishment of a developmental toxicity assay based on human iPSC reporter to detect FGF signal disruption

iScience, 2022
Summary: The number of man-made chemicals has increased exponentially recently, and exposure to some of them can induce fetal malformations. Because complex and precisely programmed signaling pathways play important roles in developmental processes ...
Seiya Kanno, Yusuke Okubo, Tatsuto Kageyama, Lei Yan, Satoshi Kitajima, Junji Fukuda   +5 more
doaj   +1 more source

The evolutionary consequences of disrupted male mating signals: an agent-based modelling exploration of endocrine disrupting chemicals in the guppy. [PDF]

PLoS ONE, 2014
Females may select a mate based on signalling traits that are believed to accurately correlate with heritable aspects of male quality. Anthropogenic actions, in particular chemicals released into the environment, are now disrupting the accuracy of mating
Alistair McNair Senior, Shinichi Nakagawa, Volker Grimm   +2 more
doaj   +1 more source

Design of Real-Time Data Acquisition System for Tokamak Disruption Prediction

南方能源建设
[Introduction] Plasma disruption poses a significant threat to the tokamak nuclear device during its running and can cause damage to the device. Such damage can be reduced by adopting the disruption mitigation system, which has an action time highly ...
Peilong ZHANG, Weijie YE, Wei ZHENG, Yonghua DING, Liye WANG, Yulin YANG   +5 more
doaj   +1 more source

Disruption of Cerebellar Prediction in Verbal Working Memory

Frontiers in Human Neuroscience, 2019
Mounting evidence suggests that the right cerebellum contributes to verbal working memory, but the functional role of this contribution remains unclear. In an established theory of motor control, the cerebellum is thought to predict sensory consequences ...
Yi-Shin Sheu, Yu Liang, John E. Desmond
doaj   +1 more source

Adaptive anomaly detection disruption prediction starting from first discharge on tokamak

Nuclear Fusion
Plasma disruption presents a significant challenge in tokamak fusion, especially in large-size devices like ITER, where it causes severe damage. While current data-driven machine learning methods perform well in disruption prediction, they require ...
X.K. Ai, W. Zheng, M. Zhang, Y.H. Ding, D.L. Chen, Z.Y. Chen, B.H. Guo, C.S. Shen, N.C. Wang, Z.J. Yang, Z.P. Chen, Y. Pan, B. Shen, B.J. Xiao, J-TEXT team   +14 more
doaj   +1 more source

Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. [PDF]

PLoS Computational Biology, 2011
The ability of neurons to differentially respond to specific temporal and spatial input patterns underlies information storage in neural circuits. One means of achieving spatial specificity is to restrict signaling molecules to particular subcellular ...
Myungsook Kim, Alan Jung Park, Robbert Havekes, Andrew Chay, Leonardo Antonio Guercio, Rodrigo Freire Oliveira, Rodrigo Freire Oliveira, Ted Abel, Kim T Blackwell   +8 more
doaj   +1 more source

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Consensus Standards and Recommendations for Developmental and Cognitive Surveillance, Screening, and Evaluation in Sickle Cell Disease: Executive Summary From the National Alliance of Sickle Cell Centers Neurocognitive Workgroup

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurodevelopmental and neurocognitive difficulties are prevalent among individuals with sickle cell disease and warrant prompt identification and support. This Special Report provides an executive summary of standards and recommendations for surveillance, screening, and evaluation for development and cognition across the lifespan developed by ...
Alyssa M. Schlenz, Donna Murdaugh, Andrew M. Heitzer, Jennifer N. Longoria, Wendy Santos‐Modesitt, Arianna Martin, Judy Cavazos, Jeff Schatz, Catherine R. Hoyt, Alison King, Eboni I. Lance, Steven Hardy, Marsha Treadwell   +12 more
wiley   +1 more source

Balancing physics priors and data for disruption prediction in future tokamaks

Nuclear Fusion
Disruption remains a major barrier to the safe, sustained operation of tokamaks. Although current understanding of disruption physics is broadly valid across existing tokamaks, it cannot provide accurate disruption prediction rules.
Fengming Xue, Wei Zheng, Chengshuo Shen, Runyu Luo, Bihao Guo, Dalong Chen, Zhongyong Chen, Zhipeng Chen, Zhoujun Yang, Yonghua Ding, Yuan Pan, J-TEXT Team   +11 more
doaj   +1 more source

Tungsten melting and erosion under plasma heat load in tokamak discharges with disruptions

Nuclear Materials and Energy, 2017
Full tungsten poloidal and mushroom limiters were tested in series of experiments with disruptions in the T-10 tokamak. Significant melting, formation of small craters and erosion of the tungsten limiter have been observed after ∼400 discharges with ...
V.P. Budaev, Yu.V. Martynenko, S.A. Grashin, R.N. Giniyatulin, I.I. Arkhipov, A.V. Karpov, P.V. Savrukhin, E.A. Shestakov, R.Yu. Solomatin, L.B. Begrambekov, N.E. Belova, S.D. Fedorovich, L.N. Khimchenko, V.M. Safronov   +13 more
doaj   +1 more source